FOLLICLE-STIMULATING HORMONE STIMULATES GLUTATHIONE SYNTHESIS IN PRIMARY RAT GRANULOSA CELLS BY UPREGULATING GLUTAMATE CYSTEINE LIGASE: ROLE OF CYCLIC AMP

2007 ◽  
Vol 77 (Suppl_1) ◽  
pp. 86-86
Author(s):  
Yvonne Hoang ◽  
Ulrike Luderer
Keyword(s):  
Cyclic Amp ◽  
Granulosa Cells ◽  
Follicle Stimulating Hormone ◽  
Glutamate Cysteine Ligase ◽  
Glutathione Synthesis ◽  
Stimulating Hormone

MATURATIONAL CHANGES IN SHEEP OVARIAN FOLLICLES: GONADOTROPHIC STIMULATION OF CYCLIC AMP PRODUCTION BY ISOLATED THECA AND GRANULOSA CELLS

1978 ◽  
Vol 89 (1) ◽  
pp. 166-172 ◽  
Author(s):  
T. J. Weiss ◽  
D. T. Armstrong ◽  
J. E. A. McIntosh ◽  
R. F. Seamark
Keyword(s):  
Cyclic Amp ◽  
Granulosa Cells ◽  
Follicle Stimulating Hormone ◽  
Adenosine Monophosphate ◽  
Ovarian Follicles ◽  
Chorionic Gonadotrophin ◽  
Human Chorionic Gonadotrophin ◽  
Camp Production ◽  
Stimulation Of ◽  
Stimulating Hormone

ABSTRACT Theca and granulosa tissues isolated from sheep ovarian follicles of different sizes were incubated in the presence of human chorionic gonadotrophin (HCG; 5 IU/ml) or follicle stimulating hormone (FSH; 5 μg NIH-FSH-S11/ml) for 40 min. Changes in the total amounts of cyclic 3′,5′-adenosine monophosphate (cAMP) were used as an index of the responsiveness of these preparations to the hormones. Thecal tissue of both large (4–6 mm in diameter) and small (1–3 mm) follicles responded similarly to gonadotrophins. Granulosa cells from small follicles failed to respond to stimulation by HCG. FSH, however, consistently increased cAMP production in comparison with controls or cells treated with HCG. Granulosa cells of large follicles responded to both HCG and FSH.

The Role of Estradiol as a Biological Amplifier of the Actions of Follicle-Stimulating Hormone: In Vitro Studies in Swine Granulosa Cells*

Endocrinology ◽  
1982 ◽  
Vol 111 (1) ◽  
pp. 144-151 ◽  
Author(s):  
JOHANNES D. VELDHUIS ◽  
PATRICIA A. KLASE ◽  
JEROME F. STRAUSS ◽  
JAMES M. HAMMOND
Keyword(s):  
Granulosa Cells ◽  
Follicle Stimulating Hormone ◽  
In Vitro Studies ◽  
Stimulating Hormone

Granulosa Cells as Hormone Targets: The Role of Biologically Active Follicle-Stimulating Hormone in Reproduction

1989 ◽  
pp. 209-277 ◽  
Author(s):  
AARON J.W. HSUEH ◽  
THOMAS A. BICSAK ◽  
XIAO-CHI JIA ◽  
KRISTINE D. DAHL ◽  
BART C.J.M. FAUSER ◽  
...  
Keyword(s):  
Granulosa Cells ◽  
Follicle Stimulating Hormone ◽  
Biologically Active ◽  
Stimulating Hormone

EFFECTS OF FOLLICLE-STIMULATING HORMONE AND LUTEINIZING HORMONE ON OVARIAN CYCLIC AMP AND PROSTAGLANDIN E IN VIVO IN RATS TREATED WITH INDOMETHACIN

1976 ◽  
Vol 70 (2) ◽  
pp. 285-291 ◽  
Author(s):  
G. L. RIGLER ◽  
G. T. PEAKE ◽  
A. RATNER
Keyword(s):  
Luteinizing Hormone ◽  
Cyclic Amp ◽  
Intravenous Injection ◽  
Follicle Stimulating Hormone ◽  
Prior Treatment ◽  
Prostaglandin E ◽  
Cyclic Amp Accumulation ◽  
Stimulating Hormone

SUMMARY The role of prostaglandins in both FSH- and LH-mediated increases in ovarian cyclic AMP was examined in rats in vivo. Dose-related increases in ovarian cyclic AMP levels were observed 10 min after intravenous injection of FSH or LH. No changes in ovarian prostaglandin E (PGE) content were detected after injection of either gonadotrophin at doses which substantially enhanced cyclic AMP accumulation. Prior treatment of rats with indomethacin produced a greater than 50% decrease in ovarian PGE levels, but did not prevent the FSH- or LH-induced rise in ovarian cyclic AMP concentration. These in vivo experiments do not support the concept that PGE plays a role as an obligatory mediator for the gonadotrophin-induced rise in ovarian cyclic AMP levels.

Peripheral and local regulators of folliculogenesis

1994 ◽  
Vol 6 (2) ◽  
pp. 127 ◽  
Author(s):  
JK Findlay
Keyword(s):  
Luteinizing Hormone ◽  
Granulosa Cells ◽  
Follicle Stimulating Hormone ◽  
Follicular Atresia ◽  
Local Regulation ◽  
Premature Luteinization ◽  
Stimulating Hormone

The role of the gonadotrophins follicle-stimulating hormone (FSH) and luteinizing hormone and the putative local regulators, activin and follistatin, in the control of folliculogenesis is reviewed. An account of early work on the development and application of assays for FSH and inhibin is given, together with a summary of the data on the ovarian responsiveness to gonadotrophin and follicular atresia. Models for studying local regulation of granulosa cells in vitro are described and the data from these experiments reviewed. It is concluded that activin has a role in the development and maintenance of healthy oestrogenic follicles, preventing premature luteinization, whereas follistatin opposes these effects of activin and promotes luteinization or atresia.

Sign in / Sign up

Export Citation Format

Share Document