A score test for the linkage analysis of qualitative and quantitative traits based on identity by descent data from sib-pairs

Biostatistics ◽  
2000 ◽  
Vol 1 (1) ◽  
pp. 1-26 ◽  
Author(s):  
Sandrine Dudoit ◽  
Terence P. Speed
Keyword(s):  
Linkage Analysis ◽  
Quantitative Traits ◽  
Score Test ◽  
Identity By Descent ◽  
Descent Data ◽  
Qualitative And Quantitative ◽  
Sib Pairs

Linkage analysis of 2q14-q23 and 5q32 with blood pressure quantitative traits in Chinese sib pairs

2003 ◽  
Vol 21 (2) ◽  
pp. 305-310 ◽  
Author(s):  
Dongliang Ge ◽  
Wenjie Yang ◽  
Jianfeng Huang ◽  
Cailiang Yao ◽  
Xisheng Xu ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Linkage Analysis ◽  
Quantitative Traits ◽  
Sib Pairs

scholarly journals A score test for linkage using identity by descent data from sibships

1999 ◽  
Vol 27 (3) ◽  
pp. 943-986 ◽  
Author(s):  
Sandrine Dudoit ◽  
Terence P. Speed
Keyword(s):  
Score Test ◽  
Identity By Descent ◽  
Descent Data

scholarly journals Statistical methods for linkage analysis of complex traits from high-resolution maps of identity by descent.

Genetics ◽  
1995 ◽  
Vol 140 (2) ◽  
pp. 843-856
Author(s):  
J Dupuis ◽  
P O Brown ◽  
D Siegmund
Keyword(s):  
Linkage Analysis ◽  
Statistical Methods ◽  
Complex Traits ◽  
Gene Interaction ◽  
Polymorphic Markers ◽  
Identity By Descent ◽  
Descent Data ◽  
Multilocus Model ◽  
Multiplicative Models ◽  
Dense Set

Abstract A multilocus model for complex traits is described that generalizes the additive and multiplicative models and hence allows simultaneously for both heterogeneity and gene interaction (epistasis). Statistical methods of linkage analysis are discussed under the assumption that identity by descent data from a dense set of polymorphic markers are available. Three methods, single locus search, simultaneous search and conditional search, are described and compared.

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