Abstract
Background: Cardiac involvement in EGPA indicates poor prognosis and high mortality, while few data about cardiac involvement of EGPA in Chinese population are available. We conducted this study to figure out the clinical characteristics and overall outcome of EGPA patients with cardiac involvement in Chinese population.Methods: We retrospectively collected the clinical data of 83 patients diagnosed with EGPA and analyzed the differences between patients with and without cardiac involvement.Results: The prevalence of cardiac involvement of EGPA in this cohort was 27.7%. Compared with those who without cardiac involvement, EGPA patients with cardiac involvement tended to have younger onset age (mean ± SD, 38.4 ± 10.5 vs. 42.1 ± 15.9 years, p=0.039), higher eosinophil count [median (IQR), 5810 (4020-11090) vs. 2880 (1530-6570) n/μL , p=0.004)], higher disease activity [median (IQR), 20 (16-28) vs. 15 (12-18), p=0.001)] and poorer prognosis (FFS≥1, 100% vs. 38.3%, p=0.001). The most common cardiac manifestation was chest pain (56.5%), and 43.5% of patients were asymptomatic but cardiac abnormalities could be detected by cardiac examinations. With appropriate treatment, the overall outcome of EGPA patients with cardiac involvement in our cohort turned out to be good, with 3 ( 13% ) patients died at acute phase and no patient died during follow-up.Conclusions: Cardiac involvement was common in EGPA and was associated with younger onset age, higher eosinophil count, higher disease activity and poorer prognosis. Comprehensive cardiac examinations and appropriate treatment are essential to improve the prognosis of cardiac involvement.
MDM2 SNP309 G allele increases risk but the T allele is associated with earlier onset age of sporadic breast cancers in the Chinese population