scholarly journals Age-Dependent Long-Term Potentiation Deficits in the Prefrontal Cortex of theFmr1Knockout Mouse Model of Fragile X Syndrome

2015 ◽  
Vol 26 (5) ◽  
pp. 2084-2092 ◽  
Author(s):  
Henry G. S. Martin ◽  
Olivier Lassalle ◽  
Jonathan T. Brown ◽  
Olivier J. Manzoni
Keyword(s):  
Prefrontal Cortex ◽  
Mouse Model ◽  
Fragile X Syndrome ◽  
Fragile X ◽  
Long Term Potentiation ◽  
Term Potentiation ◽  
Age Dependent

scholarly journals Altered A-type potassium channel function impairs dendritic spike initiation and temporammonic long-term potentiation in Fragile X syndrome

2021 ◽  
Author(s):  
Gregory J. Ordemann ◽  
Christopher J. Apgar ◽  
Raymond A. Chitwood ◽  
Darrin H Brager
Keyword(s):  
Fragile X Syndrome ◽  
Fragile X ◽  
Long Term Potentiation ◽  
Autism Spectrum ◽  
K Channels ◽  
Spike Threshold ◽  
Type K ◽  
Term Potentiation ◽  
Dendritic Spike

Fragile X syndrome (FXS) is the leading monogenetic cause of cognitive impairment and autism spectrum disorder. Area CA1 of the hippocampus receives current information about the external world from the entorhinal cortex via the temporoammonic (TA) pathway. Given its role in learning and memory, it is surprising that little is known about TA long-term potentiation (TA-LTP) in FXS. We found that TA-LTP was impaired in fmr1 KO mice. Furthermore, dendritic Ca2+ influx was smaller and dendritic spike threshold was depolarized in fmr1 KO mice. Dendritic spike threshold and TA-LTP were restored by block of A-type K+ channels. The impairment of TA-LTP coupled with enhanced Schaffer collateral LTP may contribute to spatial memory alterations in FXS. Furthermore, as both of these LTP phenotypes are attributed to changes in A-type K+ channels in FXS, our findings provide a potential therapeutic target to treat cognitive impairments in FXS.

Seizure induced synthesis of fibronectin is rapid and age dependent: implications for long-term potentiation and sprouting

1998 ◽  
Vol 812 (1-2) ◽  
pp. 209-215 ◽  
Author(s):  
Keith B Hoffman ◽  
Jason K Pinkstaff ◽  
Christine M Gall ◽  
Gary Lynch
Keyword(s):  
Long Term Potentiation ◽  
Term Potentiation ◽  
Age Dependent

Long-term potentiation in the hippocampus of fragile X knockout mice

1996 ◽  
Vol 64 (2) ◽  
pp. 246-251 ◽  
Author(s):  
Jean-Marie Godfraind ◽  
Edwin Reyniers ◽  
Kristel De Boulle ◽  
Rudi D'Hooge ◽  
Peter P. De Deyn ◽  
...  
Keyword(s):  
Knockout Mice ◽  
Fragile X ◽  
Long Term Potentiation ◽  
Term Potentiation
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