Risk for Tympanic Membrane Perforation After Quinolone Ear Drops for Acute Otitis Externa

2019 ◽  
Author(s):  
Xi Wang ◽  
Almut G Winterstein ◽  
Adel Alrwisan ◽  
Patrick J Antonelli
Keyword(s):  
Tympanic Membrane ◽  
Otitis Externa ◽  
Tympanic Membrane Perforation ◽  
Membrane Perforation ◽  
Ear Drops

Common drugs used in ENT

2009 ◽  
pp. 347-350
Author(s):  
Rogan Corbridge ◽  
Nicholas Steventon
Keyword(s):  
Inner Ear ◽  
Tympanic Membrane ◽  
Middle Ear ◽  
Otitis Externa ◽  
Round Window ◽  
Acid Reflux ◽  
Tympanic Membrane Perforation ◽  
Active Infection ◽  
Middle Ear Mucosa ◽  
Membrane Perforation

Drugs used in the ear 348 Drugs used in the nose 349 Drugs used in the treatment of acid reflux 350 This group of drugs is widely used for the treatment of otitis externa. Otitis externa 2 drops tds for 10 days Presence of grommet or tympanic membrane perforation due to aminoglycoside ototoxicity in the inner ear. Risk thought to be low in the presence of active infection where the middle-ear mucosa is swollen and the antibiotic is unlikely to reach the inner ear via the round window...

Ototoxicity after use of neomycin eardrops is unrelated to A1555G point mutation in mitochondrial DNA

2004 ◽  
Vol 118 (7) ◽  
pp. 546-550 ◽  
Author(s):  
Tatsuya Yamasoba ◽  
Katsunori Tsukuda
Keyword(s):  
Mitochondrial Dna ◽  
Tympanic Membrane ◽  
Point Mutation ◽  
Middle Ear ◽  
Dna Analysis ◽  
Tympanic Membrane Perforation ◽  
Mitochondrial Dna Analysis ◽  
Membrane Perforation ◽  
Inner Ear Damage ◽  
Ear Drops

Ear drops containing neomycin only rarely cause ototoxicity. The authors report on three patients with a tympanic membrane perforation who developed severe ototoxicity after use of eardrops containing 0.35 per cent neomycin. Mitochondrial DNA analysis revealed that there was no A1555G point mutation in these patients. This finding indicates that application of low concentration neomycin to the middle ear can cause severe inner ear damage even in humans who are not hyper-susceptible to aminoglycosides.

Fungal Otitis Externa as a Cause of Tympanic Membrane Perforation: A case series

2014 ◽  
Vol 93 (8) ◽  
pp. 332-336 ◽  
Author(s):  
James Eingun Song ◽  
Thomas J. Haberkamp ◽  
Riddhi Patel ◽  
Miriam I. Redleaf
Keyword(s):  
Tympanic Membrane ◽  
Otitis Externa ◽  
Case Series ◽  
Tympanic Membrane Perforation ◽  
Membrane Perforation

scholarly journals Effectiveness of oral itraconazole in the management of otomycosis with tympanic membrane perforation

2017 ◽  
Vol 5 (4) ◽  
pp. 1373 ◽  
Author(s):  
Aju Ravindran ◽  
Sagesh M.
Keyword(s):  
Tympanic Membrane ◽  
Treatment Response ◽  
Difficult Problem ◽  
Tympanic Membrane Perforation ◽  
Prolonged Treatment ◽  
Membrane Perforation ◽  
Oral Itraconazole ◽  
Methods Of Treatment ◽  
Perforated Tympanic Membrane ◽  
Ear Drops

Background: Otomycosis can be a difficult problem to treat in a patient who already has a perforation of the tympanic membrane. This study highlights the effectiveness of oral Itraconazole in treating such cases.Methods: Thirty-four patients with otomycosis and a perforated tympanic membrane were included in the study and were treated with oral itraconazole and antibiotic ear drops. They were followed up for six weeks to look for treatment response and any recurrence.Results: Of the 34 patients in the study, 25 patients were fully cured with one week of oral Itraconazole therapy. Six out of the remaining 9 patients were cured of the disease with two weeks’ therapy. Three patients needed prolonged treatment and one patient had a recurrence at six weeks.Conclusions: Oral itraconazole therapy is an effective alternative to the traditional methods of treatment for otomycosis with tympanic membrane perforation.

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