scholarly journals Effectiveness of oral itraconazole in the management of otomycosis with tympanic membrane perforation

2017 ◽  
Vol 5 (4) ◽  
pp. 1373 ◽  
Author(s):  
Aju Ravindran ◽  
Sagesh M.
Keyword(s):  
Tympanic Membrane ◽  
Treatment Response ◽  
Difficult Problem ◽  
Tympanic Membrane Perforation ◽  
Prolonged Treatment ◽  
Membrane Perforation ◽  
Oral Itraconazole ◽  
Methods Of Treatment ◽  
Perforated Tympanic Membrane ◽  
Ear Drops

Background: Otomycosis can be a difficult problem to treat in a patient who already has a perforation of the tympanic membrane. This study highlights the effectiveness of oral Itraconazole in treating such cases.Methods: Thirty-four patients with otomycosis and a perforated tympanic membrane were included in the study and were treated with oral itraconazole and antibiotic ear drops. They were followed up for six weeks to look for treatment response and any recurrence.Results: Of the 34 patients in the study, 25 patients were fully cured with one week of oral Itraconazole therapy. Six out of the remaining 9 patients were cured of the disease with two weeks’ therapy. Three patients needed prolonged treatment and one patient had a recurrence at six weeks.Conclusions: Oral itraconazole therapy is an effective alternative to the traditional methods of treatment for otomycosis with tympanic membrane perforation.

Ototoxicity after use of neomycin eardrops is unrelated to A1555G point mutation in mitochondrial DNA

2004 ◽  
Vol 118 (7) ◽  
pp. 546-550 ◽  
Author(s):  
Tatsuya Yamasoba ◽  
Katsunori Tsukuda
Keyword(s):  
Mitochondrial Dna ◽  
Tympanic Membrane ◽  
Point Mutation ◽  
Middle Ear ◽  
Dna Analysis ◽  
Tympanic Membrane Perforation ◽  
Mitochondrial Dna Analysis ◽  
Membrane Perforation ◽  
Inner Ear Damage ◽  
Ear Drops

Ear drops containing neomycin only rarely cause ototoxicity. The authors report on three patients with a tympanic membrane perforation who developed severe ototoxicity after use of eardrops containing 0.35 per cent neomycin. Mitochondrial DNA analysis revealed that there was no A1555G point mutation in these patients. This finding indicates that application of low concentration neomycin to the middle ear can cause severe inner ear damage even in humans who are not hyper-susceptible to aminoglycosides.

scholarly journals A rare cause of acute tympanic membrane perforation: a case report

2018 ◽  
Vol 5 (1) ◽  
pp. 181
Author(s):  
C. J. Timna ◽  
Abhijit Kumar
Keyword(s):  
Case Report ◽  
Tympanic Membrane ◽  
Sudden Onset ◽  
Tympanic Membrane Perforation ◽  
Complete Healing ◽  
Accident And Emergency ◽  
Membrane Perforation ◽  
Accident And Emergency Department ◽  
Perforated Tympanic Membrane

<p class="abstract">This is a case report of 57yrs old gentleman who presented to accident and emergency department with complaints of sudden onset of left earache, tinnitus, feeling of fullness in the ear which he claimed to start following an episode of sudden sneezing, while he was trying to blow his nose by pinching it with 2 fingers. The tympanic membrane was ruptured. He was managed conservatively with analgesics. Spontaneous and complete healing of the perforated tympanic membrane occured within one month of follow up. It was shown that an episode of sneezing with nose closed can build up such a high pressure in the middle ear which can perforate a tympanic membrane.</p>

scholarly journals Histological evaluation of effect of PDGF-rich plasma on the tympanic membrane

2020 ◽  
pp. 56-61
Author(s):  
A. I. Kriukov ◽  
A. V. Gurov ◽  
A. A. Bakhtin ◽  
Z. V. Murzakhanova
Keyword(s):  
Growth Factors ◽  
Connective Tissue ◽  
Tympanic Membrane ◽  
Tympanic Membrane Perforation ◽  
Main Group ◽  
Histological Evaluation ◽  
Control Group ◽  
Membrane Perforation ◽  
Perforated Tympanic Membrane ◽  
Tympanic Membranes

Introduction. Тo study the microscopic picture of the tissues of the perforated tympanic membrane after the introduction of blood plasma enriched with platelet growth factors into the perforated area of the tympanic membrane in the experiment.Materials and methods. 36 rats (72 tympanic membranes) were examined. The animals were divided into 2 groups, the main and the control. The tympanic membrane was perforated in rats of both groups using sterile play. Animals of the main group were injected with a single application of autoplasm of blood enriched with platelet growth factors into the area of perforation of the tympanic membrane. The animals of the control group underwent only dynamic observation. The rats were withdrawn from the experiment in batches of 6 individuals on day 5, 10, 15 after the tympanic membrane perforation, then a histological assessment of the tissue regeneration of the tympanic membranes was performed. Results. In animals of the main group on the 5th day after perforation of the tympanic membrane, edema and disorganization of connective tissue were significantly less frequently recorded than in animals of the control group (p ≤ 0.05). Fibroblastic infiltration of tympanic membrane tissues was significantly more often observed in rats of the main group compared with rats in the control group (p ≤ 0.05). In rats of the main group on the 10th day after perforation of the tympanic membrane, edema and disorganization of the connective tissue of the tympanic membranes were noted significantly less frequently than in rats of the control group (p ≤ 0.05). Signs of fibroblastic infiltration and neoangiogenesis at the same time in animals of the main group were revealed significantly more often, in contrast to rats in the control group (p ≤ 0.05). In animals of the main group, on the 15th day after perforation of the tympanic membrane, fibroblastic infiltration and neoangiogenesis were revealed in all cases of observation, which significantly exceeded the corresponding indicators in the control group, and leukocyte infiltration in rats of the main group, in contrast to the previous stages of the study, was noted significantly less frequently. than in rats of the control group (p ≤ 0.05).Conclusion. Earlier and complete regeneration of damaged tissues of the tympanic membrane under conditions of its traumatic perforation was noted in rats of the main group under the influence of PCOTFR. In rats of the main group, more organized collagen fibers, the presence of basophilic leukocytes, signs of neoangiogenesis, and extensive fields of fibroblasts were visualized.

Potential ototoxicity from triamcinolone, neomycin, gramicidin and nystatin (Tri-Adcortyl™) cream

2005 ◽  
Vol 119 (1) ◽  
pp. 48-50 ◽  
Author(s):  
S P Thomas ◽  
J R Buckland ◽  
S R Rhys-Williams
Keyword(s):  
Hearing Loss ◽  
Sensorineural Hearing Loss ◽  
Tympanic Membrane ◽  
Tympanic Membrane Perforation ◽  
Sensorineural Hearing ◽  
Ear Canal ◽  
Membrane Perforation ◽  
Perforated Tympanic Membrane

Although rare, ototoxicity from the use of aminoglycoside drops is well recognized. Ototoxicity has not been described with the use of combination aminoglycoside-steroid-antifungal creams or ointments. We present the case of a 60-year-old man with a perforated tympanic membrane who suffered a total hearing loss after the instillation of cream containing triamcinolone, neomycin, gramicidin and nystatin (Tri-Adcortyl™ cream) into his ear canal. On balance, we believe that a number of potentially ototoxic constituents in this cream were responsible. Other possible causes of sensorineural hearing loss and the possible mechanisms of ototoxicity of this cream are discussed. The reasons why such creams may be particularly ototoxic, compared with drops, are also considered. The authors caution against the use of such creams or ointments in the ear if there is any suspicion of a tympanic membrane perforation.

Chronic otorrhoea, otalgia and hearing loss not responding to antibiotics and tympanoplasty surgery

2021 ◽  
Vol 14 (4) ◽  
pp. e240897
Author(s):  
Hannes Hermann Brandt ◽  
Frank Uwe Metternich ◽  
Raffaela Fürer
Keyword(s):  
Hearing Loss ◽  
Tympanic Membrane ◽  
Outpatient Clinic ◽  
Tympanic Membrane Perforation ◽  
Progressive Hearing Loss ◽  
Adequate Treatment ◽  
The Past ◽  
Membrane Perforation ◽  
Perforated Tympanic Membrane ◽  
Histological Specimen

Chronic otorrhoea from a tympanic membrane perforation is common. We present the case of a patient who had already received seemingly adequate treatment for his condition in the past. Yet, he presented to our outpatient clinic with worsening otalgia and otorrhoea, progressive hearing loss and a new tympanic membrane perforation. After a thorough otological evaluation, the patient’s medical history and the histological specimen from a previous operation were reviewed. The findings met the diagnostic criteria of eosinophilic otitis media. After treatment with topic triamcinolone through the perforated tympanic membrane, the patient’s otalgia subsided, hearing levels were improved and the size of the tympanic membrane perforation decreased.

Sign in / Sign up

Export Citation Format

Share Document