Detection of Patients with Low Serum Cholinesterase Activity: Inadequacy of "Acholest" Method

1972 ◽  
Vol 18 (6) ◽  
pp. 565-566 ◽  
Author(s):  
Albert A Dietz ◽  
Herbert Rubinstein ◽  
Tina Lubrano
Keyword(s):  
High Risk ◽  
Screening Test ◽  
Cholinesterase Activity ◽  
Serum Cholinesterase ◽  
Preoperative Screening ◽  
Test Paper ◽  
Prolonged Apnea ◽  
Serum Cholinesterase Activity ◽  
Paper Method ◽  
Low Serum

Abstract The "Acholest" test-paper method for estimating serum cholinesterase activity has been suggested as a preoperative screening test for patients potentially liable to prolonged apnea after use of succinylcholine. The method was tested on selected sera from normal persons and from patients with various hereditary variants of serum cholinesterase and results were compared to those obtained with a standard quantitative assay. The Acholest method failed to detect 12 of 20 cases at high risk of prolonged apnea after succinylcholine. It cannot therefore be considered as a suitable screening procedure.

A LOW SERUM CHOLINESTERASE ACTIVITY INDICATES A HIGHER MORTALITY IN CRITICALLY ILL PEDIATRIC PATIENTS.

2006 ◽  
Vol 34 ◽  
pp. A129
Author(s):  
Christian Sitzwohl ◽  
Thomas Gamsjäger ◽  
Carmen Anderle ◽  
Christian Weinstabl ◽  
Stephan C Kettner
Keyword(s):  
Critically Ill ◽  
Pediatric Patients ◽  
Cholinesterase Activity ◽  
Serum Cholinesterase ◽  
Serum Cholinesterase Activity ◽  
Low Serum

Ethnic differences in the frequency of distribution of serum cholinesterase activity in the Iranian population

2004 ◽  
Vol 82 (5) ◽  
pp. 326-330 ◽  
Author(s):  
Nasser Vahdati-Mashhadian ◽  
Mohammad K Hassanzadeh ◽  
Javad Hosseini ◽  
Ali A Saffareshargh
Keyword(s):  
Ethnic Differences ◽  
High Frequency ◽  
Cholinesterase Activity ◽  
Muscle Relaxants ◽  
Iranian Population ◽  
Serum Cholinesterase ◽  
Prolonged Apnea ◽  
Serum Cholinesterase Activity ◽  
Cocaine Toxicity ◽  
Atypical Variant

One thousand Iranians belonging to 5 different Iranian ethnic groups were tested for butyrylcholinesterase (BChE) activity and phenotype. The phenotype was measured as percent inhibition in the presence of dibucaine. It was found that the Iranian population had an extraordinarily high frequency of the atypical variant of butyrylcholinesterase. 70% to 80% of Iranians carried the atypical mutation (Asp70Gly) on one allele. This contrasts with European and American populations where only 4% carry the atypical allele. The atypical variant of butyrylcholinesterase is known to be associated with prolonged apnea after administration of the muscle relaxants succinylcholine and mivacurium, and is also thought to be associated with abnormal sensitivity to cocaine toxicity. This study demonstrates that the ethnic background of a person has an important role in a person's response to drugs.Key words: butyrylcholinesterase, dibucaine number, heterozygous genes, different Iranian ethnics, metabolic polymorphism.

scholarly journals Genetic analysis of mutations in individuals with low serum cholinesterase activity.

1994 ◽  
Vol 38 (3) ◽  
pp. 201-208
Author(s):  
Masato Maekawa ◽  
Kayoko Sudo ◽  
Dilip Chandra Dey ◽  
Kazuo Kotani ◽  
Jinko Ishikawa ◽  
...  
Keyword(s):  
Genetic Analysis ◽  
Cholinesterase Activity ◽  
Serum Cholinesterase ◽  
Serum Cholinesterase Activity ◽  
Low Serum

A simple staining method to detect serum cholinesterase activity

1987 ◽  
Vol 164 (2) ◽  
pp. 241-242 ◽  
Author(s):  
Masato Maekawa ◽  
Kayoko Sudo ◽  
Takashi Kanno
Keyword(s):  
Cholinesterase Activity ◽  
Staining Method ◽  
Serum Cholinesterase ◽  
Serum Cholinesterase Activity

scholarly journals Effect of Serum Cholinesterase Activity on Muscle Relaxation by Succinylcholine in Rats

1984 ◽  
Vol 104 (4) ◽  
pp. 406-408
Author(s):  
KAZUNORI KITAMURA ◽  
KAZUNORI KATAYAMA ◽  
MASAWO KAKEMI ◽  
TAMOTSU KOIZUMI
Keyword(s):  
Cholinesterase Activity ◽  
Muscle Relaxation ◽  
Serum Cholinesterase ◽  
Serum Cholinesterase Activity
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