Determination of fluoxetine and norfluoxetine in plasma by gas chromatography with electron-capture detection.

1982 ◽  
Vol 28 (10) ◽  
pp. 2100-2102 ◽  
Author(s):  
J F Nash ◽  
R J Bopp ◽  
R H Carmichael ◽  
K Z Farid ◽  
L Lemberger
Keyword(s):  
Gas Chromatography ◽  
Human Plasma ◽  
Electron Capture ◽  
Relative Error ◽  
Chromatographic Method ◽  
Linear Range ◽  
Electron Capture Detector ◽  
Electron Capture Detection ◽  
Gas Chromatographic Method

Abstract This gas-chromatographic method for assay of fluoxetine and norfluoxetine in human plasma involves extraction of the drugs and use of a 63Ni electron-capture detector. The linear range of detection is 25 to 800 micrograms/L for each drug. Overall precision (CV) in the concentration range of 10 to 100 micrograms/L for both drugs was approximately 10%. Accuracy (relative error) in the same concentration range was approximately +10%. None of the commonly prescribed antidepressants or tranquilizers that we tested interfere with the assay.

Gas Chromatographic Determination of N-Butyl-N-ethyl-α,α,α-trifluoro-2,6-dinitro-p-toluidine and α,α,α-Trifluoro-2,6-dinitro-N,N-dipropyl-p-toluidine in Formulations

1971 ◽  
Vol 54 (3) ◽  
pp. 711-712
Author(s):  
Martha Fuzesi
Keyword(s):  
Gas Chromatography ◽  
Quantitative Determination ◽  
Electron Capture ◽  
Chromatographic Method ◽  
Chromatographic Determination ◽  
Electron Capture Detector ◽  
Reference Solution ◽  
Gas Chromatographic Method

Abstract A gas chromatographic method is described for the quantitative determination of N-butyl-N-ethyl-α,α,α-trifluoro-2,6-dinitro-p-tolindine and α,α,α-trifluoro-2,6-dinitro-N,N-dipropyI-p-toluidine herbicides in formulations. The sample is extracted with benzene, and equal amounts of sample and reference solution in the same concentration range are analyzed by gas chromatography, using an electron capture detector and an SE-30/Diatoport S column. The method has been applied successfully to laboratory-prepared and commercial samples.

Gas Chromatographie Determination of Subnanogram Amounts of the Juvenile Hormone Methyl (2E, 6E)-10,ll-epoxy-3,7,ll-tri- methyl-2,6-dodecadienoate (JH III) in Insect Material by Electron Capture Detection

1975 ◽  
Vol 30 (11-12) ◽  
pp. 726-729 ◽  
Author(s):  
L Van Broekhoven ◽  
A Van Der Kerk ◽  
-Van Hoof ◽  
C Salemink
Keyword(s):  
Juvenile Hormone ◽  
Electron Capture ◽  
Chromatographic Method ◽  
Electron Capture Detector ◽  
Electron Capture Detection ◽  
Juvenile Hormones ◽  
Gas Chromatographic Method ◽  
Work Up

Abstract Using an electron capture detector, a sensitive gas chromatographic method has been developed for the determination of the juvenile hormone methyl(2E, 6E)-10, 11-epoxy-3,7,11-trimethyl-2,6-dodecadienoate (JH III) in insect material. The sensitivity in electron capture detection of the bisheptafluorobutyrate was determined. The work-up procedure was checked by adding known amounts of JH III to insect material. The method seems equally applicable to all three juvenile hormones.

Electron Capture Gas Chromatographic Determination of Traces of Formaldehyde in Milk as the 2,4-Dinitrophenylhydrazone

1986 ◽  
Vol 69 (4) ◽  
pp. 655-657
Author(s):  
Katherine E Buckley ◽  
Lorne J Fisher ◽  
Vernon G MacKay
Keyword(s):  
Gas Chromatography ◽  
Electron Capture ◽  
Quantitative Method ◽  
Chromatographic Method ◽  
Packed Column ◽  
Chromatographic Determination ◽  
Electron Capture Detection ◽  
External Standard

Abstract A quantitative method is described for the determination of formaldehyde in milk by packed-column gas chromatography and electron capture detection. Aldehyde derivatization was carried out in situ with 2,4-dinitrophenyIhydrazine followed by extraction and analysis using an external standard. Average recoveries of 96.3 ± 1.6% were characteristic of the chromatographic method with an estimated detection limit of 0.026 mg/kg. The technique was applied to determination of formaldehyde in milk from cows consuming a formalin-treated feedstuff.

Analysis of Total Free and Glucose-Conjugated Pyrethroid Acid Metabolites in Tea Infusions as Hexafluoroisopropyl Esters by Gas Chromatography with Electron Capture Detection

1995 ◽  
Vol 78 (3) ◽  
pp. 846-855 ◽  
Author(s):  
Richard D Mortimer ◽  
Dorcas F Weber ◽  
Wing F Sun
Keyword(s):  
Mass Spectrometry ◽  
Gas Chromatography ◽  
Electron Capture ◽  
Chromatographic Method ◽  
Electron Capture Detection ◽  
Tea Leaves ◽  
Tea Infusions ◽  
Acid Metabolites ◽  
Pyrethroid Metabolites ◽  
Gas Chromatographic Method

Abstract A gas chromatographic method with electron capture detection (GC–ECD) has been developed to quantitate the sum of free acids of pyrethroid metabolites, their glucosides, and their other base-cleav-able conjugates that are extracted from tea leaves when a tea infusion is prepared. Four representative glucoside conjugates were synthesized; hydrolytic conditions were established; and extraction, derivatization and GC conditions were developed for analysis of these pyrethroid acid metabolites at ≥0.01 ppm on dry tea. GC/mass spectrometry was used to confirm assignment of residues found in some tea samples.

Determination of paroxetine levels in human plasma using gas chromatography with electron-capture detection

2000 ◽  
Vol 749 (2) ◽  
pp. 275-279 ◽  
Author(s):  
Chien-Tsai Lai ◽  
Emily S Gordon ◽  
Sidney H Kennedy ◽  
Alan N Bateson ◽  
Ronald T Coutts ◽  
...  
Keyword(s):  
Gas Chromatography ◽  
Human Plasma ◽  
Electron Capture ◽  
Electron Capture Detection
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