Poor correlation between erythrocytic 5-aminolevulinic acid dehydratase activity and blood lead concentration in a group of eleven-year-old children.

In comparison with control animals, a significant negative correlation (r = 0.77 -), between lead level and the activity of daminolevulinic acid dehydratase activity in the blood of land turtle (Testudo hermanni, Gmel.) caught in five different localities from heavy polluted environment of lead and zinc smelter “Trepca” was found. The concentration ratio of lead level in blood between control animals and those from the vicinity of smelter was 10:160 % and ratio of ALA-D activity was 10:18,3 U/LE.

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Recovery of Blood Lead Concentration and of Red Cell 8-Aminolevulinic Acid Dehydrase Activity in Dogs Following Return to Normal Diets after 75 Weeks of Lead Feeding

AIHAJ ◽

10.1080/0002889758507235 ◽

1975 ◽

Vol 36 (3) ◽

pp. 193-206 ◽

Cited By ~ 3

Author(s):

MARY E. MAXFIELD ◽

GORDON J. STOPPS ◽

JOHN R. BARNES ◽

RONALD D. SNEE ◽

MARY FINAN ◽

...

Keyword(s):

Lead Concentration ◽

Aminolevulinic Acid ◽

Blood Lead ◽

Blood Lead Concentration ◽

Red Cell

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Lead concentration and σ-aminolevulinic acid dehydratase activity in the blood of the general population of Tarragona Province, Spain

The Science of The Total Environment ◽

10.1016/0048-9697(92)90453-y ◽

1992 ◽

Vol 116 (3) ◽

pp. 253-259 ◽

Cited By ~ 7

Author(s):

M. Schuhmacher ◽

J.L. Domingo ◽

J.M. Llobet ◽

J. Corbella

Keyword(s):

General Population ◽

Lead Concentration ◽

Aminolevulinic Acid ◽

Acid Dehydratase ◽

Dehydratase Activity

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Blood lead level (BLL), δ-aminolevulinic acid dehydratase activity (ALAD), hemoglobin (Hb) and hematocrit (hct) in primary school-children and adult residents living in smelter rural areas in Kosovo

Journal of Environmental Science and Health Part A ◽

10.1080/10934529.2020.1780851 ◽

2020 ◽

Vol 55 (10) ◽

pp. 1179-1187

Author(s):

Mirlinda Dehari-Zeka ◽

Kasum Rr. Letaj ◽

Qerim I. Selimi ◽

Isa R. Elezaj

Keyword(s):

Primary School ◽

School Children ◽

Rural Areas ◽

Blood Lead Level ◽

Aminolevulinic Acid ◽

Lead Level ◽

Blood Lead ◽

Primary School Children ◽

Acid Dehydratase ◽

Dehydratase Activity

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Erythrocyte δ-aminolaevulinic Acid Dehydratase Activity and Blood Protoporphyrin Concentrations as Indices of Lead Exposure and Altered Haem Biosynthesis

Clinical Science ◽

10.1042/cs0560061 ◽

1979 ◽

Vol 56 (1) ◽

pp. 61-69 ◽

Cited By ~ 14

Author(s):

P. A. Meredith ◽

M. R. Moore ◽

A. Goldberg

Keyword(s):

Lead Exposure ◽

Lead Concentration ◽

False Negative ◽

Blood Lead ◽

Blood Lead Concentration ◽

Least Squares Regression ◽

Exponential Relationship ◽

Aminolaevulinic Acid ◽

Dehydratase Activity ◽

Ala Dehydratase

1. The activity of erythrocyte δ-aminolaevulinic acid (ALA) dehydratase and blood protoporphyrin concentrations have been measured in patients with various anaemias, a group of subjects with known lead exposure and a group of control subjects. Leucocyte ALA synthase was measured in subjects from the last two groups. 2. Erythrocyte ALA dehydratase activity was significantly depressed in the group of lead-exposed subjects and showed a highly significant negative exponential relationship with blood lead concentration. 3. Blood protoporphyrin concentrations were significantly elevated in the group of lead-exposed subjects and patients with iron-deficiency anaemia and showed a significant positive exponential relationship with blood lead concentration. 4. Comparison of the least-squares regression analysis of these relationships and incidence of false positive and false negative results indicates that erythrocyte ALA dehydratase activity is a more accurate measure of environmental and moderate industrial lead exposure than blood protoporphyrin concentrations. 5. The correlations of erythrocyte ALA dehydratase and leucocyte ALA synthase activity, and of blood protoporphyrin concentrations and leucocyte ALA synthase activity, suggest that blood protoporphyrin more accurately reflects haem synthesis than does erythrocyte ALA dehydratase activity.

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