Excretion of a Toxic Dose of Thallium

Abstract We report a successfully treated case of severe thallium intoxication that required 95 days of assisted ventilation and 224 days of hospitalization. Monitoring of the patient for 500 days by measuring thallium in whole blood, serum, and urine is documented, and the role of the laboratory and utility of the measurements are considered.

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Albumin as marker for susceptibility to metal ions in metal-on-metal hip prosthesis patients

Human & Experimental Toxicology ◽

10.1177/0960327116650011 ◽

2016 ◽

Vol 36 (4) ◽

pp. 319-327 ◽

Cited By ~ 2

Author(s):

F Facchin ◽

S Catalani ◽

E Bianconi ◽

D De Pasquale ◽

S Stea ◽

...

Keyword(s):

Health Status ◽

Blood Serum ◽

Whole Blood ◽

Metal Binding ◽

Hip Prosthesis ◽

Binding Capacity ◽

Gene Mutations ◽

Individual Susceptibility ◽

Metal On Metal ◽

Serum And Urine

Metal-on-metal (MoM) hip prostheses are known to release chromium and cobalt (Co), which negatively affect the health status, leading to prosthesis explant. Albumin (ALB) is the main serum protein-binding divalent transition metals. Its binding capacity can be affected by gene mutations or modification of the protein N-terminal region, giving the ischaemia-modified albumin (IMA). This study evaluated ALB, at gene and protein level, as marker of individual susceptibility to Co in MoM patients, to understand whether it could be responsible for the different management of this ion. Co was measured in whole blood, serum and urine of 40 MoM patients. A mutational screening of ALB was performed to detect links between mutations and metal binding. Finally, serum concentration of total ALB and IMA were measured. Serum total ALB concentration was in the normal range for all patients. None of the subjects presented mutations in the investigated gene. Whole blood, serum and urine Co did not correlate with serum total ALB or IMA, although IMA was above the normal limit in most subjects. The individual susceptibility is very important for patients’ health status. Despite the limited results of this study, we provide indications on possible future investigations on the toxicological response to Co.

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Element assessment in whole blood, serum and urine of three Italian healthy sub-populations by INAA

Microchemical Journal ◽

10.1016/j.microc.2011.07.008 ◽

2011 ◽

Vol 99 (2) ◽

pp. 548-555 ◽

Cited By ~ 24

Author(s):

P. Avino ◽

G. Capannesi ◽

M. Manigrasso ◽

E. Sabbioni ◽

A. Rosada

Keyword(s):

Blood Serum ◽

Whole Blood ◽

Serum And Urine

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Organophosphate esters and their metabolites in paired human whole blood, serum, and urine as biomarkers of exposure

Environment International ◽

10.1016/j.envint.2020.105698 ◽

2020 ◽

Vol 139 ◽

pp. 105698 ◽

Cited By ~ 9

Author(s):

Minmin Hou ◽

Yali Shi ◽

Qi Jin ◽

Yaqi Cai

Keyword(s):

Blood Serum ◽

Whole Blood ◽

Organophosphate Esters ◽

Human Whole Blood ◽

Biomarkers Of Exposure ◽

Serum And Urine

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Role of biobanking in managing large-scale epidemiological studies

CARDIOVASCULAR THERAPY AND PREVENTION ◽

10.15829/1728-8800-2021-2958 ◽

2021 ◽

Vol 20 (5) ◽

pp. 2958

Author(s):

M. S. Pokrovskaya ◽

A. L. Borisova ◽

V. A. Metelskaya ◽

I. A. Efimova ◽

Yu. V. Doludin ◽

...

Keyword(s):

Blood Serum ◽

Whole Blood ◽

Large Scale ◽

Venous Blood ◽

Epidemiological Studies ◽

National Medical ◽

And Storage ◽

Large Scale Epidemiological Study

The success and quality of large-scale epidemiological studies depends entirely on biomaterial quality. Therefore, when arranging the third Epidemiology of Cardiovascular Diseases and their Risk Factors in Regions of Russian Federation (ESSE-RF-3) study, increased attention was paid to specifics of collection, processing and further transportation of biological samples and related clinical and anthropometric data of participants from regional collection centers to Biobank.Aim. To develop a methodology for collection of high-quality biomaterials within the large-scale epidemiological study, involving the sampling, processing, freezing of blood and its derivatives (serum, plasma) in the regions, followed by transportation and storage of obtained biomaterial in the Biobank of National Medical Research Center for Therapy and Preventive Medicine (Moscow).Material and methods. To conduct the ESSE-RF-3 study, a design was developed, according to which the collection of venous blood samples in a total volume of 29,5 ml from each participant is planned in all participating regions in order to obtain and store samples of whole blood, serum and two types of plasma.Results. On the basis of international biobanking standards, ethical norms, experience from ESSE-RF and ESSE-RF-2, and literature data, a protocol for biobanking of blood and its derivatives was developed. The type and number of serum and plasma aliquots obtained, the required standard technical means and consumables, as well as logistic biomaterial requirements were determined. Training programs for regional participants were developed. By the beginning of August 2021, 180 thousand samples of whole blood, serum and plasma from more than 23 thousand participants from 28 Russian regions were collected, processed and stored.Conclusion. The presented work made it possible to assess and confirm the compliance of developed biobanking protocol with quality requirements. However, due to the coronavirus disease 2019 pandemic, by August 2021, the Biobank did not reach the maximum effectiveness predicted for the ESSE-RF-3 project.

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