Total and regional coronary blood flow during acute right ventricular pressure overload

1974 ◽  
Vol 8 (5) ◽  
pp. 611-620 ◽  
Author(s):  
R. J. DOMENECH ◽  
A. H. AYUY
Keyword(s):  
Blood Flow ◽  
Right Ventricular ◽  
Coronary Blood Flow ◽  
Pressure Overload ◽  
Ventricular Pressure

Effect of systole on coronary pressure-flow relations in the right ventricle of the dog

1980 ◽  
Vol 238 (4) ◽  
pp. H481-H486 ◽  
Author(s):  
R. F. Bellamy ◽  
H. S. Lowensohn
Keyword(s):  
Blood Flow ◽  
Right Ventricular ◽  
Coronary Blood Flow ◽  
Reactive Hyperemia ◽  
Systolic Pressure ◽  
Aortic Pressure ◽  
Ventricular Pressure ◽  
Pressure Flow ◽  
Ventricular Systole ◽  
Coronary Pressure

Downey and Kirk's hypothesis that ventricular systole inhibits coronary blood flow by forming vascular waterfalls was examined in conscious chronically instrumented dogs by studying the effect of right ventricular systole on right coronary blood flow. Diastolic and systolic pressure-flow relations were constructed at resting-level flow and peak flow reactive hyperemia from phasic pressure and flow tracings recorded in nine dogs with right ventricular pressures ranging between 14 and 154 mmHg. Linear relations were found between aortic pressure and right coronary flow during diastolic and during systole when peak ventricular pressure was less than systemic. At resting-level flow and when peak ventricular pressure was less than one-half systemic, systole translated the diastolic relation to a higher zero-flow-intercept pressure and did not alter the slope of the relation. We interpret the data as showing that ventricular systole inhibits coronary blood flow by augmenting a vascular waterfall mechanism that exists during diastole.

209 Premature changes in left ventricular gene-expression of SERCA2a and phospholamban induced by right ventricular pressure overload

2003 ◽  
Vol 2 (1) ◽  
pp. 43-44
Author(s):  
R RONCONALBUQUERQUE ◽  
T HENRIQUESCOELHO ◽  
M VASCONCELOS ◽  
A TELES ◽  
A LEITEMOREIRA
Keyword(s):  
Gene Expression ◽  
Right Ventricular ◽  
Pressure Overload ◽  
Left Ventricular ◽  
Ventricular Pressure

Regional Left Ventricular Systolic Function in Relation to the Cavity Geometry in Patients With Chronic Right Ventricular Pressure Overload

Circulation ◽  
1995 ◽  
Vol 91 (9) ◽  
pp. 2359-2370 ◽  
Author(s):  
Sheng-Jing Dong ◽  
Adrian P. Crawley ◽  
John H. MacGregor ◽  
Yael Fisher Petrank ◽  
Dale W. Bergman ◽  
...  
Keyword(s):  
Right Ventricular ◽  
Systolic Function ◽  
Pressure Overload ◽  
Left Ventricular Systolic Function ◽  
Left Ventricular ◽  
Ventricular Pressure ◽  
Ventricular Systolic Function

Decreased Myocyte Tension Development and Calcium Responsiveness in Rat Right Ventricular Pressure Overload

Circulation ◽  
1997 ◽  
Vol 95 (9) ◽  
pp. 2312-2317 ◽  
Author(s):  
Dongsheng Fan ◽  
Thomas Wannenburg ◽  
Pieter P. de Tombe
Keyword(s):  
Right Ventricular ◽  
Pressure Overload ◽  
Ventricular Pressure ◽  
Tension Development

Contribution of extravascular compression to reduction of maximal coronary blood flow

1992 ◽  
Vol 262 (1) ◽  
pp. H68-H77
Author(s):  
F. L. Abel ◽  
R. R. Zhao ◽  
R. F. Bond
Keyword(s):  
Blood Flow ◽  
Coronary Blood Flow ◽  
Coronary Flow ◽  
Perfusion Pressure ◽  
Left Ventricular Pressure ◽  
Coronary Perfusion Pressure ◽  
Left Ventricular ◽  
Ventricular Pressure ◽  
Coronary Perfusion ◽  
Storage Site

Effects of ventricular compression on maximally dilated left circumflex coronary blood flow were investigated in seven mongrel dogs under pentobarbital anesthesia. The left circumflex artery was perfused with the animals' own blood at a constant pressure (63 mmHg) while left ventricular pressure was experimentally altered. Adenosine was infused to produce maximal vasodilation, verified by the hyperemic response to coronary occlusion. Alterations of peak left ventricular pressure from 50 to 250 mmHg resulted in a linear decrease in total circumflex flow of 1.10 ml.min-1 x 100 g heart wt-1 for each 10 mmHg of peak ventricular to coronary perfusion pressure gradient; a 2.6% decrease from control levels. Similar slopes were obtained for systolic and diastolic flows as for total mean flow, implying equal compressive forces in systole as in diastole. Increases in left ventricular end-diastolic pressure accounted for 29% of the flow changes associated with an increase in peak ventricular pressure. Doubling circumferential wall tension had a minimal effect on total circumflex flow. When the slopes were extrapolated to zero, assuming linearity, a peak left ventricular pressure of 385 mmHg greater than coronary perfusion pressure would be required to reduce coronary flow to zero. The experiments were repeated in five additional animals but at different perfusion pressures from 40 to 160 mmHg. Higher perfusion pressures gave similar results but with even less effect of ventricular pressure on coronary flow or coronary conductance. These results argue for an active storage site for systolic arterial flow in the dilated coronary system.

scholarly journals Biventricular Remodeling in Murine Models of Right Ventricular Pressure Overload

PLoS ONE ◽  
2013 ◽  
Vol 8 (7) ◽  
pp. e70802 ◽  
Author(s):  
Navin K. Kapur ◽  
Vikram Paruchuri ◽  
Mark J. Aronovitz ◽  
Xiaoying Qiao ◽  
Emily E. Mackey ◽  
...  
Keyword(s):  
Right Ventricular ◽  
Pressure Overload ◽  
Ventricular Pressure ◽  
Murine Models

scholarly journals Progressive right ventricular failure is not explained by myocardial ischemia in a pig model of right ventricular pressure overload

2009 ◽  
Vol 35 (2) ◽  
pp. 229-234 ◽  
Author(s):  
Jan D. Schmitto ◽  
Hilmar Doerge ◽  
Heiner Post ◽  
Marlon Coulibaly ◽  
Christian Sellin ◽  
...  
Keyword(s):  
Myocardial Ischemia ◽  
Right Ventricular ◽  
Pressure Overload ◽  
Right Ventricular Failure ◽  
Pig Model ◽  
Ventricular Pressure ◽  
Ventricular Failure
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