scholarly journals Deoxycorticosterone acetate-salt hypertension activates placental growth factor in the spleen to couple sympathetic drive and immune system activation

2018 ◽  
Vol 114 (3) ◽  
pp. 456-467 ◽  
Author(s):  
Marialuisa Perrotta ◽  
Andrea Lori ◽  
Lorenzo Carnevale ◽  
Stefania Fardella ◽  
Giuseppe Cifelli ◽  
...  
Keyword(s):  
Immune System ◽  
Growth Factor ◽  
Placental Growth Factor ◽  
Deoxycorticosterone Acetate ◽  
Immune System Activation ◽  
Acetate Salt ◽  
Salt Hypertension ◽  
System Activation

Kinin-Mediated Antihypertensive Effect of Captopril in Deoxycorticosterone Acetate–Salt Hypertension

Hypertension ◽  
1996 ◽  
Vol 27 (1) ◽  
pp. 85-89 ◽  
Author(s):  
Ke Chen ◽  
Xuewei Zhang ◽  
Earl W. Dunham ◽  
Ben G. Zimmerman
Keyword(s):  
Antihypertensive Effect ◽  
Deoxycorticosterone Acetate ◽  
Acetate Salt ◽  
Salt Hypertension

scholarly journals Balloon cells promote immune system activation in focal cortical dysplasia type 2B

2021 ◽  
Author(s):  
Till S. Zimmer ◽  
Diede W.M. Broekaart ◽  
Mark Luinenburg ◽  
Caroline Mijnsbergen ◽  
Jasper J. Anink ◽  
...  
Keyword(s):  
Immune System ◽  
Focal Cortical Dysplasia ◽  
Cortical Dysplasia ◽  
Balloon Cells ◽  
Immune System Activation ◽  
System Activation

scholarly journals Expression of Phosphocitrate-Targeted Genes in Osteoarthritis Menisci

2014 ◽  
Vol 2014 ◽  
pp. 1-17 ◽  
Author(s):  
Yubo Sun ◽  
David R. Mauerhan ◽  
Nury M. Steuerwald ◽  
Jane Ingram ◽  
Jeffrey S. Kneisl ◽  
...  
Keyword(s):  
Immune System ◽  
Molecular Mechanisms ◽  
Fibroblast Growth Factor Receptor ◽  
Collagen Type ◽  
Skeletal Development ◽  
Growth Factor Receptor ◽  
Type Ii ◽  
Immune System Activation ◽  
System Activation ◽  
Disease Modifying

Phosphocitrate (PC) inhibited calcium crystal-associated osteoarthritis (OA) in Hartley guinea pigs. However, the molecular mechanisms remain elusive. This study sought to determine PC targeted genes and the expression of select PC targeted genes in OA menisci to test hypothesis that PC exerts its disease modifying activity in part by reversing abnormal expressions of genes involved in OA. We found that PC downregulated the expression of numerous genes classified in immune response, inflammatory response, and angiogenesis, including chemokine (C-C motif) ligand 5, Fc fragment of IgG, low affinity IIIb receptor (FCGR3B), and leukocyte immunoglobulin-like receptor, subfamily B member 3 (LILRB3). In contrast, PC upregulated the expression of many genes classified in skeletal development, including collagen type II alpha1, fibroblast growth factor receptor 3 (FGFR3), and SRY- (sex determining region Y-) box 9 (SOX-9). Immunohistochemical examinations revealed higher levels of FCGR3B and LILRB3 and lower level of SOX-9 in OA menisci. These findings indicate that OA is a disease associated with immune system activation and decreased expression of SOX-9 gene in OA menisci. PC exerts its disease modifying activity on OA, at least in part, by targeting immune system activation and the production of extracellular matrix and selecting chondroprotective proteins.

scholarly journals Angiotensin Type 1a Receptors in the Subfornical Organ Are Required for Deoxycorticosterone Acetate-Salt Hypertension

Hypertension ◽  
2013 ◽  
Vol 61 (3) ◽  
pp. 716-722 ◽  
Author(s):  
Aline M. Hilzendeger ◽  
Martin D. Cassell ◽  
Deborah R. Davis ◽  
Harald M. Stauss ◽  
Allyn L. Mark ◽  
...  
Keyword(s):  
Subfornical Organ ◽  
Deoxycorticosterone Acetate ◽  
Acetate Salt ◽  
Salt Hypertension ◽  
Angiotensin Type

A mechanistic study of immune system activation by fusion of antigens with the ligand-binding domain of CTLA4

2006 ◽  
Vol 55 (12) ◽  
pp. 1504-1514 ◽  
Author(s):  
Dhanalakshmi Chinnasamy ◽  
Matt Tector ◽  
Nachimuthu Chinnasamy ◽  
Kate Dennert ◽  
Karen M. Kozinski ◽  
...  
Keyword(s):  
Immune System ◽  
Ligand Binding ◽  
Binding Domain ◽  
Ligand Binding Domain ◽  
Mechanistic Study ◽  
Immune System Activation ◽  
System Activation

The Vascular Ornithine Decarboxylase/Polyamine System in Deoxycorticosterone Acetate-Salt Hypertension

1994 ◽  
pp. 279-288
Author(s):  
E. E. Soltis ◽  
P. S. Newman ◽  
M. E. Brown ◽  
J. L. Trowbridge ◽  
H. Guo ◽  
...  
Keyword(s):  
Ornithine Decarboxylase ◽  
Deoxycorticosterone Acetate ◽  
Acetate Salt ◽  
Salt Hypertension

Chronic Caffeine Ingest ion Exacerbates 2-Kidney, 1-Clip Hypertension and Ameliorates Deoxycorticosterone Acetate-Salt Hypertension in Rats

Nephron ◽  
1993 ◽  
Vol 65 (4) ◽  
pp. 619-622 ◽  
Author(s):  
Ki Chul Choi ◽  
Jongeun Lee ◽  
Kyoung Hyup Moon ◽  
Kwang Ki Park ◽  
Soo Wan Kim ◽  
...  
Keyword(s):  
Deoxycorticosterone Acetate ◽  
Acetate Salt ◽  
Salt Hypertension ◽  
Chronic Caffeine
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