scholarly journals Case Report: Acute Myocarditis Following the Second Dose of Mrna-1273 Sars-Cov-2 Vaccine

2021 ◽  
Author(s):  
Prashant D Tailor ◽  
Aoife M Feighery ◽  
Bassim El-Sabawi ◽  
Abhiram Prasad
Keyword(s):  
Chest Pain ◽  
Cardiac Function ◽  
Acute Myocarditis ◽  
Complete Recovery ◽  
St Segment Elevation ◽  
St Segment ◽  
Post Marketing Surveillance ◽  
Post Marketing ◽  
Artery Disease

Abstract Background The SARS-CoV-2 pandemic has led to the development of the first mRNA vaccines used in humans. The vaccines are well tolerated, safe and highly efficacious; however, post marketing surveillance is revealing potential rare adverse effects. We report a case of symptomatic acute myocarditis following administration of the second dose of mRNA-1273 SARS-CoV-2 Vaccine. Case Summary A 44-year-old man presented with chest pain and ST-segment elevation four days after receiving a second dose of mRNA-1273 SARS-CoV-2 Vaccine. Emergent coronary angiogram showed minimal coronary artery disease. Cardiac magnetic resonance imaging confirmed acute myocarditis. Diagnosis of vaccine-associated myocarditis was made given the temporal relationship and supportive treatment initiated. Follow-up at one month confirmed complete symptomatic recovery and echocardiogram demonstrated normalization of cardiac function. Discussion Acute myocarditis should be considered in patients who present with chest pain or dyspnoea within days of receiving mRNA-1273 SARS-CoV-2 vaccination, especially after the second dose. This may be managed successfully with supportive therapies with complete recovery of cardiac function and symptoms. Further research is warranted to determine the mechanisms by which mRNA vaccines may cause myocarditis and for potential long-term cardiovascular injury.

scholarly journals ST Segment Elevation Is Not Always Myocardial Infarction: A Case of Focal Myopericarditis

2017 ◽  
Vol 2017 ◽  
pp. 1-4
Author(s):  
Cyrus M. Munguti ◽  
Samuel Akidiva ◽  
Jacob Wallace ◽  
Hussam Farhoud
Keyword(s):  
Myocardial Infarction ◽  
Coronary Artery Disease ◽  
Chest Pain ◽  
Coronary Artery ◽  
Coronary Angiography ◽  
Cardiac Mri ◽  
St Segment Elevation ◽  
St Segment ◽  
Normal Coronary Angiography ◽  
Artery Disease

Protocols exist on how to manage STEMI patients, with well-established timelines. There are times when patients present with chest pain, ST segment elevation, and biomarker elevation that are not due to coronary artery disease. These conditions usually present with normal coronary angiography. We present a case that was clinically indistinguishable from STEMI and that was diagnosed with focal myopericarditis on cardiac MRI.

A Lethal Side Effect of Treatment by Macitentan

2020 ◽  
Author(s):  
Oumaima Naour
Keyword(s):  
Chest Pain ◽  
Side Effects ◽  
Side Effect ◽  
Acute Myocarditis ◽  
Human Case ◽  
Double Outlet Right Ventricle ◽  
St Segment Elevation ◽  
Cardiac Side Effects ◽  
St Segment ◽  
Pulmonary Arterial

Pulmonary arterial hypertension is a progressive and ultimately fatal disease despite the availability of a number of new therapies, including endothelin receptor antagonists. Many side effects have been reported with the use of these drugs, such as hepatotoxicity, peripheral edema, anemia and other digestive reactions. Cardiac side effects have been rarely mentioned. We report the case of a 17-year-old girl with Eisenmenger syndrome secondary to double outlet right ventricle and sub-pulmonary ventricular septal defect, Macitentan treatment has been started, three days later, she presented a ST segment elevation in septo-apico- lateral territory which shortly complicated with cardiogenic shock and death. A coronary arteritis or acute myocarditis of toxic origin was the two evoked diagnoses. This is the first human case in the medical literature describing a relationship between initiation of Macitentan and the onset of this event. This case highlights a lethal side effect of Macitentan, which should prompt patients to notify their doctors of any symptoms suggestive of coronary or myocardial injury (chest pain, dyspnea, heart failure symptoms), and implementation of electrocardiogram in combination with a control in any patient who develops chest pain on Macitentan.

scholarly journals ST Segment Elevation and Depressions in Supraventricular Tachycardia without Coronary Artery Disease

2018 ◽  
Vol 2018 ◽  
pp. 1-3
Author(s):  
Fuad Habash ◽  
Arwa Albashaireh ◽  
Mohammed Eid Madmani ◽  
Hakan Paydak
Keyword(s):  
Chest Pain ◽  
Sinus Rhythm ◽  
Heart Catheterization ◽  
Left Heart ◽  
St Segment Elevation ◽  
Atrioventricular Reentrant Tachycardia ◽  
St Depression ◽  
Left Heart Catheterization ◽  
St Segment ◽  
Artery Disease

ST segment changes are well documented in literature during supraventricular tachycardias. We present a case of a 21-year-old male who presents with chest pain, shortness of breath, and dizziness with an ECG showing atrioventricular reentrant tachycardia and diffuse ST segment depressions. Patient spontaneously converted to sinus rhythm, but he was still complaining of crushing chest pain. ECG taken after conversion showed sinus rhythm at a rate of 65 and showed obvious persistence of ST depressions in majority of leads. Emergent left heart catheterization showed normal coronaries. Such ST depression is suggestive of global ischemia in small intracardiac vessels that cannot be evaluated by left heart catheterization.

scholarly journals To Be or Not to Be … Acute Coronary Syndrome

2016 ◽  
Vol 62 (3) ◽  
pp. 363-367
Author(s):  
Pintilie Irina ◽  
Scridon Alina ◽  
Șerban Răzvan Constantin
Keyword(s):  
Chest Pain ◽  
Troponin I ◽  
Enzyme Inhibitor ◽  
Acute Myocarditis ◽  
Ventricular Myocardium ◽  
Left Ventricular ◽  
Left Ventricular Myocardium ◽  
St Segment Elevation ◽  
Coronary Syndrome ◽  
St Segment

AbstractIntroduction: The association between ST segment abnormalities, elevated cardiac enzymes, and chest pain is usually a marker of acute coronary injury. However, certain other pathologies can sometimes mimic acute coronary syndromes.Case report: A 40-year-old Caucasian male, former smoker, with no other cardiovascular risk factors, presented to the Emergency Department for typical ischemic, prolonged chest pain. The ECG demonstrated inverted T waves in leads I, II, aVL, and V3 to V6. The patient presented high cardiac necrosis markers (troponin I 2.65 ng/ml). Based on these findings, the case was interpreted as non-ST segment elevation myocardial infarction, but coronary angiography excluded the presence of significant coronary lesions. The ventriculography showed an efficient left ventricle, with mild hypokinesia of the two apical thirds of the anterior left ventricular wall. Cardiac magnetic resonance imaging demonstrated areas of hypersignal on the T2-weighted imaging sequence in the left ventricular myocardium, suggestive for acute myocarditis. The patient was started on antiplatelet, beta-blocker, and angiotensin converting enzyme inhibitor, with favorable evolution.Conclusion: This case underlines the polymorphic appearance of acute myocarditis, which can often mimic an acute coronary event.

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