scholarly journals P3658Saline induced Pd/Pa ratio can predict functional significance of coronary stenosis assessed using fractional flow reserve

2018 ◽  
Vol 39 (suppl_1) ◽  
Author(s):  
S Hashimoto ◽  
Y Fujimori ◽  
T Baba ◽  
K Kurihara ◽  
K Ebisuda ◽  
...  
Keyword(s):  
Fractional Flow Reserve ◽  
Functional Significance ◽  
Coronary Stenosis ◽  
Fractional Flow ◽  
Flow Reserve

NEW CUT-OFF VALUE OF IVUS MINIMAL LUMEN AREA (MLA) AND FRACTIONAL FLOW RESERVE (FFR) TO DEFINE THE FUNCTIONAL SIGNIFICANCE OF DENOVO INTERMEDIATE CORONARY STENOSIS

2015 ◽  
pp. 11-19
Author(s):  
Minh Hung Ngo ◽  
Anh Tien Hoang ◽  
Cuu Long Nguyen ◽  
Thanh Nhan Vo ◽  
Phan Tuong Quynh Le ◽  
...  
Keyword(s):  
Intravascular Ultrasound ◽  
Fractional Flow Reserve ◽  
Functional Significance ◽  
Coronary Stenosis ◽  
Lumen Area ◽  
Plaque Volume ◽  
Fractional Flow ◽  
Flow Reserve ◽  
Minimal Lumen Area ◽  
Study Results

Background: Intravascular Ultrasound (IVUS) is a supportive tool for coronary angiography in evaluating intermediate coronary lesions. However, old cut-off value of 4mm2 of IVUS Minimal Lumen Area (MLA) has been proved very low diagnosic accuracy. Objective: We aimed to assess a new cut-off value of IVUS MLA and its diagnostic performance to predict ischemia, using fractional flow reserve (FFR) as gold standard. Methods: Denovo Intermediate lesions were evaluated with both IVUS and FFR. A total of 32 lesions were enrolled into the study. Results: Thirty two patients, who had denovo intermediate lesions distributing at prox-mid segment of RCA (31.3%), LAD (59.4%) and LCx (6.2%), were enrolled into this study, with average age: 63.97±11.59 (years), male: 71.9% and female: 28.1%, mean diameter stenosis: 50.68% ± 8.83 and mean reference diameter: 2.99 mm ± 0.61mm. IVUS MLA (r = 0.386, p < 0.014) correlated with FFR. The stenotic diameter (r = -0.159, p < 0.192), the length (r = -0.052, p = 0.389) and the plaque volume (r = -0.105, p = 0.284) didn’t well correlate with FFR. Best cut-off value (BCV) of IVUS MLA to define the functional significance (FFR ≤0.8) was 2.55 mm2 (AUC 0.776; 95% CI 0.607-0.946) with sensitivity and specitivity were 66.7% and 88.2% respectively. Conclusion: In this study, an IVUS MLA of 2.55 mm2 was the BCV to define the functional significance of denovo intermediate coronary stenosis. However, when IVUS MLA is used to determine the functional significance, both the lesion diameter and length should be considered. Key words: intermediate lesion, intravascular ultrasound (IVUS), Fractional Flow Reserve (FFR)

scholarly journals Saline-induced Pd/Pa ratio predicts functional significance of coronary stenosis assessed using fractional flow reserve

2018 ◽  
Vol 14 (8) ◽  
pp. 898-906 ◽  
Author(s):  
Yoshiharu Fujimori ◽  
Tomoko Baba ◽  
Kyohei Yamazaki ◽  
Satoshi Hashimoto ◽  
Yasushi Yamanaka ◽  
...  
Keyword(s):  
Fractional Flow Reserve ◽  
Functional Significance ◽  
Coronary Stenosis ◽  
Fractional Flow ◽  
Flow Reserve

SALINE INDUCED PD/PA RATIO CAN PREDICT FUNCTIONAL SIGNIFICANCE OF CORONARY STENOSIS ASSESSED BY FRACTIONAL FLOW RESERVE

2018 ◽  
Vol 71 (11) ◽  
pp. A18
Author(s):  
Satoshi Hashimoto ◽  
Yoshiharu Fujimori ◽  
Kyohei Yamazaki ◽  
Kazuto Kurihara ◽  
Kenichiro Ebisuda ◽  
...  
Keyword(s):  
Fractional Flow Reserve ◽  
Functional Significance ◽  
Coronary Stenosis ◽  
Fractional Flow ◽  
Flow Reserve

Fractional flow reserve

2021 ◽  
pp. 63-67
Author(s):  
Giovanni Ciccarelli ◽  
Emanuele Barbato ◽  
Bernard De Bruyne
Keyword(s):  
Blood Flow ◽  
Myocardial Blood Flow ◽  
Fractional Flow Reserve ◽  
Coronary Stenosis ◽  
Coronary Intervention ◽  
Aortic Pressure ◽  
Fractional Flow ◽  
Coronary Pressure ◽  
Flow Reserve ◽  
Percutaneous Coronary

Fractional flow reserve is an index of the physiological significance of a coronary stenosis, defined as the ratio of maximal myocardial blood flow in the presence of the stenosis to the theoretically normal maximal myocardial blood flow (i.e. in the absence of the stenosis). This flow ratio can be calculated from the ratio of distal coronary pressure to central aortic pressure during maximal hyperaemia. More practically, fractional flow reserve indicates to what extent the epicardial segment can be responsible for myocardial ischaemia and, accordingly, fractional flow reserve quantifies the expected perfusion benefit from revascularization by percutaneous coronary intervention. Very limited evidence exists on the role on fractional flow reserve for bypass grafts.

scholarly journals Meta-Analysis of Diagnostic Performance of Contrast-Fractional Flow Reserve versus Quantitative Flow Ratio for Functional Assessment of Coronary Stenoses

2020 ◽  
Vol 2020 ◽  
pp. 1-10
Author(s):  
Ruitao Zhang ◽  
Jianwei Zhang ◽  
Lijun Guo
Keyword(s):  
Sensitivity And Specificity ◽  
Fractional Flow Reserve ◽  
Coronary Stenosis ◽  
Diagnostic Performance ◽  
Meta Analysis ◽  
Flow Ratio ◽  
Fractional Flow ◽  
Flow Reserve ◽  
Quantitative Flow Ratio ◽  
Quantitative Flow

Background. Use of the fractional flow reserve (FFR) technique is recommended to evaluate coronary stenosis severity and guide revascularization. However, its high cost, time to administer, and the side effects of adenosine reduce its clinical utility. Two novel adenosine-free indices, contrast-FFR (cFFR) and quantitative flow ratio (QFR), can simplify the functional evaluation of coronary stenosis. This study aimed to analyze the diagnostic performance of cFFR and QFR using FFR as a reference index. Methods. We conducted a systematic review and meta-analysis of observational studies in which cFFR or QFR was compared to FFR. A bivariate model was applied to pool diagnostic parameters. Cochran’s Q test and the I2 index were used to assess heterogeneity and identify the potential source of heterogeneity by metaregression and sensitivity analysis. Results. Overall, 2220 and 3000 coronary lesions from 20 studies were evaluated by cFFR and QFR, respectively. The pooled sensitivity and specificity were 0.87 (95% CI: 0.81, 0.91) and 0.92 (95% CI: 0.88, 0.94) for cFFR and 0.87 (95% CI: 0.82, 0.91) and 0.91 (95% CI: 0.87, 0.93) for QFR, respectively. No statistical significance of sensitivity and specificity for cFFR and QFR were observed in the bivariate analysis (P=0.8406 and 0.4397, resp.). The area under summary receiver-operating curve of cFFR and QFR was 0.95 (95% CI: 0.93, 0.97) for cFFR and 0.95 (95% CI: 0.93, 0.97). Conclusion. Both cFFR and QFR have good diagnostic performance in detecting functional severity of coronary arteries and showed similar diagnostic parameters.

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