scholarly journals Exercise During Childhood Protects Against Cardiac Dysfunction Later in Life

2021 ◽  
Vol 5 (Supplement_1) ◽  
pp. 683-683
Author(s):  
Danielle Bruns ◽  
MacKenzie DeHoff ◽  
Aykhan Yusifov ◽  
Sydney Polson ◽  
Ross Cook ◽  
...  
Keyword(s):  
Wheel Running ◽  
Sedentary Control ◽  
Juvenile Period ◽  
Cardiac Stress ◽  
Female Mice ◽  
Aged Mice ◽  
Developing Heart ◽  
Ongoing Work ◽  
Aging Populations ◽  
Voluntary Wheel

Abstract Cardiovascular disease continues to be a major cause of morbidity and mortality, particularly in aging populations. Exercise is amongst the most cardioprotective interventions identified to date, with early in life exercise such as during the juvenile period potentially imparting even more cardioprotective outcomes due to the plasticity of the developing heart. To test the hypothesis that juvenile exercise would impart later in life cardioprotection, we exercised juvenile male and female mice via voluntary wheel running from 3-5 weeks of age and then exposed them to cardiac stress by isoproterenol (ISO) at 4-6 and 18 months of age in adulthood and older age, respectively. We compared cardiac function and remodeling to sedentary control animals, sedentary animals who received ISO, and adult and aged mice that exercised for two weeks immediately before ISO exposure. Juvenile mice engaged in voluntarily wheel running, with male mice running 1.3 ± 0.8 km and female mice 2.8 ± 1.0 km a day. Echocardiography suggested that these juvenile animals underwent running-induced cardiac remodeling as evidenced by higher ejection fraction and stroke volume compared to sedentary controls. Exercise in the juvenile period attenuated ISO-induced cardiac hypertrophy and remodeling later in life compared to sedentary animals and those that exercised immediately before ISO administration. The mechanisms by which early versus late exercise is protective in adult and aged mice are under investigation. Further ongoing work will identify the adaptations induced by exercise in the juvenile heart that may help improve cardiac aging.

scholarly journals Voluntary wheel running, but not a diet containing (−)-epigallocatechin-3-gallate and β-alanine, improves learning, memory and hippocampal neurogenesis in aged mice

2014 ◽  
Vol 272 ◽  
pp. 131-140 ◽  
Author(s):  
Trisha E. Gibbons ◽  
Brandt D. Pence ◽  
Geraldine Petr ◽  
Jessica M. Ossyra ◽  
Houston C. Mach ◽  
...  
Keyword(s):  
Wheel Running ◽  
Hippocampal Neurogenesis ◽  
Voluntary Wheel Running ◽  
Aged Mice ◽  
Voluntary Wheel

scholarly journals Voluntary Wheel Running Does Not Affect Lipopolysaccharide-Induced Depressive-Like Behavior in Young Adult and Aged Mice

2014 ◽  
Vol 21 (1) ◽  
pp. 52-63 ◽  
Author(s):  
Stephen A. Martin ◽  
Robert Dantzer ◽  
Keith W. Kelley ◽  
Jeffrey A. Woods
Keyword(s):  
Young Adult ◽  
Wheel Running ◽  
Voluntary Wheel Running ◽  
Aged Mice ◽  
Voluntary Wheel

scholarly journals Voluntary wheel running delays brain atrophy in aged mice

2019 ◽  
Vol 27 ◽  
pp. 175-184
Author(s):  
Lan Lin ◽  
Zhenrong Fu ◽  
Yuchao Wu ◽  
Shuicai Wu
Keyword(s):  
Brain Atrophy ◽  
Wheel Running ◽  
Voluntary Wheel Running ◽  
Aged Mice ◽  
Voluntary Wheel

Effects of exercise and dietary epigallocatechin gallate and β-alanine on skeletal muscle in aged mice

2016 ◽  
Vol 41 (2) ◽  
pp. 181-190 ◽  
Author(s):  
Brandt D. Pence ◽  
Trisha E. Gibbons ◽  
Tushar K. Bhattacharya ◽  
Houston Mach ◽  
Jessica M. Ossyra ◽  
...  
Keyword(s):  
Gene Expression ◽  
Grip Strength ◽  
Muscle Function ◽  
Dietary Intervention ◽  
Wheel Running ◽  
Sirtuin 1 ◽  
Voluntary Wheel Running ◽  
Aged Mice ◽  
Regulated Gene Expression ◽  
Voluntary Wheel

Aging leads to sarcopenia and loss of physical function. We examined whether voluntary wheel running, when combined with dietary supplementation with (−)-epigallocatechin-3-gallate (EGCG) and β-alanine (β-ALA), could improve muscle function and alter gene expression in the gastrocnemius of aged mice. Seventeen-month-old BALB/cByJ mice were given access to a running wheel or remained sedentary for 41 days while receiving either AIN-93M (standard feed) or AIN-93M containing 1.5 mg·kg−1 EGCG and 3.43 mg·kg−1 β-ALA. Mice underwent tests over 11 days from day 29 to day 39 of the study period, including muscle function testing (grip strength, treadmill exhaustive fatigue, rotarod). Following a rest day, mice were euthanized and gastrocnemii were collected for analysis of gene expression by quantitative PCR. Voluntary wheel running (VWR) improved rotarod and treadmill exhaustive fatigue performance and maintained grip strength in aged mice, while dietary intervention had no effect. VWR increased gastrocnemius expression of several genes, including those encoding interleukin-6 (Il6, p = 0.001), superoxide dismutase 1 (Sod1, p = 0.046), peroxisome proliferator-activated receptor gamma coactivator 1-α (Ppargc1a, p = 0.013), forkhead box protein O3 (Foxo3, p = 0.005), and brain-derived neurotrophic factor (Bdnf, p = 0.008), while reducing gastrocnemius levels of the lipid peroxidation marker 4-hydroxynonenal (p = 0.019). Dietary intervention alone increased gastrocnemius expression of Ppargc1a (p = 0.033) and genes encoding NAD-dependent protein deacetylase sirtuin-1 (Sirt1, p = 0.039), insulin-like growth factor I (Igf1, p = 0.003), and macrophage marker CD11b (Itgam, p = 0.016). Exercise and a diet containing β-ALA and EGCG differentially regulated gene expression in the gastrocnemius of aged mice, while VWR but not dietary intervention improved muscle function. We found no synergistic effects between dietary intervention and VWR.

scholarly journals Wnt Protein-mediated Satellite Cell Conversion in Adult and Aged Mice Following Voluntary Wheel Running

2014 ◽  
Vol 289 (11) ◽  
pp. 7399-7412 ◽  
Author(s):  
Shin Fujimaki ◽  
Ryo Hidaka ◽  
Makoto Asashima ◽  
Tohru Takemasa ◽  
Tomoko Kuwabara
Keyword(s):  
Satellite Cell ◽  
Wheel Running ◽  
Voluntary Wheel Running ◽  
Aged Mice ◽  
Cell Conversion ◽  
Voluntary Wheel

Voluntary wheel running reduces colon inflammation in female but not male mice fed a high-fat diet

2019 ◽  
Vol 15 (1) ◽  
pp. 35-47
Author(s):  
P.J. Wisniewski ◽  
G. Wahler ◽  
C. Gardner ◽  
S.A. Lightfoot ◽  
L.B. Joseph ◽  
...  
Keyword(s):  
High Fat Diet ◽  
Wheel Running ◽  
Distal Colon ◽  
High Fat ◽  
Spatial Organisation ◽  
Epithelial Surface ◽  
Voluntary Wheel Running ◽  
Female Mice ◽  
Mucin 2 ◽  
Voluntary Wheel

The influence of diet and exercise on intestinal mucus and the spatial organisation of the microbiota is poorly understood. Though, it has been observed that the spatial organisation of the microbiota can be altered extensively in Crohn’s disease and ulcerative colitis. This study aims to investigate the pathophysiological events in mouse colon that are associated with a high fat diet and lack of exercise. Forty-eight, 6-week old C57BL/6NTac male and female mice were fed a normal or high-fat diet for 12 weeks and randomly assigned to free wheel running or sedentary groups. After 12 weeks, animals were sacrificed and distal colon tissue sections with and without faecal material were fixed for histomorphometric analysis, immunohistochemistry for cyclooxygenase-2 and mucin-2, or fluorescent in situ hybridization with the universal bacterial probe EUB338 (5’-GCTGCCTCCCGTAGGAGT-3’). Goblet cell counts and distance between the microbiota and epithelial surface were determined using ImageJ software. All mice had a normal colon morphology except for high-fat fed female mice who ran, demonstrating a reduction of goblet cells that approached significance and a reduced mucin-2 expression. Voluntary wheel running attenuated high-fat diet induced COX-2 expression in female mice only. The distance between the microbiota and epithelial surface remained the same. Taken together, these results show that voluntary wheel running protect against high-fat diet-induced inflammation in the distal colon of female mice and responses to changes in host behaviour may differ between sex.

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