scholarly journals 505Maternal autoimmune disease and increased attention deficit/hyperactivity disorder among offspring: A cohort study and meta-analysis

2021 ◽  
Vol 50 (Supplement_1) ◽  
Author(s):  
Timothy Nielsen ◽  
Natasha Nassar ◽  
Antonia Shand ◽  
Russell Dale ◽  
Samantha Lain
Keyword(s):  
Attention Deficit Hyperactivity Disorder ◽  
Autoimmune Disease ◽  
Propensity Score ◽  
Attention Deficit ◽  
Cox Regression ◽  
Meta Analysis ◽  
Population Based ◽  
Prescription Data ◽  
Cox Regression Analysis ◽  
Hyperactivity Disorder

Abstract Background Maternal autoimmune disease (AD) has been associated with increased neurodevelopmental disorders in the offspring, but few studies have assessed Attention Deficit/Hyperactivity Disorder (ADHD). Methods Population-based record linkage study of 831,718 singleton term births in New South Wales, Australia, 2000-2010. Any maternal AD and specific autoimmune conditions were identified from hospital admission data, and ADHD in children was ascertained from stimulant prescription data (up to 2014). The association between maternal AD and ADHD was examined using Cox regression analysis after propensity score matching (1:4) to control for maternal confounders. A systematic review and meta-analyses were conducted, and pooled hazard ratios (HR) were calculated using random-effects meta-analysis with inverse variance weights. Results Of 831,718 births, 12,767 (1.5%) women had AD. In a propensity score-matched cohort (n = 63,050) maternal AD was associated with ADHD in offspring: “any AD” (HR 1.30, 95%CI 1.15-1.46), type-1 diabetes (T1D) (HR 2.23, 95%CI 1.66-3.00), psoriasis (HR 1.66, 95%CI 1.02-2.70) and rheumatic fever/carditis (HR 1.75, 95%CI 1.06-2.89). Five studies including ours were identified and included in the meta-analysis. Any AD (2 studies: HR 1.20, 95%CI 1.03-1.38), T1D (4 studies: HR 1.53, 95%CI 1.27-1.85), hyperthyroidism (3 studies: HR 1.15, 95%CI 1.06-1.26), and psoriasis (2 studies: HR 1.31, 95%CI 1.10-1.56) were associated with ADHD. Conclusions Maternal ADs were associated with increased ADHD among offspring, suggesting shared underlying genetic vulnerability or a role for maternal immune activation in fetal neurodevelopment. Future studies are required to understand causal mechanisms and identify interventions. Key messages Maternal ADs are associated with increased ADHD among offspring.

scholarly journals A Genome-Wide Association Meta-Analysis of Attention-Deficit/Hyperactivity Disorder Symptoms in Population-Based Pediatric Cohorts

2016 ◽  
Vol 55 (10) ◽  
pp. 896-905.e6 ◽  
Author(s):  
Christel M. Middeldorp ◽  
Anke R. Hammerschlag ◽  
Klaasjan G. Ouwens ◽  
Maria M. Groen-Blokhuis ◽  
Beate St. Pourcain ◽  
...  
Keyword(s):  
Attention Deficit Hyperactivity Disorder ◽  
Attention Deficit ◽  
Meta Analysis ◽  
Population Based ◽  
Genome Wide Association ◽  
Hyperactivity Disorder ◽  
Genome Wide ◽  
A Genome

scholarly journals Increased Alopecia Areata Risk in Children with Attention-Deficit/Hyperactivity Disorder and the Impact of Methylphenidate Use: A Nationwide Population-Based Cohort Study

2021 ◽  
Vol 18 (3) ◽  
pp. 1286
Author(s):  
Hsing-Ying Ho ◽  
Chih-Kai Wong ◽  
Szu-Yuan Wu ◽  
Ray C. Hsiao ◽  
Yi-Lung Chen ◽  
...  
Keyword(s):  
Attention Deficit Hyperactivity Disorder ◽  
Alopecia Areata ◽  
Attention Deficit ◽  
Cox Regression ◽  
Population Based ◽  
Children With Adhd ◽  
Hyperactivity Disorder ◽  
Health Database ◽  
Underlying Mechanisms ◽  
The Impact

Alopecia areata (AA) is an autoimmune disease that causes sudden hair loss. Although few studies have reported the association between AA and attention-deficit/hyperactivity disorder (ADHD), the impact of methylphenidate (MPH) on AA has not been examined. This study examined whether AA risk is higher in children with ADHD than in those without ADHD as well as the impact of MPH use on AA risk in children with ADHD. From the Taiwan Maternal and Child Health Database, we enrolled all 1,750,456 newborns from 2004 to 2017 in Taiwan. Of them, 90,016 children received a diagnosis of ADHD whereas the remaining 1,660,440 did not. To compare AA risk in ADHD and the impact of MPH treatment on it, multiple Cox regression with adjustments for covariates (i.e., age, sex, and psychiatric comorbidities) was performed. The results indicated that 88 (0.098%) children with ADHD and 1191 (0.072%) children without ADHD had AA. Nevertheless, after adjustment for the covariates, AA risk was higher in children with ADHD than in those without ADHD (adjusted hazard ratio [aHR]: 1.30, 95% confidence interval [CI]: 1.04–1.64). Our data indicated a considerable reduction in AA risk (aHR: 0.64) among children with ADHD who received MPH than among those who did not receive MPH; however, this difference was nonsignificant, indicated by a wide 95% CI (0.32–1.25). In conclusion, ADHD and AA may share some underlying mechanisms.

scholarly journals Maternal pre-pregnancy overweight/obesity and the risk of attention-deficit/hyperactivity disorder in offspring: a systematic review, meta-analysis and quasi-experimental family-based study

2020 ◽  
Vol 49 (3) ◽  
pp. 857-875
Author(s):  
Lin Li ◽  
Tyra Lagerberg ◽  
Zheng Chang ◽  
Samuele Cortese ◽  
Mina A Rosenqvist ◽  
...  
Keyword(s):  
Systematic Review ◽  
Attention Deficit Hyperactivity Disorder ◽  
Attention Deficit ◽  
Meta Analysis ◽  
Population Based ◽  
Cox Models ◽  
Random Effects Models ◽  
Hyperactivity Disorder ◽  
Increased Risk ◽  
Maternal Overweight

Abstract Background Previous studies are inconclusive concerning the association between maternal pre-pregnancy overweight/obesity and risk of attention-deficit/hyperactivity disorder (ADHD) in offspring. We therefore conducted a systematic review and meta-analysis to clarify this association. To address the variation in confounding adjustment between studies, especially inadequate adjustment of unmeasured familial confounding in most studies, we further performed cousin and sibling comparisons in a nationwide population-based cohort in Sweden. Methods We searched PubMed, Embase and PsycINFO during 1975–2018. We used random-effects models to calculate pooled risk ratios (RRs) with 95% confidence interval. In the population-based study, Cox proportional hazard models were used to calculate the unadjusted hazard ratios (HRs) and HRs adjusted for all confounders identified in previous studies. Stratified Cox models were applied to data on full cousins and full siblings to further control for unmeasured familial confounding. Results Eight cohorts with a total of 784 804 mother–child pairs were included in the meta-analysis. Maternal overweight [RRoverweight = 1.31 (1.25–1.38), I2 = 6.80%] and obesity [RRobesity = 1.92 (1.84–2.00), I2 = 0.00%] were both associated with an increased risk of ADHD in offspring. In the population-based cohort of 971 501 individuals born between 1992 and 2004, unadjusted Cox models revealed similar associations [HRoverweight = 1.30 (1.28–1.34), HRobesity = 1.92 (1.87–1.98)]. These associations gradually attenuated towards the null when adjusted for measured confounders [HRoverweight = 1.21 (1.19–1.25), HRobesity = 1.60 (1.55–1.65)], unmeasured factors shared by cousins [HRoverweight = 1.10 (0.98–1.23), HRobesity = 1.44 (1.22–1.70)] and unmeasured factors shared by siblings [HRoverweight = 1.01 (0.92–1.11), HRobesity = 1.10 (0.94–1.27)]. Conclusion Pre-pregnancy overweight/obesity is associated with an increased risk of ADHD in offspring. The observed association is largely due to unmeasured familial confounding.

A meta-analysis of malingering detection measures for attention-deficit/hyperactivity disorder.

2019 ◽  
Vol 31 (2) ◽  
pp. 265-270 ◽  
Author(s):  
Elizabeth R. Wallace ◽  
Natasha E. Garcia-Willingham ◽  
Brittany D. Walls ◽  
Chelsea M. Bosch ◽  
Kullen C. Balthrop ◽  
...  
Keyword(s):  
Attention Deficit Hyperactivity Disorder ◽  
Attention Deficit ◽  
Meta Analysis ◽  
Hyperactivity Disorder ◽  
Malingering Detection
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