Clinical Evaluation of Adenine Arabinoside and Triftuorothymidine in the Treatment of Corneal Ulcers Caused by Herpes Simplex Virus

1976 ◽  
Vol 133 (Supplement 2) ◽  
pp. A173-A177 ◽  
Author(s):  
D. J. Coster ◽  
J. R. McKinnon ◽  
J. I. McGill ◽  
B. R. Jones ◽  
F. T. Fraunfelderc
Keyword(s):  
Herpes Simplex Virus ◽  
Herpes Simplex ◽  
Clinical Evaluation ◽  
Adenine Arabinoside ◽  
Corneal Ulcers ◽  
Simplex Virus

Resistance of Herpes Simplex Virus to Adenine Arabinoside and E-5-(2-Bromovinyl)-2′-Deoxyuridine: A Physical Analysis

1982 ◽  
Vol 146 (2) ◽  
pp. 167-172 ◽  
Author(s):  
Clyde S. Crumpacker ◽  
Lowell E. Schnipper ◽  
Patricia N. Kowalsky ◽  
David M. Sherman
Keyword(s):  
Herpes Simplex Virus ◽  
Herpes Simplex ◽  
Physical Analysis ◽  
Adenine Arabinoside ◽  
Simplex Virus

scholarly journals HERPES SIMPLEX VIRUS (HSV) INFECTION IN NEONATES, TREATED WITH ADENINE ARABINOSIDE (ARA-A)

1974 ◽  
Vol 8 (4) ◽  
pp. 423-423
Author(s):  
Lawrence T Ch'ien ◽  
Richard J Whitley ◽  
Andre J Nahmias ◽  
Robert A Buchanan ◽  
Charles A Alford
Keyword(s):  
Herpes Simplex Virus ◽  
Herpes Simplex ◽  
Adenine Arabinoside ◽  
Simplex Virus

scholarly journals Diagnosis and Quantitative Detection of Herpes Simplex Virus DNA in Corneal Ulcers

2012 ◽  
Vol 8 (3) ◽  
pp. 279-284 ◽  
Author(s):  
M. Ziyaeyan ◽  
A. Alborzi ◽  
M. Jamalidous ◽  
A. Japoni ◽  
P. Badiee ◽  
...  
Keyword(s):  
Herpes Simplex Virus ◽  
Herpes Simplex ◽  
Quantitative Detection ◽  
Corneal Ulcers ◽  
Simplex Virus

Antiviral Chemotherapy and Neonatal Herpes Simplex Virus Infection: A Pilot Study—Experience With Adenine Arabinoside (ARA-A)

PEDIATRICS ◽  
1975 ◽  
Vol 55 (5) ◽  
pp. 678-685
Author(s):  
Lawrence T. Ch'ien ◽  
Richard J. Whitley ◽  
Andre J. Nahmias ◽  
Edward B. Lewin ◽  
Calvin C. Linnemann ◽  
...  
Keyword(s):  
Herpes Simplex Virus ◽  
Herpes Simplex ◽  
Neurological Deficits ◽  
Dna Viruses ◽  
Adenine Arabinoside ◽  
Study Experience ◽  
Antiviral Chemotherapy ◽  
Neonatal Herpes Simplex ◽  
Simplex Virus ◽  
Disseminated Disease

Among 13 neonates with herpes simplex virus (HSV) infection, eight had disseminated disease, one localized CNS disease, and in four the infection was confined to the skin and eyes. Ara-A, a purine nucleoside with anti-viral activity against DNA-viruses, was given (10 to 20 mg/kg/ day) by a continuous 12-hour intravenous drip for 10 to 15 days. In all, ara-A administration was begun within three to eight days after the appearance of skin vesicles which represented the hallmark of the disease. Both diagnosis and ara-A treatment were much delayed in one infant without skin vesicles and four infants whose skin vesicles appeared late, long after the occurrence of CNS damage. In this group of infants with disseminated disease, four died and one infant was left with severe neurological deficits. Eight infants (four with disseminated and four with localized skin disease) with skin vesicles as the earliest sign of infection received ara-A early, within three days after the onset of neurologic signs. All survived with no neurologic deficit at 6 months to 1 year of age. There was no apparent toxicity of ara-A to the bone marrow, liver, or kidney.

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