Association between Anti-Human Immunodeficiency Virus Type 1 (HIV-I) Antibody-Dependent Cellular Cytotoxicity Antibody Titers at Birth and Vertical Transmission of HIV-I

1994 ◽  
Vol 170 (2) ◽  
pp. 308-312 ◽  
Author(s):  
M. Jenkins ◽  
D. Landers ◽  
D. Williams-Herman ◽  
D. Wara ◽  
R. R. iscarello ◽  
...  
Keyword(s):  
Human Immunodeficiency Virus ◽  
Vertical Transmission ◽  
Human Immunodeficiency Virus Type ◽  
Virus Type ◽  
Cellular Cytotoxicity ◽  
Antibody Dependent Cellular Cytotoxicity ◽  
Immunodeficiency Virus ◽  
Vertical Transmission Of Hiv ◽  
Antibody Titers

scholarly journals Antibody-Dependent Cellular Cytotoxicity Directed against Cells Expressing Human Immunodeficiency Virus Type 1 Envelope of Primary or Laboratory-Adapted Strains by Human and Chimpanzee Monoclonal Antibodies of Different Epitope Specificities

1998 ◽  
Vol 72 (1) ◽  
pp. 286-293 ◽  
Author(s):  
Osama Alsmadi ◽  
Shermaine A. Tilley
Keyword(s):  
Human Immunodeficiency Virus ◽  
Monoclonal Antibodies ◽  
Human Immunodeficiency Virus Type ◽  
Virus Type ◽  
Cellular Cytotoxicity ◽  
Antibody Dependent Cellular Cytotoxicity ◽  
Adcc Activity ◽  
Immunodeficiency Virus ◽  
Hiv 1

ABSTRACT The characteristics of antibody-dependent cellular cytotoxicity (ADCC) directed by a panel of human and chimpanzee antienvelope (anti-Env) monoclonal antibodies (MAbs) of different epitope specificities were studied; this was accomplished by using target cells expressing human immunodeficiency virus type 1 (HIV-1) Envs of either primary or laboratory-adapted strains. Human MAbs of similar apparent affinities (1 × 109 to 2 × 109 liters/mol) against either a “cluster II”-overlapping epitope of gp41 or against the CD4 binding site, V3 loop, or C5 domain of gp120 directed substantial and comparable levels of specific lysis against targets infected with laboratory-adapted strains of HIV-1. As expected, those MAbs specific for relatively conserved regions of Env generally exhibited ADCC activity against a broader range of HIV-1 strains than those directed against variable epitopes. Significant ADCC activities of selected MAbs against primary isolate Env-expressing cells were demonstrated. In addition, a new ADCC epitope in the V2 domain of gp120 was defined. CD56+ cells were demonstrated to be the effector cells in these studies by fluorescence-activated cell sorting followed by ADCC assays. Notably, all anti-Env MAbs tested in this study, including MAbs directed against each of the known neutralization epitope clusters in gp120, directed significant levels of ADCC against targets expressing Env of one or more HIV-1 strains. These results imply that many, if not most, HIV-1-neutralizing human Abs of high affinity (≥3 × 108 liters/mol in these studies) and of the immunoglobulin G1 (IgG1) subclass (i.e., the predominate IgG subclass) are capable of directing ADCC. Since neutralizing Abs have been associated with long-term survival following HIV-1 infection, this suggests that ADCC activity may be beneficial in vivo.

scholarly journals Effect of immediate neonatal zidovudine on prevention of vertical transmission of human immunodeficiency virus type 1

2000 ◽  
Vol 4 (3) ◽  
pp. 148-152 ◽  
Author(s):  
Sayomporn Sirinavin ◽  
Winit Phaupradit ◽  
Surasak Taneepanichskul ◽  
Kalayanee Atamasirikul ◽  
Priyasuda Hetrakul ◽  
...  
Keyword(s):  
Human Immunodeficiency Virus ◽  
Vertical Transmission ◽  
Human Immunodeficiency Virus Type ◽  
Virus Type ◽  
Immunodeficiency Virus

scholarly journals Macrophage-tropic variants initiate human immunodeficiency virus type 1 infection after sexual, parenteral, and vertical transmission.

1994 ◽  
Vol 94 (5) ◽  
pp. 2060-2067 ◽  
Author(s):  
A B van't Wout ◽  
N A Kootstra ◽  
G A Mulder-Kampinga ◽  
N Albrecht-van Lent ◽  
H J Scherpbier ◽  
...  
Keyword(s):  
Human Immunodeficiency Virus ◽  
Vertical Transmission ◽  
Human Immunodeficiency Virus Type ◽  
Virus Type ◽  
Immunodeficiency Virus
Sign in / Sign up

Export Citation Format

Share Document