scholarly journals Acquired tolerance for minor histocompatibility antigens after HLA identical bone marrow transplantation

1992 ◽  
Vol 4 (1) ◽  
pp. 53-57 ◽  
Author(s):  
Marleen de Bueger ◽  
Astrid Bakker ◽  
Els Goulmy
Keyword(s):  
Bone Marrow ◽  
Bone Marrow Transplantation ◽  
Marrow Transplantation ◽  
Histocompatibility Antigens ◽  
Minor Histocompatibility Antigens

scholarly journals Recurrence of aplastic anemia following cyclophosphamide and syngeneic bone marrow transplantation: evidence for two mechanisms of graft failure

Blood ◽  
1985 ◽  
Vol 65 (3) ◽  
pp. 553-556 ◽  
Author(s):  
FR Appelbaum ◽  
MA Cheever ◽  
A Fefer ◽  
R Storb ◽  
ED Thomas
Keyword(s):  
Bone Marrow ◽  
Bone Marrow Transplantation ◽  
Aplastic Anemia ◽  
Marrow Transplantation ◽  
Graft Failure ◽  
Host Cells ◽  
High Dose ◽  
Immunological Reactivity ◽  
Histocompatibility Antigens ◽  
Minor Histocompatibility Antigens

Abstract Two patients with aplastic anemia were treated with high-dose cyclophosphamide and marrow transplantation from their normal, genetically identical twin. Both patients rapidly recovered normal marrow function, but marrow failure recurred 13 and 18 months later. Because donor and host pairs were identical twins, these cases of graft failure could not have resulted from the usual cause of graft failure, ie, immunological reactivity of host cells against unshared minor histocompatibility antigens of the donor. These results imply that there are at least two mechanisms responsible for graft failure after marrow transplantation for severe aplastic anemia.

scholarly journals Recurrence of aplastic anemia following cyclophosphamide and syngeneic bone marrow transplantation: evidence for two mechanisms of graft failure

Blood ◽  
1985 ◽  
Vol 65 (3) ◽  
pp. 553-556
Author(s):  
FR Appelbaum ◽  
MA Cheever ◽  
A Fefer ◽  
R Storb ◽  
ED Thomas
Keyword(s):  
Bone Marrow ◽  
Bone Marrow Transplantation ◽  
Aplastic Anemia ◽  
Marrow Transplantation ◽  
Graft Failure ◽  
Host Cells ◽  
High Dose ◽  
Immunological Reactivity ◽  
Histocompatibility Antigens ◽  
Minor Histocompatibility Antigens

Two patients with aplastic anemia were treated with high-dose cyclophosphamide and marrow transplantation from their normal, genetically identical twin. Both patients rapidly recovered normal marrow function, but marrow failure recurred 13 and 18 months later. Because donor and host pairs were identical twins, these cases of graft failure could not have resulted from the usual cause of graft failure, ie, immunological reactivity of host cells against unshared minor histocompatibility antigens of the donor. These results imply that there are at least two mechanisms responsible for graft failure after marrow transplantation for severe aplastic anemia.

Minor histocompatibility antigens HA-1 and HPA-5 polymorphism in HLA identical related bone marrow transplantation

2003 ◽  
Vol 64 (10) ◽  
pp. S57
Author(s):  
Maria Spyropoulou-Vlachou ◽  
Valia Kotzampasaki ◽  
Miltiadis Papadimitropoulos ◽  
Catherine Stavropoulos-Giokas
Keyword(s):  
Bone Marrow ◽  
Bone Marrow Transplantation ◽  
Marrow Transplantation ◽  
Histocompatibility Antigens ◽  
Minor Histocompatibility Antigens ◽  
Related Bone Marrow

scholarly journals Successful use of multiagent immunosuppression in the bone marrow transplantation of sensitized patients

Blood ◽  
1978 ◽  
Vol 52 (6) ◽  
pp. 1163-1169 ◽  
Author(s):  
R Parkman ◽  
J Rappeport ◽  
B Camitta ◽  
RH Levey ◽  
DG Nathan
Keyword(s):  
Bone Marrow ◽  
Bone Marrow Transplantation ◽  
Aplastic Anemia ◽  
Bone Marrow Transplant ◽  
Marrow Transplantation ◽  
Marrow Transplant ◽  
Severe Aplastic Anemia ◽  
Transplant Recipients ◽  
Histocompatibility Antigens

Abstract Of 23 patients with severe aplastic anemia, 17 were sensitized to histocompatibility antigens of HLA-A, -B, and -D loci-identical potential sibling donors as determined by cell-mediated lysis (CML) assays in vitro. Antibody-dependent sensitization was detected in 3 patients, antibody-independent cellular sensitization in 11, and both in 3. Fourteen sensitized patients were transplanted after initial multiagent immunosuppression consisting of rabbit anti-human thymocyte serum, procarbazine, and cyclophosphamide, eleven with a CML-positive donor and three with a CML-negative donor. Engraftment was achieved in each of 13 patients who were evaluable, and only 2 ultimately rejected their marrow grafts, 1 with subsequent return of his own marrow function. Five patients without evidence in vitro of sensitization were transplanted after immunosuppression with cyclophosphamide alone; none of these rejected their grafts. These studies show that sensitized bone marrow transplant recipients can be successfully transplanted after optimal donor selection and multiagent immunosuppression.

scholarly journals Successful use of multiagent immunosuppression in the bone marrow transplantation of sensitized patients

Blood ◽  
1978 ◽  
Vol 52 (6) ◽  
pp. 1163-1169 ◽  
Author(s):  
R Parkman ◽  
J Rappeport ◽  
B Camitta ◽  
RH Levey ◽  
DG Nathan
Keyword(s):  
Bone Marrow ◽  
Bone Marrow Transplantation ◽  
Aplastic Anemia ◽  
Bone Marrow Transplant ◽  
Marrow Transplantation ◽  
Marrow Transplant ◽  
Severe Aplastic Anemia ◽  
Transplant Recipients ◽  
Histocompatibility Antigens

Of 23 patients with severe aplastic anemia, 17 were sensitized to histocompatibility antigens of HLA-A, -B, and -D loci-identical potential sibling donors as determined by cell-mediated lysis (CML) assays in vitro. Antibody-dependent sensitization was detected in 3 patients, antibody-independent cellular sensitization in 11, and both in 3. Fourteen sensitized patients were transplanted after initial multiagent immunosuppression consisting of rabbit anti-human thymocyte serum, procarbazine, and cyclophosphamide, eleven with a CML-positive donor and three with a CML-negative donor. Engraftment was achieved in each of 13 patients who were evaluable, and only 2 ultimately rejected their marrow grafts, 1 with subsequent return of his own marrow function. Five patients without evidence in vitro of sensitization were transplanted after immunosuppression with cyclophosphamide alone; none of these rejected their grafts. These studies show that sensitized bone marrow transplant recipients can be successfully transplanted after optimal donor selection and multiagent immunosuppression.

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