Recently, percutaneous valve replacement has emerged as an alternative treatment for stenosis of mitral, aortic, and pulmonary valves, replacing the surgical approach and providing a new perspective on transcatheter placement of cardiac valves. The conventional open heart surgery does not suit most of the cardiothoracic patient population for various reasons. Percutaneous valve replacement has started becoming the first choice for surgical replacement of the cardiac valves. Under such a scenario where good potent porcine valves made from the pericardium of pigs are being made available, the real question is designing and developing cost effective stents to bear these valves. The ones that are imported are highly expensive which cannot be afforded by some of the Indian population. This also has substantial benefits from the standpoints of health, safety, and cost. The manufacturing of a stented aortic valve is an absolutely critical job, which requires proper designs, finite element analysis, and flow dynamics studies. This paper forms the base for an eventual manufacture of stented aortic valves, giving in-depth details pertaining to design and implantation of the bioprosthesis in the aorta with flow pattern analysis postimplantation and its hemodynamic efficacy analysis. Blood flow analysis and associated hemodynamic analysis help to understand the leakage resistance of the stented valve. A valve of this kind will enable minimal invasive cardiac surgeons to perform percutaneous aortic valve replacement with ease. This would also be an economic procedure allaying the high costs that are typically involved in conventional open heart surgery. We believe that this model has great potential for helping to set up a protocol for the growing of a tissue engineered heart valve construct.
Penetration of ceftazidime into heart valves and subcutaneous and muscle tissue of patients undergoing open-heart surgery.
