Brief Communication: Detection of T-Cell Surface Antigens in a Marek's Disease Lymphoblastoid Cell Line

1975 ◽  
Vol 54 (1) ◽  
pp. 277-279 ◽  
Author(s):  
K. Nazerian ◽  
J. M. Sharma
Keyword(s):  
T Cell ◽  
Cell Surface ◽  
Cell Line ◽  
Lymphoblastoid Cell Line ◽  
Surface Antigens ◽  
Marek's Disease ◽  
Marek’S Disease ◽  
Cell Surface Antigens

scholarly journals Human T cell surface antigens bearing a structural relationship to HLA antigens.

1981 ◽  
Vol 78 (6) ◽  
pp. 3858-3862 ◽  
Author(s):  
T. Cotner ◽  
H. Mashimo ◽  
P. C. Kung ◽  
G. Goldstein ◽  
J. L. Strominger
Keyword(s):  
T Cell ◽  
Cell Surface ◽  
Hla Antigens ◽  
Surface Antigens ◽  
Structural Relationship ◽  
Cell Surface Antigens ◽  
Human T Cell

scholarly journals Genetic regulation of the antibody response to H-2Db alloantigens in mice. I. Differences in activation of helper T cells in C57BL/10 and BALB/c congenic strains.

1975 ◽  
Vol 141 (3) ◽  
pp. 573-583 ◽  
Author(s):  
D Wernet ◽  
F Lilly
Keyword(s):  
T Cell ◽  
Cell Surface ◽  
Antibody Response ◽  
Genetic Regulation ◽  
Surface Antigens ◽  
T Helper ◽  
Spleen Cells ◽  
Igg Antibody ◽  
Cell Surface Antigens ◽  
Helper Function

B10.A(5R) mice immunized with C57BL/10 spleen cells demonstrate a normal T-cell-mediated cytotoxicity to H-2Db tumor cells but they do not mount any IgG antibody response to H-2Db alloantigens. B10.A(5R) mice do show a high titered IgG response when immunized with A.BY cells, which differ at H-2Db plus non-H-2 cell surface antigens, or with B10.A(2R) cells, which differ at H-2Db, H-2Kk, and H-2Ik cell surface antigens. These findings indicate a failure of the T-helper cells to induce the switch from IgM to IgG when the H-2Db alloantigens are the only difference on the immunizing cell. In immunizing H-2d mice with congenic H-g2 cells which differ only in the H-2Db region, mice of the C57BL/10 background made only IgM antibodies whereas mice of the BALB/c background made IgG antibodies. This comparison confirms that genes separate from H-2 regulate the T-cell helper function. The genes that influence the T-cell helper function do not regulate the T-cell-mediated cytotoxicity.

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