scholarly journals Use of Multiple Photosensitizers and Wavelengths During Photodynamic Therapy: A New Approach To Enhance Tumor Eradication

1990 ◽  
Vol 82 (10) ◽  
pp. 868-873 ◽  
Author(s):  
J. S. Nelson ◽  
L.-H. L. Liaw ◽  
R. A. Lahlum ◽  
P. L. Cooper ◽  
M. W. Berns
Keyword(s):  
Photodynamic Therapy ◽  
New Approach ◽  
Tumor Eradication

scholarly journals Photodynamic therapy: Promotion of efficacy by a sequential protocol

2016 ◽  
Vol 20 (01n04) ◽  
pp. 302-306 ◽  
Author(s):  
David Kessel
Keyword(s):  
Photodynamic Therapy ◽  
Tumor Vasculature ◽  
Therapeutic Effects ◽  
Current Development ◽  
Apoptotic Response ◽  
New Approach ◽  
Tumor Cell Destruction ◽  
Photosensitizing Agent ◽  
Tumor Eradication ◽  
Stimulation Of

Photodynamic therapy (PDT) offers a new approach to selective tumor eradication. Modifications designed to increase and optimize efficacy continue to emerge. Selective photodamage to malignant cells and their environment can bring about tumor cell destruction, shutdown of the tumor vasculature, stimulation of immunologic anti-tumor effects and potentiation of other therapeutic effects. Current development of combination protocols may provide a better rationale for integration of PDT into clinical practice. An example described here is the ability of a sequential (two-sensitizer) PDT protocol to enhance the efficacy of photokilling. The first step involves low-level lysosomal photodamage that has been shown to promote the apoptotic response to subsequent photodynamic effects directed at mitochondria. In this report, we demonstrate the ability of Photofrin, an FDA-approved photosensitizing agent, to serve as either the first or second element of the sequential protocol.

scholarly journals Alkynyl N-BODIPYs as Reactive Intermediates for the Development of Dyes for Biophotonics

2020 ◽  
Vol 3 (1) ◽  
pp. 15
Author(s):  
César Ray ◽  
Andrés García-Sampedro ◽  
Christopher Schad ◽  
Edurne Avellanal-Zaballa ◽  
Florencio Moreno ◽  
...  
Keyword(s):  
Pancreatic Cancer ◽  
Photodynamic Therapy ◽  
Click Chemistry ◽  
Cancer Cells ◽  
Reactive Intermediates ◽  
New Approach ◽  
Pancreatic Cancer Cells ◽  
Bio Imaging

A new approach for the rapid multi-functionalization of BODIPY dyes towards biophotonics is reported. It is based on novel N-BODIPYs, through reactive intermediates with alkynyl groups to be further derivatized by click chemistry. This approach has been exemplified by the development of new dyes for cell bio-imaging, which have proven to successfully internalize into pancreatic cancer cells and accumulate in the mitochondria. The in vitro suitability for photodynamic therapy (PDT) was also analyzed and confirmed our compounds to be promising PDT candidates for the treatment of pancreatic cancer.

Antimicrobial Photodynamic Therapy: A New Approach for Oral Candidiasis?

2014 ◽  
Vol 117 (2) ◽  
pp. e121
Author(s):  
KARLA BIANCA FERNANDES DA COSTA FONTES ◽  
BARBARA FREIMANN VIEIRA ◽  
ADEMAR TAKAHAMA ◽  
REBECA DE SOUZA AZEVEDO ◽  
DANIELLE RESENDE CAMISASCA BARROSO ◽  
...  
Keyword(s):  
Photodynamic Therapy ◽  
Oral Candidiasis ◽  
Antimicrobial Photodynamic Therapy ◽  
New Approach

Antimicrobial photodynamic therapy as a new approach for the treatment of vulvovaginal candidiasis: preliminary results

2018 ◽  
Vol 33 (9) ◽  
pp. 1925-1931 ◽  
Author(s):  
Maria Eugênia Simões Onofre de Santi ◽  
Renato Araujo Prates ◽  
Cristiane Miranda França ◽  
Rúbia Garcia Lopes ◽  
Aline Silva Sousa ◽  
...  
Keyword(s):  
Photodynamic Therapy ◽  
Vulvovaginal Candidiasis ◽  
Antimicrobial Photodynamic Therapy ◽  
New Approach ◽  
Preliminary Results

Photodynamic therapy as a new approach to Trichomonas vaginalis inactivation

2018 ◽  
Vol 22 ◽  
pp. 91-95 ◽  
Author(s):  
Thaisa Helena Silva Fonseca ◽  
Marina Alacoque ◽  
Fabrício Marcus Silva Oliveira ◽  
Betânia Maria Soares ◽  
Henrique Vitor Leite ◽  
...  
Keyword(s):  
Photodynamic Therapy ◽  
Trichomonas Vaginalis ◽  
New Approach
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