scholarly journals Photodynamic therapy: Promotion of efficacy by a sequential protocol

2016 ◽  
Vol 20 (01n04) ◽  
pp. 302-306 ◽  
Author(s):  
David Kessel
Keyword(s):  
Photodynamic Therapy ◽  
Tumor Vasculature ◽  
Therapeutic Effects ◽  
Current Development ◽  
Apoptotic Response ◽  
New Approach ◽  
Tumor Cell Destruction ◽  
Photosensitizing Agent ◽  
Tumor Eradication ◽  
Stimulation Of

Photodynamic therapy (PDT) offers a new approach to selective tumor eradication. Modifications designed to increase and optimize efficacy continue to emerge. Selective photodamage to malignant cells and their environment can bring about tumor cell destruction, shutdown of the tumor vasculature, stimulation of immunologic anti-tumor effects and potentiation of other therapeutic effects. Current development of combination protocols may provide a better rationale for integration of PDT into clinical practice. An example described here is the ability of a sequential (two-sensitizer) PDT protocol to enhance the efficacy of photokilling. The first step involves low-level lysosomal photodamage that has been shown to promote the apoptotic response to subsequent photodynamic effects directed at mitochondria. In this report, we demonstrate the ability of Photofrin, an FDA-approved photosensitizing agent, to serve as either the first or second element of the sequential protocol.

scholarly journals Direct tumor damage mechanisms of photodynamic therapy.

2005 ◽  
Vol 52 (2) ◽  
pp. 339-352 ◽  
Author(s):  
Dominika Nowis ◽  
Marcin Makowski ◽  
Tomasz Stokłosa ◽  
Magdalena Legat ◽  
Tadeusz Issat ◽  
...  
Keyword(s):  
Immune Response ◽  
Photodynamic Therapy ◽  
Minimally Invasive ◽  
Tumor Cell ◽  
Tumor Vasculature ◽  
Cellular Structures ◽  
Treatment Result ◽  
Antitumor Effects ◽  
Laser Sources ◽  
Photosensitizing Agent

Photodynamic therapy (PDT) is a clinically approved and rapidly developing cancer treatment regimen. It is a minimally invasive two-stage procedure that requires administration of a photosensitizing agent followed by illumination of the tumor with visible light usually generated by laser sources. A third component of PDT is molecular oxygen which is required for the most effective antitumor effects. In the presence of the latter, light of an appropriate wavelength excites the photosensitizer thereby producing cytotoxic intermediates that damage cellular structures. PDT has been approved in many countries for the treatment of lung, esophageal, bladder, skin and head and neck cancers. The antitumor effects of this treatment result from the combination of direct tumor cell photodamage, destruction of tumor vasculature and activation of an immune response. The mechanisms of the direct photodamage of tumor cells, the signaling pathways that lead to apoptosis or survival of sublethaly damaged cells, and potential novel strategies of improving the antitumor efficacy of PDT are discussed.

scholarly journals Use of Multiple Photosensitizers and Wavelengths During Photodynamic Therapy: A New Approach To Enhance Tumor Eradication

1990 ◽  
Vol 82 (10) ◽  
pp. 868-873 ◽  
Author(s):  
J. S. Nelson ◽  
L.-H. L. Liaw ◽  
R. A. Lahlum ◽  
P. L. Cooper ◽  
M. W. Berns
Keyword(s):  
Photodynamic Therapy ◽  
New Approach ◽  
Tumor Eradication

scholarly journals Synthesis and Characterization of Polyvinylpyrrolidone-Modified ZnO Quantum Dots and Their In Vitro Photodynamic Tumor Suppressive Action

2021 ◽  
Vol 22 (15) ◽  
pp. 8106
Author(s):  
Tianming Song ◽  
Yawei Qu ◽  
Zhe Ren ◽  
Shuang Yu ◽  
Mingjian Sun ◽  
...  
Keyword(s):  
Quantum Dots ◽  
Photodynamic Therapy ◽  
Inhibitory Effect ◽  
Therapeutic Effects ◽  
In Vivo Experiments ◽  
Potential Applications ◽  
Zno Quantum Dots ◽  
Zno Qds

Despite the numerous available treatments for cancer, many patients succumb to side effects and reoccurrence. Zinc oxide (ZnO) quantum dots (QDs) are inexpensive inorganic nanomaterials with potential applications in photodynamic therapy. To verify the photoluminescence of ZnO QDs and determine their inhibitory effect on tumors, we synthesized and characterized ZnO QDs modified with polyvinylpyrrolidone. The photoluminescent properties and reactive oxygen species levels of these ZnO/PVP QDs were also measured. Finally, in vitro and in vivo experiments were performed to test their photodynamic therapeutic effects in SW480 cancer cells and female nude mice. Our results indicate that the ZnO QDs had good photoluminescence and exerted an obvious inhibitory effect on SW480 tumor cells. These findings illustrate the potential applications of ZnO QDs in the fields of photoluminescence and photodynamic therapy.

scholarly journals Alkynyl N-BODIPYs as Reactive Intermediates for the Development of Dyes for Biophotonics

2020 ◽  
Vol 3 (1) ◽  
pp. 15
Author(s):  
César Ray ◽  
Andrés García-Sampedro ◽  
Christopher Schad ◽  
Edurne Avellanal-Zaballa ◽  
Florencio Moreno ◽  
...  
Keyword(s):  
Pancreatic Cancer ◽  
Photodynamic Therapy ◽  
Click Chemistry ◽  
Cancer Cells ◽  
Reactive Intermediates ◽  
New Approach ◽  
Pancreatic Cancer Cells ◽  
Bio Imaging

A new approach for the rapid multi-functionalization of BODIPY dyes towards biophotonics is reported. It is based on novel N-BODIPYs, through reactive intermediates with alkynyl groups to be further derivatized by click chemistry. This approach has been exemplified by the development of new dyes for cell bio-imaging, which have proven to successfully internalize into pancreatic cancer cells and accumulate in the mitochondria. The in vitro suitability for photodynamic therapy (PDT) was also analyzed and confirmed our compounds to be promising PDT candidates for the treatment of pancreatic cancer.

Competitive Memory Training (COMET) for Low Self-Esteem in Patients with Personality Disorders: A Randomized Effectiveness Study

2010 ◽  
Vol 39 (1) ◽  
pp. 1-19 ◽  
Author(s):  
Kees Korrelboom ◽  
Marlies Marissen ◽  
Tanja van Assendelft
Keyword(s):  
Personality Disorders ◽  
Self Esteem ◽  
Borderline Personality ◽  
Effect Sizes ◽  
Memory Training ◽  
Therapeutic Effects ◽  
New Approach ◽  
The Moment ◽  
Mental Health Institution ◽  
Intermediate Effect

Background: Self-esteem is a major concern in the treatment of patients with personality disorders in general. In patients with borderline personality disorder, low self-esteem is associated with factors contributing to suicidal and self-injurious behaviour. At the moment there are no well-proven interventions that specifically target low self-esteem. Recently, a new approach, Competitive Memory Training or COMET, aimed at the enhancement of retrieving beneficial information from memory, appeared to be successful in addressing low self-esteem in different patient populations. Aims: To assess whether COMET for low self-esteem is also an effective intervention for patients with personality disorders. Method: 91 patients with personality disorders who were already in therapy in a regular mental health institution were randomly assigned to either 7 group sessions of COMET in addition to their regular therapy or to 7 weeks of ongoing regular therapy. These latter patients received COMET after their “7 weeks waiting period for COMET”. All patients that completed COMET were contacted 3 months later to assess whether the effects of COMET had remained stable. Results: Compared to the patients who received regular therapy only, patients in the COMET + regular therapy condition improved significantly and with large effect sizes on indices of self-esteem and depression. Significant differential improvements on measures of autonomy and social optimism were also in favour of COMET, but had small to intermediate effect sizes. The therapeutic effects of COMET remained stable after 3 months on three out of the four outcome measures. Conclusion: COMET for low self-esteem seems to be an efficacious trans-diagnostic approach that can rather easily be implemented in the treatment of patients with personality disorders.

scholarly journals Stimulation of Stress-activated Protein Kinase and p38 HOG1 Kinase in Murine Keratinocytes following Photodynamic Therapy with Benzoporphyrin Derivative

1996 ◽  
Vol 271 (43) ◽  
pp. 27107-27115 ◽  
Author(s):  
Jing-song Tao ◽  
Jasbinder S. Sanghera ◽  
Steven L. Pelech ◽  
Geraldine Wong ◽  
Julia G. Levy
Keyword(s):  
Photodynamic Therapy ◽  
Protein Kinase ◽  
Stimulation Of
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