Humidification, Nebulization, and Gas Filtering

Author(s):  
Yuan Lei

‘Humidification, Nebulization, and Gas Filtering’ describes the therapies, which, while not essential to ventilation, are frequently applied together with it. This chapter provides a comprehensive discussion of these devices, including the clinical needs for them and their operating principles, options, and common complications. It describes the composition and operating principle of active heated humidifiers. Artificial humidification brings with it the additional issue of circuit rainout, which may require that heated wires be added to the breathing circuit. The chapter includes a table for troubleshooting issues related to active humidification. Heat and moisture exchangers or HMEs, an alternative to humidifiers, are also discussed. Finally, the chapter turns to the use of in-line nebulizers or aerosol therapy. The chapter ends with a discussion of respiratory gas filtering, which, for all the benefit a bacteria filter brings, also introduce the risk of occlusion.

2002 ◽  
Vol 28 (6) ◽  
pp. 719-725 ◽  
Author(s):  
Jean-Damien Ricard ◽  
Deborah Cook ◽  
Lauren Griffith ◽  
Laurent Brochard ◽  
Didier Dreyfuss

Critical Care ◽  
2021 ◽  
Vol 25 (1) ◽  
Author(s):  
François Beloncle ◽  
Antoine Studer ◽  
Valérie Seegers ◽  
Jean-Christophe Richard ◽  
Christophe Desprez ◽  
...  

Abstract Background Differences in physiology of ARDS have been described between COVID-19 and non-COVID-19 patients. This study aimed to compare initial values and longitudinal changes in respiratory system compliance (CRS), oxygenation parameters and ventilatory ratio (VR) in patients with COVID-19 and non-COVID-19 pulmonary ARDS matched on oxygenation. Methods 135 patients with COVID-19 ARDS from two centers were included in a physiological study; 767 non-COVID-19 ARDS from a clinical trial were used for the purpose of at least 1:2 matching. A propensity-matching was based on age, severity score, oxygenation, positive end-expiratory pressure (PEEP) and pulmonary cause of ARDS and allowed to include 112 COVID-19 and 198 non-COVID pulmonary ARDS. Results The two groups were similar on initial oxygenation. COVID-19 patients had a higher body mass index, higher CRS at day 1 (median [IQR], 35 [28–44] vs 32 [26–38] ml cmH2O−1, p = 0.037). At day 1, CRS was correlated with oxygenation only in non-COVID-19 patients; 61.6% and 68.2% of COVID-19 and non-COVID-19 pulmonary ARDS were still ventilated at day 7 (p = 0.241). Oxygenation became lower in COVID-19 than in non-COVID-19 patients at days 3 and 7, while CRS became similar. VR was lower at day 1 in COVID-19 than in non-COVID-19 patients but increased from day 1 to 7 only in COVID-19 patients. VR was higher at days 1, 3 and 7 in the COVID-19 patients ventilated using heat and moisture exchangers compared to heated humidifiers. After adjustment on PaO2/FiO2, PEEP and humidification device, CRS and VR were found not different between COVID-19 and non-COVID-19 patients at day 7. Day-28 mortality did not differ between COVID-19 and non-COVID-19 patients (25.9% and 23.7%, respectively, p = 0.666). Conclusions For a similar initial oxygenation, COVID-19 ARDS initially differs from classical ARDS by a higher CRS, dissociated from oxygenation. CRS become similar for patients remaining on mechanical ventilation during the first week of evolution, but oxygenation becomes lower in COVID-19 patients. Trial registration: clinicaltrials.gov NCT04385004


1988 ◽  
Vol 69 (3A) ◽  
pp. A444-A444 ◽  
Author(s):  
F. Rosenblum ◽  
M. E. Goldberg ◽  
G. E. Larijani ◽  
R. H. Jan ◽  
R. H. Epstein ◽  
...  

CHEST Journal ◽  
1996 ◽  
Vol 110 (5) ◽  
pp. 1294-1298 ◽  
Author(s):  
Geneviève Le Bourdellès ◽  
Laurence Mier ◽  
Béatrice Fiquet ◽  
Kamel Djedaïni ◽  
Georges Saumon ◽  
...  

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