Pulmonary amyloidosis

2010 ◽  
pp. 3451-3452
Author(s):  
D.J. Hendrick
Keyword(s):  
Lung Nodules ◽  
Diffuse Infiltration ◽  
Interstitial Disease ◽  
Pulmonary Amyloidosis ◽  
Parenchymal Lung

Amyloidosis rarely affects the lungs, but when it does, primary (AL) disease usually produces benign masses of amyloid tissue in the central airways or the parenchyma, and secondary (AA) disease typically causes diffuse infiltration of alveolar walls and interstitium. Laryngotracheobronchial deposits sometimes require resection if they are causing obstruction; parenchymal lung nodules rarely need to be removed, providing their histological nature is not in doubt; the prognosis of diffuse alveolar–interstitial disease is poor....

scholarly journals A Rare Cause of Diffuse Parenchymal Lung Disease together with Granulomatous Reaction: Pulmonary Amyloidosis

2013 ◽  
Vol 2013 ◽  
pp. 1-3
Author(s):  
Zuhal Ozer Simsek ◽  
Fatma Sema Oymak ◽  
Nuri Tutar ◽  
Ozlem Canoz ◽  
Ramazan Demir
Keyword(s):  
Pulmonary Involvement ◽  
Good Survival ◽  
Al Amyloidosis ◽  
Inflammatory Disorder ◽  
Exocrine Glands ◽  
Granulomatous Reaction ◽  
Diffuse Parenchymal Lung Disease ◽  
Pulmonary Amyloidosis ◽  
Parenchymal Lung Disease ◽  
Parenchymal Lung

Amyloidosis is a heterogeneous group of disorder associated with the deposition of protein in an abnormal fibrillar form. Primary Sjögren’s syndrome (PSS) is a systemic inflammatory disorder that commonly affects the exocrine glands. The reported frequency of pulmonary involvement in PSS varies widely, ranging from 9% to 75%. Pulmonary involvement occurs in light-chain (AL) amyloidosis and is uncommon in the reactive (AA) and hereditary forms. Herein we present a case of PSS associated diffuse multinodular amyloidosis in the lung. We followed up the patient without treatment for three years. There are only minimal lung symptoms related to lung infiltration. In conclusion, pulmonary involvement in SS is an extremely rare clinical manifestation and usually has a good survival rate without treatment.

Ultrastructural diagnosis of plasmacytoma on a fine-needle aspirate

1991 ◽  
Vol 49 ◽  
pp. 102-103
Author(s):  
S. Siew ◽  
W. deMendonca-Calaca
Keyword(s):  
Mononuclear Cells ◽  
Fibrous Tissue ◽  
Needle Aspiration ◽  
Focal Lesions ◽  
Diffuse Infiltration ◽  
Fine Needle ◽  
Cytoplasmic Vacuolation ◽  
Chest Mass ◽  
Mitotic Figures ◽  
Microscopy Examination

A 36 year old man presented with a mass in the chest and multiple “hot” focal lesions were identified on bone scan. Fine needle aspiration was performed of the chest mass. Routine histology showed the presence of some bundles of dense fibrous tissue and a diffuse infiltration of mononuclear cells, which varied in size and nucleo-cytoplasmic ratio. The smaller cells had eccentric hyperchromatic nuclei. Nucleoli were noted in the larger cells. There was well marked cytoplasmic vacuolation of some of the cells. Mitosis was present. A small fragment of tissue was received for electron microscopy. Examination of 1 μm sections showed trabeculae of medium-large polygonal cells with eccentric nuclei and occasional nucleoli. Some irregularly shaped cells had well marked cytoplasmic vacuolation. Mitotic figures were present.

ProSP-B as a potential biomarker in diffuse parenchymal lung disease (DPLD)

Pneumologie ◽  
2012 ◽  
Vol 66 (06) ◽  
Author(s):  
N Kahn ◽  
A Rossler ◽  
K Hornemann ◽  
T Muley ◽  
A Warth ◽  
...  
Keyword(s):  
Lung Disease ◽  
Potential Biomarker ◽  
Diffuse Parenchymal Lung Disease ◽  
Parenchymal Lung Disease ◽  
Parenchymal Lung

Multi-level 3D Densenets for False-positive Reduction in Lung Nodule Detection Based on Chest Computed Tomography

2020 ◽  
Vol 16 (8) ◽  
pp. 1004-1021
Author(s):  
Xiaoqi Lu ◽  
Yu Gu ◽  
Lidong Yang ◽  
Baohua Zhang ◽  
Ying Zhao ◽  
...  
Keyword(s):  
False Positive ◽  
Contextual Information ◽  
Lung Nodule ◽  
Positive Sample ◽  
Lung Nodules ◽  
Lung Nodule Detection ◽  
Nodule Detection ◽  
Level Information ◽  
Multi Level ◽  
Cade System

Objective: False-positive nodule reduction is a crucial part of a computer-aided detection (CADe) system, which assists radiologists in accurate lung nodule detection. In this research, a novel scheme using multi-level 3D DenseNet framework is proposed to implement false-positive nodule reduction task. Methods: Multi-level 3D DenseNet models were extended to differentiate lung nodules from falsepositive nodules. First, different models were fed with 3D cubes with different sizes for encoding multi-level contextual information to meet the challenges of the large variations of lung nodules. In addition, image rotation and flipping were utilized to upsample positive samples which consisted of a positive sample set. Furthermore, the 3D DenseNets were designed to keep low-level information of nodules, as densely connected structures in DenseNet can reuse features of lung nodules and then boost feature propagation. Finally, the optimal weighted linear combination of all model scores obtained the best classification result in this research. Results: The proposed method was evaluated with LUNA16 dataset which contained 888 thin-slice CT scans. The performance was validated via 10-fold cross-validation. Both the Free-response Receiver Operating Characteristic (FROC) curve and the Competition Performance Metric (CPM) score show that the proposed scheme can achieve a satisfactory detection performance in the falsepositive reduction track of the LUNA16 challenge. Conclusion: The result shows that the proposed scheme can be significant for false-positive nodule reduction task.

scholarly journals Shape-Based Computer-Aided Detection of Lung Nodules in Thoracic CT Images

2009 ◽  
Vol 56 (7) ◽  
pp. 1810-1820 ◽  
Author(s):  
Xujiong Ye ◽  
Xinyu Lin ◽  
J. Dehmeshki ◽  
G. Slabaugh ◽  
G. Beddoe
Keyword(s):  
Ct Images ◽  
Lung Nodules ◽  
Computer Aided Detection ◽  
Thoracic Ct ◽  
Computer Aided
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