Central neuropathic pain

2010 ◽  
pp. 57-64
Author(s):  
David Bowsher
Keyword(s):  
Multiple Sclerosis ◽  
Spinal Cord ◽  
Spinal Cord Injury ◽  
Neuropathic Pain ◽  
Central Neuropathic Pain ◽  
Cord Injury ◽  
The Uk

Central neuropathic pain can arise following damage to spinothalamocortical pathways in the spinal cord and brain Stroke, multiple sclerosis, and spinal cord injury (trauma or disease) are the predominant causes Central neuropathic pain is wrongly considered a rarity; several tens of thousands of cases exist in the UK and it can develop up to two years after stroke...

scholarly journals The Effect of Cannabis-Based Medicine on Neuropathic Pain and Spasticity in Patients with Multiple Sclerosis and Spinal Cord Injury: Study Protocol of a National Multicenter Double-Blinded, Placebo-Controlled Trial

2021 ◽  
Vol 11 (9) ◽  
pp. 1212
Author(s):  
Julie Schjødtz Hansen ◽  
Rikke Middelhede Hansen ◽  
Thor Petersen ◽  
Stefan Gustavsen ◽  
Annette Bang Oturai ◽  
...  
Keyword(s):  
Multiple Sclerosis ◽  
Spinal Cord ◽  
Spinal Cord Injury ◽  
Neuropathic Pain ◽  
Side Effects ◽  
Rating Scale ◽  
Central Neuropathic Pain ◽  
Cord Injury ◽  
Patient Reported ◽  
Based Medicine

Disease or acquired damage to the central nervous system frequently causes disabling spasticity and central neuropathic pain (NP), both of which are frequent in multiple sclerosis (MS) and spinal cord injury (SCI). Patients with MS and SCI often request treatment with cannabis-based medicine (CBM). However, knowledge about effects, side effects, choice of active cannabinoids (Δ9-tetrahydrocannabinol (THC), cannabidiol (CBD) alone or in combination), and doses of CBM remains limited. Using a double-blind, parallel design in a national multicenter cohort, this study examines the effect of CBM on spasticity and NP. Patients are randomized to treatment with capsules containing either THC, CBD, THC and CBD, or placebo. Primary endpoints are patient-reported pain and spasticity on a numerical rating scale. Other endpoints include quality of life and sleep, depression and anxiety, and relief of pain and spasticity. Side-effects of CBM are described. In a sub-study, the pharmacodynamics (PD) and pharmacokinetics (PK) of oral capsule CBM are examined. We expect that the study will contribute to the literature by providing information on the effects and side-effects of CBD, THC, and the combination of the two for central neuropathic pain and spasticity. Furthermore, we will describe the PD/PK of THC and CBD in a patient population.

scholarly journals Transplanted Human Stem Cell-Derived Interneuron Precursors Mitigate Mouse Bladder Dysfunction and Central Neuropathic Pain after Spinal Cord Injury

2016 ◽  
Vol 19 (4) ◽  
pp. 544-557 ◽  
Author(s):  
Thomas M. Fandel ◽  
Alpa Trivedi ◽  
Cory R. Nicholas ◽  
Haoqian Zhang ◽  
Jiadong Chen ◽  
...  
Keyword(s):  
Spinal Cord ◽  
Spinal Cord Injury ◽  
Neuropathic Pain ◽  
Stem Cell ◽  
Bladder Dysfunction ◽  
Human Stem Cell ◽  
Central Neuropathic Pain ◽  
Cord Injury

Duloxetine in patients with central neuropathic pain caused by spinal cord injury or stroke: A randomized, double-blind, placebo-controlled trial

Pain ◽  
2011 ◽  
Vol 152 (2) ◽  
pp. 267-273 ◽  
Author(s):  
J. H. Vranken ◽  
M. W. Hollmann ◽  
M. H. van der Vegt ◽  
M. R. Kruis ◽  
M. Heesen ◽  
...  
Keyword(s):  
Spinal Cord ◽  
Spinal Cord Injury ◽  
Neuropathic Pain ◽  
Controlled Trial ◽  
Double Blind ◽  
Double Blind Placebo ◽  
Central Neuropathic Pain ◽  
Cord Injury

Pregabalin in central neuropathic pain associated with spinal cord injury: A placebo-controlled trial

Neurology ◽  
2006 ◽  
Vol 67 (10) ◽  
pp. 1792-1800 ◽  
Author(s):  
P. J. Siddall ◽  
M. J. Cousins ◽  
A. Otte ◽  
T. Griesing ◽  
R. Chambers ◽  
...  
Keyword(s):  
Spinal Cord ◽  
Spinal Cord Injury ◽  
Neuropathic Pain ◽  
Controlled Trial ◽  
Central Neuropathic Pain ◽  
Cord Injury
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