The crystal arthropathies

2011 ◽  
pp. 269-280
Author(s):  
Alan J. Hakim ◽  
Gavin P.R. Clunie ◽  
Inam Haq
Keyword(s):  
Uric Acid ◽  
Calcium Phosphate ◽  
Calcium Oxalate ◽  
Calcium Pyrophosphate ◽  
Calcium Pyrophosphate Dihydrate ◽  
Basic Calcium Phosphate ◽  
Uric Acid Crystal ◽  
Acid Crystal ◽  
Crystal Arthropathies ◽  
Uric Acid Nephrolithiasis

Gout and hyperuricaemia 270 Calcium pyrophosphate dihydrate disease 276 Basic calcium phosphate associated disease 279 Calcium oxalate arthritis 280 The crystal arthropathies include gout, calcium pyrophosphate deposition disease (CPPD) or pseudogout, basic calcium phosphate (BCP) associated syndromes, and calcium oxalate arthritis. • In its most general sense, gout is a group of conditions characterized by hyperuricaemia and uric acid crystal formation. These clinical conditions include arthritis, tophaceous gout, uric acid nephrolithiasis, and gouty nephropathy. In its more commonly assumed definition, gout refers to the acute inflammatory arthropathy caused by uric acid crystal deposition....

Crystal-induced musculoskeletal disease

2018 ◽  
pp. 277-292
Author(s):  
Gavin Clunie ◽  
Nick Wilkinson ◽  
Elena Nikiphorou ◽  
Deepak R. Jadon
Keyword(s):  
Calcium Phosphate ◽  
Clinical Manifestations ◽  
Calcium Pyrophosphate ◽  
Classification Criteria ◽  
Musculoskeletal Disease ◽  
Calcium Pyrophosphate Dihydrate ◽  
Basic Calcium Phosphate ◽  
Community Settings ◽  
Pyrophosphate Dihydrate ◽  
User Friendly

This chapter describes crystal-induced musculoskeletal disease, which encompasses gout, hyperuricaemia, calcium pyrophosphate dihydrate disease, basic calcium phosphate-associated disease, and calcium oxalate arthritis. Their epidemiology, aetiopathogenesis, classification criteria, presenting features, clinical manifestations, and management are discussed. Diet, lifestyle, non-pharmacological and pharmacological approaches to their management are considered. User-friendly algorithms for the management of gout and calcium pyrophosphate dihydrate disease are provided, allowing both rheumatologists and non-rheumatologists to confidently manage these diseases in clinic, ward, or community settings.

scholarly journals Uric acid crystal binding to renal inner medullary collecting duct cells in primary culture.

1990 ◽  
Vol 1 (2) ◽  
pp. 187-192
Author(s):  
R J Riese ◽  
J G Kleinman ◽  
J H Wiessner ◽  
G S Mandel ◽  
N S Mandel
Keyword(s):  
Uric Acid ◽  
Calcium Oxalate ◽  
Primary Culture ◽  
Collecting Duct ◽  
Uric Acid Crystal ◽  
Acid Crystal ◽  
Inner Medullary Collecting Duct ◽  
Duct Cells ◽  
Collecting Duct Cells ◽  
Medullary Collecting Duct

Attachment of microcrystals to cellular membranes may be an important component in the pathophysiology of urolithiasis. This study characterizes the concentration-dependent binding of uric acid crystals to rat renal inner medullary collecting duct cells in primary culture. Collecting duct cell cultures grew as monolayers with interspersed aggregates of rounded cells. Cultures were incubated with 14C-uric acid crystals, and the crystals that bound were quantitated by adherent radioactivity. Uric acid crystal adherence demonstrated concentration dependent saturation with a 1/alpha value (maximum micrograms of crystals adhering to 1 cm2 of binding area) of 645 micrograms/cm2. The beta values (fraction of cross-sectional area which bound crystals) of uric acid (mean = 0.15) and calcium oxalate monohydrate (mean = 0.13) crystals did not differ significantly. Uric acid crystal binding was inhibited by pre-bound calcium oxalate monohydrate crystals in a concentration dependent manner. These data suggest that uric acid and calcium oxalate crystals exhibit similar binding patterns to rat renal inner medullary collecting duct cells in primary culture.

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