Pectus Excavatum

Author(s):  
Edward C. Rosenow

• If you do not have a lateral CXR and examined patient through the gown, you would not know what this abnormality is if you have never seen it before • Shadow is depressed chest wall “on end” • Right heart border is not evident (arrow) because heart is pushed laterally to the left and straight left heart border mimics heart disease...

2021 ◽  
pp. 991-1000
Author(s):  
Harvey Stern

Analysis and surgical management of chest wall deformities involves understanding complex congenital and acquired conditions and well as the full spectrum of reconstructive techniques. Congenital chest wall deformity includes pectus excavatum, pectus carinatum, and Poland syndrome. In surgical correction of these conditions, timing and the understanding of the growing child is important. Traumatic chest wall deformities present a different set of challenges, especially as the context is often a very unwell patient. As cardiothoracic surgeons push the boundaries of what is possible in patients with ischaemic heart disease, iatrogenic defects are not uncommon, and repair of such defects is described. Lastly, this chapter covers surgery for the coverage of major tumour resection defects in oncological surgery.


2015 ◽  
Vol 14 (2) ◽  
pp. 79-87 ◽  
Author(s):  
Brian A. Houston ◽  
Steven Hsu ◽  
Emmanouil Tampakakis ◽  
Ryan J. Tedford

The most common disease associated with high pulmonary vascular pressures and right ventricular (RV) afterload is left heart disease (LHD). In this review, we will discuss the role right heart disease (RHD) plays in LHD progression, prognosis, and treatment. We will first discuss the current definitions employed in RHD and its epidemiology in various left heart diseases. We will next explore the pathophysiology of RV dysfunction in LHD, including a discussion of the effects and components of RV afterload and RV/left ventricular contractile interactions. Finally, we will describe the recently observed clinical implications of RV dysfunction in LHD and pertinent therapeutic considerations.


2021 ◽  
Vol 37 (1) ◽  
pp. 131-139
Author(s):  
Alexander C. Egbe ◽  
Rahul Vojjini ◽  
Mohamed Badawy ◽  
Vaibhav Jain ◽  
Crystal R. Bonnichsen ◽  
...  

PLoS ONE ◽  
2021 ◽  
Vol 16 (12) ◽  
pp. e0261753
Author(s):  
Yusuke Joki ◽  
Hakuoh Konishi ◽  
Hiroyuki Ebinuma ◽  
Kiyoshi Takasu ◽  
Tohru Minamino

Background Heart failure is a severe condition often involving pulmonary hypertension (PH). Soluble low-density lipoprotein receptor with 11 ligand-binding repeats (sLR11) has been associated with pulmonary artery hypertension. We examined whether sLR11 correlates with PH in left heart disease and can be used as a predictive marker. Method We retrospectively analyzed patients with severe mitral regurgitation who underwent right heart catheterization before surgery for valve replacement or valvuloplasty from November 2005 to October 2012 at Juntendo University. We measured sLR11 levels before right heart catheterization and analyzed correlations with pulmonary hemodynamics. We compared prognoses between a group with normal sLR11 (≤9.4 ng/ml) and a group with high sLR11 (>9.4 ng/ml). Follow-up was continued for 5 years, with end points of hospitalization due to HF and death due to cardiovascular disease. Results Among 34 patients who met the inclusion criteria, sLR11 correlated with mean pulmonary artery pressure (r = 0.54, p<0.001), transpulmonary pressure gradient (r = 0.42, p = 0.012), pulmonary vascular resistance (r = 0.36, p<0.05), and log brain natriuretic peptide (BNP). However, logBNP did not correlate with pulmonary vascular resistance (p = 0.6). Levels of sLR11 were significantly higher in the 10 patients with PH (14.4±4.3 ng/ml) than in patients without PH (9.9±3.9 ng/ml; p = 0.002). At 5 years, the event rate was higher in the high-sLR11 group than in the normal-sLR11 group. The high-sLR11 group showed 5 hospitalizations due to HF (25.0%) and 2 deaths (10.0%), whereas the normal-sLR11 group showed no hospitalizations or deaths. Analyses using receiver operating characteristic curves showed a higher area under the concentration-time curve (AUC) for sLR11 level (AUC = 0.85; 95% confidence interval (CI) = 0.72–0.98) than for BNP (AUC = 0.80, 95%CI = 0.62–0.99) in the diagnosis of PH in left heart disease. Conclusions Concentration of sLR11 is associated with severity of PH and offers a strong predictor of severe mitral regurgitation in patients after surgery.


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