scholarly journals Acceleration of Olfactory Receptor Gene Loss in Primate Evolution: Possible Link to Anatomical Change in Sensory Systems and Dietary Transition

2018 ◽  
Vol 35 (6) ◽  
pp. 1437-1450 ◽  
Author(s):  
Yoshihito Niimura ◽  
Atsushi Matsui ◽  
Kazushige Touhara
Keyword(s):  
Olfactory Receptor ◽  
Gene Loss ◽  
Receptor Gene ◽  
Primate Evolution ◽  
Sensory Systems ◽  
Olfactory Receptor Gene ◽  
Anatomical Change ◽  
Dietary Transition

Differing from diseased stage in melanoma, the olfactory receptor gene OR56A4 is expressed

2021 ◽  
Author(s):  
Bronte Morse ◽  
Kobi Decker
Keyword(s):  
Breast Cancer ◽  
Cancer Patients ◽  
Olfactory Receptor ◽  
Receptor Gene ◽  
Stage I ◽  
Stage Ii ◽  
Stage Iii ◽  
Olfactory Receptor Gene ◽  
Breast Cancer Patients ◽  
Receptor Family

We have compared the global profiles of 100 tumors in Stage I, II and III with two independently releasedmicroarray datasets in order to understand their transcriptional behaviors accompanying a progression in breastcancer (1, 2). The olfactive receptor, family 56, subfamily A, member 4 OR56A4, was discovered to have beenone of the genes with the most varied expression when comparing initial tumors in stage I, stage II, and stageIII of breast cancer patients. In the stage III tumors, OR56A4 expression in comparison to the stage I tumorswas lower.

The olfactory receptor gene superfamily: data mining, classification, and nomenclature

2000 ◽  
Vol 11 (11) ◽  
pp. 1016-1023 ◽  
Author(s):  
Gustavo Glusman ◽  
Anita Bahar ◽  
Dror Sharon ◽  
Yitzhak Pilpel ◽  
Julia White ◽  
...  
Keyword(s):  
Data Mining ◽  
Olfactory Receptor ◽  
Receptor Gene ◽  
Olfactory Receptor Gene

Genome Dynamics, Evolution, and Protein Modeling in the Olfactory Receptor Gene Superfamilya

1998 ◽  
Vol 855 (1 OLFACTION AND) ◽  
pp. 182-193 ◽  
Author(s):  
DROR SHARON ◽  
GUSTAVO GLUSMAN ◽  
YITZHAK PILPEL ◽  
SHIRLEY HORN-SABARN ◽  
DORON LANCET
Keyword(s):  
Olfactory Receptor ◽  
Receptor Gene ◽  
Protein Modeling ◽  
Olfactory Receptor Gene ◽  
Genome Dynamics

scholarly journals Canine Olfactory Receptor Gene Polymorphism and Its Relation to Odor Detection Performance by Sniffer Dogs

2008 ◽  
Vol 99 (5) ◽  
pp. 518-527 ◽  
Author(s):  
A. Lesniak ◽  
M. Walczak ◽  
T. Jezierski ◽  
M. Sacharczuk ◽  
M. Gawkowski ◽  
...  
Keyword(s):  
Gene Polymorphism ◽  
Olfactory Receptor ◽  
Receptor Gene ◽  
Detection Performance ◽  
Olfactory Receptor Gene ◽  
Odor Detection ◽  
Receptor Gene Polymorphism

scholarly journals Natural Selection on the Olfactory Receptor Gene Family in Humans and Chimpanzees

2003 ◽  
Vol 73 (3) ◽  
pp. 489-501 ◽  
Author(s):  
Yoav Gilad ◽  
Carlos D. Bustamante ◽  
Doron Lancet ◽  
Svante Pääbo
Keyword(s):  
Natural Selection ◽  
Gene Family ◽  
Olfactory Receptor ◽  
Receptor Gene ◽  
Olfactory Receptor Gene ◽  
Receptor Gene Family

scholarly journals Olfactory receptors are displayed on dog mature sperm cells.

1993 ◽  
Vol 123 (6) ◽  
pp. 1441-1452 ◽  
Author(s):  
P Vanderhaeghen ◽  
S Schurmans ◽  
G Vassart ◽  
M Parmentier
Keyword(s):  
Olfactory Receptor ◽  
Germ Line ◽  
Receptor Gene ◽  
Olfactory Receptors ◽  
Olfactory Mucosa ◽  
Mature Sperm ◽  
Sperm Cells ◽  
Olfactory Receptor Gene ◽  
Mammalian Sperm ◽  
Expression Site

Olfactory receptors constitute a huge family of structurally related G protein-coupled receptors, with up to a thousand members expected. We have shown previously that genes belonging to this family were expressed in the male germ line from both dog and human. The functional significance of this unexpected site of expression was further investigated in the present study. We demonstrate that a few dog genes representative of various subfamilies of olfactory receptors are expressed essentially in testis, with little or no expression in olfactory mucosa. Other randomly selected members of the family show the expected site of expression, restricted to the olfactory system. Antibodies were generated against the deduced amino acid sequence of the most abundantly expressed olfactory receptor gene in dog testis. The purified serum was able to detect the gene product (DTMT receptor) in late round and elongated spermatids, as well as in the cytoplasmic droplet that characterizes the maturation of dog sperm cells, and on the tail midpiece of mature spermatozoa. Western blotting further confirmed the presence of a 40-kD immunoreactive protein in the membrane of mature sperm cells. Altogether , these results demonstrate that the main expression site of a subset of the large olfactory receptor gene family is not olfactory mucosa but testis. This expression correlates with the presence of the corresponding protein during sperm cell maturation, and on mature sperm cells. The pattern of expression is consistent with a role as sensor for unidentified chemicals possibly involved in the control of mammalian sperm maturation, migration, and/or fertilization.

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