scholarly journals Differences in the nuclease sensitivity between the two alleles of the immunoglobulin kappa light chain genes in mouse liver and myeloma nuclei

1982 ◽  
Vol 10 (12) ◽  
pp. 3627-3645 ◽  
Author(s):  
Wolfgang O. Weischet ◽  
Boris O. Glotov ◽  
Hannelore Schnell ◽  
Hans G. Zachau
Keyword(s):  
Light Chain ◽  
Mouse Liver ◽  
Kappa Light Chain ◽  
Immunoglobulin Kappa ◽  
Nuclease Sensitivity

scholarly journals Cloning of immunoglobulin kappa light chain genes from mouse liver and myeloma MOPC 173

1979 ◽  
Vol 6 (10) ◽  
pp. 3213-3230 ◽  
Author(s):  
Michael Steinmetz ◽  
Hans G. Zachau ◽  
Bernard Mach
Keyword(s):  
Light Chain ◽  
Mouse Liver ◽  
Kappa Light Chain ◽  
Immunoglobulin Kappa

scholarly journals Untranslated immunoglobulin kappa light chain mRNA in a lambda light chain-producing mouse myeloma, MOPC104E.

1980 ◽  
Vol 255 (11) ◽  
pp. 5291-5295
Author(s):  
T. Kataoka ◽  
M. Ono ◽  
M. Kawakami ◽  
Y. Ikawa ◽  
M. Aida ◽  
...  
Keyword(s):  
Light Chain ◽  
Kappa Light Chain ◽  
Lambda Light Chain ◽  
Immunoglobulin Kappa ◽  
Mouse Myeloma

A Murine Monoclonal Multireactive Immunoglobulin Kappa Light Chain

1994 ◽  
Vol 39 (1) ◽  
pp. 107-110 ◽  
Author(s):  
W. MAHANA ◽  
F. JACQUEMART ◽  
M. ERMONVAL
Keyword(s):  
Light Chain ◽  
Kappa Light Chain ◽  
Immunoglobulin Kappa

Basolateral secretion of kappa light chain in the polarised epithelial cell line, Caco-2

1989 ◽  
Vol 94 (2) ◽  
pp. 327-332
Author(s):  
E.J. Hughson ◽  
D.F. Cutler ◽  
C.R. Hopkins
Keyword(s):  
Epithelial Cell ◽  
Epithelial Cells ◽  
Cell Line ◽  
Light Chain ◽  
Intracellular Trafficking ◽  
Epithelial Cell Line ◽  
Kappa Light Chain ◽  
Immunoglobulin Kappa ◽  
Selective Delivery ◽  
Secretory Products

The immunoglobulin kappa light chain is constitutively secreted in non-polarised cells. It is therefore unlikely to display any of the signals thought to be required for the selective delivery of proteins to the apical or basolateral borders of polarised epithelial cells. We have transfected the gene for the kappa light chain into a polarised epithelial cell line (Caco-2) and shown that it is secreted predominantly from the basolateral surface. Metabolically labelled endogenous secretory products show the same polarity and we conclude, therefore, that in Caco-2 cells there is a major intracellular trafficking route to the basolateral border that requires no sorting signal.

scholarly journals A complex translocation at the murine kappa light-chain locus.

1987 ◽  
Vol 7 (11) ◽  
pp. 4130-4133 ◽  
Author(s):  
M A Shapiro ◽  
M Weigert
Keyword(s):  
Light Chain ◽  
Chromosome 12 ◽  
Chromosome 15 ◽  
Chromosome 6 ◽  
Kappa Light Chain ◽  
Complex Translocation ◽  
Immunoglobulin Kappa ◽  
Complex Series ◽  
Chain Locus ◽  
Light Chain Locus

We have previously reported that a segment of DNA from a murine plasmacytoma comprises DNA from three chromosomes, the immunoglobulin kappa light-chain locus on chromosome 6, the S mu locus on chromosome 12, and a region on chromosome 15. We now report that the reciprocal product contains DNA from only the kappa locus and chromosome 15 and not from S mu. We conclude that a complex series of events, including both a transposition of DNA and a translocation between chromosomes, generated these imperfect reciprocal products.

scholarly journals The added value of immunoglobulin Kappa light chain gene (IGK) rearrangement analysis in suspected B-cell lymphomas: three illustrative cases

2012 ◽  
Vol 5 (1-2) ◽  
pp. 45-56 ◽  
Author(s):  
Paula Gameiro ◽  
Marta Sebastião ◽  
Signe Spetalen ◽  
Maria Gomes da Silva ◽  
José Cabeçadas
Keyword(s):  
B Cell ◽  
Light Chain ◽  
Added Value ◽  
Chain Gene ◽  
Kappa Light Chain ◽  
B Cell Lymphomas ◽  
Light Chain Gene ◽  
Immunoglobulin Kappa
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