Does Lithium Affect Renal Sodium Handling and Renal Haemodynamics in Normal Man?

1990 ◽  
Vol 5 (12) ◽  
pp. 1007-1012 ◽  
Author(s):  
T. Hannedouche ◽  
S. Natov ◽  
A. Ikeni ◽  
F. Schmitt ◽  
B. Lacour ◽  
...  
Keyword(s):  
Renal Haemodynamics ◽  
Normal Man ◽  
Renal Sodium Handling ◽  
Sodium Handling

Effects of insulin and lipid emulsion on renal haemodynamics and renal sodium handling in IDDM patients

Diabetologia ◽  
1996 ◽  
Vol 39 (9) ◽  
pp. 1074-1082 ◽  
Author(s):  
T. Pelikánová ◽  
I. Smrčková ◽  
J. KŘíŽová ◽  
J. StŘíbrná ◽  
V. Lánská
Keyword(s):  
Lipid Emulsion ◽  
Renal Haemodynamics ◽  
Renal Sodium Handling ◽  
Sodium Handling

Relationship between Urinary Kallikrein and Renal Sodium Handling during Water Immersion in Normal Man*

1980 ◽  
Vol 50 (1) ◽  
pp. 122-127 ◽  
Author(s):  
MURRAY EPSTEIN ◽  
RICHARD A. STONE ◽  
ARTHUR G. DENUNZIO ◽  
RONALD P. FRIGON
Keyword(s):  
Water Immersion ◽  
Urinary Kallikrein ◽  
Normal Man ◽  
Renal Sodium Handling ◽  
Sodium Handling

Effects of insulin and lipid emulsion on renal haemodynamics and renal sodium handling in IDDM patients

Diabetologia ◽  
1996 ◽  
Vol 39 (9) ◽  
pp. 1074-1082 ◽  
Author(s):  
T. Pelik�nov� ◽  
I. Smrckov� ◽  
J. Kr�?ov� ◽  
J. Str�brn� ◽  
V. L�nsk�
Keyword(s):  
Lipid Emulsion ◽  
Renal Haemodynamics ◽  
Renal Sodium Handling ◽  
Sodium Handling

scholarly journals Relationship between renal prostaglandin E and renal sodium handling during water immersion in normal man.

1979 ◽  
Vol 45 (1) ◽  
pp. 71-80 ◽  
Author(s):  
M Epstein ◽  
M D Lifschitz ◽  
D S Hoffman ◽  
J H Stein
Keyword(s):  
Water Immersion ◽  
Prostaglandin E ◽  
Normal Man ◽  
Renal Sodium Handling ◽  
Sodium Handling

Renal sodium handling in acute and chronic salt loading/depletion protocols

2000 ◽  
Vol 18 (11) ◽  
pp. 1657-1664 ◽  
Author(s):  
Michel Burnier ◽  
Marie-Laure Monod ◽  
Arnaud Chioléro ◽  
Marc Maillard ◽  
Jurg Nussberger ◽  
...  
Keyword(s):  
Salt Loading ◽  
Renal Sodium Handling ◽  
Sodium Handling

Renal Sodium Handling in Relation to Environmental and Genetic Factors in Untreated Chinese

2020 ◽  
Author(s):  
Yuan-Yuan Kang ◽  
Yi-Bang Cheng ◽  
Qian-Hui Guo ◽  
Chang-Sheng Sheng ◽  
Qi-Fang Huang ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Multiple Testing ◽  
Genetic Factors ◽  
Blood Pressure Monitoring ◽  
Lithium Concentration ◽  
Tubular Dysfunction ◽  
Renal Tubular Dysfunction ◽  
Renal Sodium Handling ◽  
Renal Tubular ◽  
Sodium Handling

Abstract Background We investigated proximal and distal renal tubular sodium handling, as assessed by fractional excretion of lithium (FELi) and fractional distal reabsorption rate of sodium (FDRNa), in relation to environmental and genetic factors in untreated patients. Methods Our study participants were suspected hypertensive patients being off antihypertensive medication for ≥2 weeks and referred for 24-hour ambulatory blood pressure monitoring. We collected serum and 24-hour urine for measurement of sodium, creatinine and lithium concentration, and calculated FELi and FDRNa. We genotyped 19 SNPs associated with renal sodium handling or blood pressure using the ABI SNapShot method. Results The 1409 participants (664 men, 47.1%) had a mean (±SD) age of 51.0±10.5 years. After adjustment for host factors, both FELi and FDRNa were significantly (P≤0.01) associated with season and humidity, explaining ~1.3% and ~3.5% of the variance, respectively. FELi was highest in autumn and lowest in summer and intermediate in spring and winter (P=0.007). FDRNa was also highest in autumn but lowest in winter and intermediate in spring and summer (P<0.001). Neither FELi nor FDRNa was associated with outdoor temperature or atmospheric pressure (P≥0.13). After adjustment for host and environmental factors and Bonferroni multiple testing, among the 19 studied genetic variants, only rs12513375 was significantly associated with FELi and FDRNa (P≤0.004) and explained about 1.7% of the variance. Conclusions Renal sodium handling as measured by endogenous lithium clearance was sensitive to major environmental and genetic factors. Our finding is towards the use of these indexes for the definition of renal tubular dysfunction.

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