Relationship between renal prostaglandin E and renal sodium handling during water immersion in normal man.

1. It has been suggested that endogenous renal prostaglandin E (PGE) constitutes a determinant of renal haemodynamics and renal sodium handling in patients with cirrhosis. We have accordingly assessed the effects of augmenting endogenous prostaglandins on renal function. We utilized water immersion to the neck since previous studies demonstrated that the redistribution of blood volume and concomitant central hypervolaemia thus induced produces a prompt and marked augmentation of PGE excretion in normal man. 2. Thirteen cirrhotic patients were studied twice while in balance on a daily 10 mmol of sodium/100 mmol of potassium diet during control and during water immersion. Urinary PGE was determined hourly for 6 h. 3. Cirrhotic patients manifested a wide continuum of responses characterized by either a sluggish or barely discernible natriuretic response (n = 5) or an appropriate natriuretic response (n = 8). 4. Water immersion to the neck resulted in a highly significant increase in mean UPGEV, which was threefold that manifested by normal subjects studied under identical conditions. Furthermore, cumulative sodium excretion during immersion correlated with PGE excretion (P < 0·05). 5. These findings, together with the results of studies utilizing prostaglandin synthase inhibitors, are consistent with the postulate that renal PGE may play a role in the alterations of renal function in decompensated cirrhosis.

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Dissociation of Renin-Aldosterone and Renal Prostaglandin E during Volume Expansion Induced by Immersion in Normal Man

Clinical Science ◽

10.1042/cs0590055 ◽

1980 ◽

Vol 59 (1) ◽

pp. 55-62 ◽

Cited By ~ 3

Author(s):

M. Epstein ◽

M. D. Lifschitz ◽

R. Re ◽

E. Haber

Keyword(s):

Plasma Renin Activity ◽

Volume Expansion ◽

Water Immersion ◽

Plasma Renin ◽

Normal Subjects ◽

Plasma Aldosterone ◽

Renin Activity ◽

Prostaglandin E ◽

Plasma Aldosterone Concentration ◽

Normal Man

1. The relationship of the renin-angiotensin-aldosterone axis with renal prostaglandin E is complex. Although studies have suggested that these two hormonal systems respond to experimental manipulations in a parallel manner, their interdependence has not been assessed fully during volume expansion. Since studies have demonstrated that in normal man the central hypervolaemia induced by water immersion to the neck produces a prompt and profound suppression of plasma renin activity and plasma aldosterone concentration without concomitant alteration of plasma composition, immersion afforded a unique opportunity to assess simultaneously the effects of central hypervolaemia on plasma renin activity, plasma aldosterone concentration and prostaglandin E excretion. 2. Seven normal subjects were studied twice while in balance on a diet containing 10 mmol of sodium/day, 100 mmol of potassium/day: with indomethacin administration (50 mg given every 6 h for five doses) and without indomethacin. Urinary prostaglandin E excretion was measured hourly and plasma renin activity and plasma aldosterone concentration at 30 min intervals. 3. Immersion was associated with a marked suppression of plasma renin activity (59 ± 7%) and plasma aldosterone concentration (55 ± 3%) with a return to pre-study values during the recovery hour. Concomitantly, urinary prostaglandin E excretion increased from 4.7 to a peak of 10.9 ng/min. Although administration of indomethacin lowered the basal rate of urinary prostaglandin E excretion and plasma renin activity, it did not prevent the subsequent augmentation of urinary prostaglandin E or the suppression of plasma renin activity and plasma aldosterone during the subsequent 4 h of immersion. 4. These results demonstrate a dissociation of renin-aldosterone and prostaglandin E during hypervolaemia and suggest that whereas prostaglandin E may constitute one of the major determinants of renin release clinically and experimentally, these two hormonal systems can be dissociated from each other in response to central volume expansion in man.

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Does Lithium Affect Renal Sodium Handling and Renal Haemodynamics in Normal Man?

Nephrology Dialysis Transplantation ◽

10.1093/ndt/5.12.1007 ◽

1990 ◽

Vol 5 (12) ◽

pp. 1007-1012 ◽

Cited By ~ 2

Author(s):

T. Hannedouche ◽

S. Natov ◽

A. Ikeni ◽

F. Schmitt ◽

B. Lacour ◽

...

Keyword(s):

Renal Haemodynamics ◽

Normal Man ◽

Renal Sodium Handling ◽

Sodium Handling

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Renal sodium handling and neurohumoral systems in patients with cirrhosis in sitting posture: effects of spironolactone and water immersion

The Clinical Investigator ◽

10.1007/bf00185599 ◽

1993 ◽

Vol 71 (11) ◽

Author(s):

A.L. Gerbest ◽

A. Pilzt ◽

H. Wernze ◽

D. J�ngst

Keyword(s):

Water Immersion ◽

Sitting Posture ◽

Renal Sodium Handling ◽

Sodium Handling

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Faculty Opinions recommendation of FGF23 regulates renal sodium handling and blood pressure.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.718376319.793499116 ◽

2014 ◽

Author(s):

Christie Thomas

Keyword(s):

Blood Pressure ◽

Renal Sodium Handling ◽

Sodium Handling

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Renal sodium handling in acute and chronic salt loading/depletion protocols

Journal of Hypertension ◽

10.1097/00004872-200018110-00018 ◽

2000 ◽

Vol 18 (11) ◽

pp. 1657-1664 ◽

Cited By ~ 23

Author(s):

Michel Burnier ◽

Marie-Laure Monod ◽

Arnaud Chioléro ◽

Marc Maillard ◽

Jurg Nussberger ◽

...

Keyword(s):

Salt Loading ◽

Renal Sodium Handling ◽

Sodium Handling

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Renal Sodium Handling in Relation to Environmental and Genetic Factors in Untreated Chinese

American Journal of Hypertension ◽

10.1093/ajh/hpaa160 ◽

2020 ◽

Author(s):

Yuan-Yuan Kang ◽

Yi-Bang Cheng ◽

Qian-Hui Guo ◽

Chang-Sheng Sheng ◽

Qi-Fang Huang ◽

...

Keyword(s):

Blood Pressure ◽

Multiple Testing ◽

Genetic Factors ◽

Blood Pressure Monitoring ◽

Lithium Concentration ◽

Tubular Dysfunction ◽

Renal Tubular Dysfunction ◽

Renal Sodium Handling ◽

Renal Tubular ◽

Sodium Handling

Abstract Background We investigated proximal and distal renal tubular sodium handling, as assessed by fractional excretion of lithium (FELi) and fractional distal reabsorption rate of sodium (FDRNa), in relation to environmental and genetic factors in untreated patients. Methods Our study participants were suspected hypertensive patients being off antihypertensive medication for ≥2 weeks and referred for 24-hour ambulatory blood pressure monitoring. We collected serum and 24-hour urine for measurement of sodium, creatinine and lithium concentration, and calculated FELi and FDRNa. We genotyped 19 SNPs associated with renal sodium handling or blood pressure using the ABI SNapShot method. Results The 1409 participants (664 men, 47.1%) had a mean (±SD) age of 51.0±10.5 years. After adjustment for host factors, both FELi and FDRNa were significantly (P≤0.01) associated with season and humidity, explaining ~1.3% and ~3.5% of the variance, respectively. FELi was highest in autumn and lowest in summer and intermediate in spring and winter (P=0.007). FDRNa was also highest in autumn but lowest in winter and intermediate in spring and summer (P<0.001). Neither FELi nor FDRNa was associated with outdoor temperature or atmospheric pressure (P≥0.13). After adjustment for host and environmental factors and Bonferroni multiple testing, among the 19 studied genetic variants, only rs12513375 was significantly associated with FELi and FDRNa (P≤0.004) and explained about 1.7% of the variance. Conclusions Renal sodium handling as measured by endogenous lithium clearance was sensitive to major environmental and genetic factors. Our finding is towards the use of these indexes for the definition of renal tubular dysfunction.

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