Effect of water immersion on renin-aldosterone and renal sodium handling in normal man.

Page 368: M. Epstein and T. Saruta. “Effect of water immersion on renin-aldosterone and renal handling in normal man.” Page 368: line 10, first paragraph of materials and methods, column 2, should begin: excretory rates....

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Characterization of Renal Prostaglandin E Responsiveness in Decompensated Cirrhosis: Implications for Renal Sodium Handling

Clinical Science ◽

10.1042/cs0630555 ◽

1982 ◽

Vol 63 (6) ◽

pp. 555-563 ◽

Cited By ~ 40

Author(s):

Murray Epstein ◽

Meyer Lifschitz ◽

M. Ramachandran ◽

Kenneth Rappaport

Keyword(s):

Renal Function ◽

Water Immersion ◽

Normal Subjects ◽

Decompensated Cirrhosis ◽

Prostaglandin E ◽

Prostaglandin Synthase ◽

Endogenous Prostaglandins ◽

Cirrhotic Patients ◽

Renal Sodium Handling ◽

Sodium Handling

1. It has been suggested that endogenous renal prostaglandin E (PGE) constitutes a determinant of renal haemodynamics and renal sodium handling in patients with cirrhosis. We have accordingly assessed the effects of augmenting endogenous prostaglandins on renal function. We utilized water immersion to the neck since previous studies demonstrated that the redistribution of blood volume and concomitant central hypervolaemia thus induced produces a prompt and marked augmentation of PGE excretion in normal man. 2. Thirteen cirrhotic patients were studied twice while in balance on a daily 10 mmol of sodium/100 mmol of potassium diet during control and during water immersion. Urinary PGE was determined hourly for 6 h. 3. Cirrhotic patients manifested a wide continuum of responses characterized by either a sluggish or barely discernible natriuretic response (n = 5) or an appropriate natriuretic response (n = 8). 4. Water immersion to the neck resulted in a highly significant increase in mean UPGEV, which was threefold that manifested by normal subjects studied under identical conditions. Furthermore, cumulative sodium excretion during immersion correlated with PGE excretion (P < 0·05). 5. These findings, together with the results of studies utilizing prostaglandin synthase inhibitors, are consistent with the postulate that renal PGE may play a role in the alterations of renal function in decompensated cirrhosis.

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Faculty Opinions recommendation of FGF23 regulates renal sodium handling and blood pressure.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.718376319.793499116 ◽

2014 ◽

Author(s):

Christie Thomas

Keyword(s):

Blood Pressure ◽

Renal Sodium Handling ◽

Sodium Handling

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Effect of Water Ingress on the Mechanical and Chemical Properties of Polybutylene Terephthalate Reinforced with Glass Fibers

Materials ◽

10.3390/ma14051261 ◽

2021 ◽

Vol 14 (5) ◽

pp. 1261

Author(s):

Catarina S. P. Borges ◽

Alireza Akhavan-Safar ◽

Eduardo A. S. Marques ◽

Ricardo J. C. Carbas ◽

Christoph Ueffing ◽

...

Keyword(s):

Mechanical Properties ◽

Water Absorption ◽

Water Uptake ◽

Significant Influence ◽

Water Immersion ◽

Water Diffusion ◽

Polybutylene Terephthalate ◽

Chemical Changes ◽

Water Ingress ◽

Effect Of Water

Short fiber reinforced polymers are widely used in the construction of electronic housings, where they are often exposed to harsh environmental conditions. The main purpose of this work is the in-depth study and characterization of the water uptake behavior of PBT-GF30 (polybutylene terephthalate with 30% of short glass fiber)as well as its consequent effect on the mechanical properties of the material. Further analysis was conducted to determine at which temperature range PBT-GF30 starts experiencing chemical changes. The influence of testing procedures and conditions on the evaluation of these effects was analyzed, also drawing comparisons with previous studies. The water absorption behavior was studied through gravimetric tests at 35, 70, and 130 °C. Fiber-free PBT was also studied at 35 °C for comparison purposes. The effect of water and temperature on the mechanical properties was analyzed through bulk tensile tests. The material was tested for the three temperatures in the as-supplied state (without drying or aging). Afterwards, PBT-GF30 was tested at room temperature following water immersion at the three temperatures. Chemical changes in the material were also analyzed through Fourier-transform infrared spectroscopy (FTIR). It was concluded that the water diffusion behavior is Fickian and that PBT absorbs more water than PBT-GF30 but at a slightly higher rate. However, temperature was found to have a more significant influence on the rate of water diffusion of PBT-GF30 than fiber content did. Temperature has a significant influence on the mechanical properties of the material. Humidity contributes to a slight drop in stiffness and strength, not showing a clear dependence on water uptake. This decrease in mechanical properties occurs due to the relaxation of the polymeric chain promoted by water ingress. Between 80 and 85 °C, after water immersion, the FTIR profile of the material changes, which suggests chemical changes in the PBT. The water absorption was simulated through heat transfer analogy with good results. From the developed numerical simulation, the minimum plate size to maintain the water ingress unidirectional was 30 mm, which was validated experimentally.

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Renal sodium handling in acute and chronic salt loading/depletion protocols

Journal of Hypertension ◽

10.1097/00004872-200018110-00018 ◽

2000 ◽

Vol 18 (11) ◽

pp. 1657-1664 ◽

Cited By ~ 23

Author(s):

Michel Burnier ◽

Marie-Laure Monod ◽

Arnaud Chioléro ◽

Marc Maillard ◽

Jurg Nussberger ◽

...

Keyword(s):

Salt Loading ◽

Renal Sodium Handling ◽

Sodium Handling

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Renal Sodium Handling in Relation to Environmental and Genetic Factors in Untreated Chinese

American Journal of Hypertension ◽

10.1093/ajh/hpaa160 ◽

2020 ◽

Author(s):

Yuan-Yuan Kang ◽

Yi-Bang Cheng ◽

Qian-Hui Guo ◽

Chang-Sheng Sheng ◽

Qi-Fang Huang ◽

...

Keyword(s):

Blood Pressure ◽

Multiple Testing ◽

Genetic Factors ◽

Blood Pressure Monitoring ◽

Lithium Concentration ◽

Tubular Dysfunction ◽

Renal Tubular Dysfunction ◽

Renal Sodium Handling ◽

Renal Tubular ◽

Sodium Handling

Abstract Background We investigated proximal and distal renal tubular sodium handling, as assessed by fractional excretion of lithium (FELi) and fractional distal reabsorption rate of sodium (FDRNa), in relation to environmental and genetic factors in untreated patients. Methods Our study participants were suspected hypertensive patients being off antihypertensive medication for ≥2 weeks and referred for 24-hour ambulatory blood pressure monitoring. We collected serum and 24-hour urine for measurement of sodium, creatinine and lithium concentration, and calculated FELi and FDRNa. We genotyped 19 SNPs associated with renal sodium handling or blood pressure using the ABI SNapShot method. Results The 1409 participants (664 men, 47.1%) had a mean (±SD) age of 51.0±10.5 years. After adjustment for host factors, both FELi and FDRNa were significantly (P≤0.01) associated with season and humidity, explaining ~1.3% and ~3.5% of the variance, respectively. FELi was highest in autumn and lowest in summer and intermediate in spring and winter (P=0.007). FDRNa was also highest in autumn but lowest in winter and intermediate in spring and summer (P<0.001). Neither FELi nor FDRNa was associated with outdoor temperature or atmospheric pressure (P≥0.13). After adjustment for host and environmental factors and Bonferroni multiple testing, among the 19 studied genetic variants, only rs12513375 was significantly associated with FELi and FDRNa (P≤0.004) and explained about 1.7% of the variance. Conclusions Renal sodium handling as measured by endogenous lithium clearance was sensitive to major environmental and genetic factors. Our finding is towards the use of these indexes for the definition of renal tubular dysfunction.

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