scholarly journals Bioelectrical impedance can be used to predict muscle mass and hence improve estimation of glomerular filtration rate in non-diabetic patients with chronic kidney disease

2006 ◽  
Vol 21 (12) ◽  
pp. 3481-3487 ◽  
Author(s):  
J. H. Macdonald ◽  
S. M. Marcora ◽  
M. Jibani ◽  
G. Roberts ◽  
M. J. Kumwenda ◽  
...  
Keyword(s):  
Chronic Kidney Disease ◽  
Glomerular Filtration Rate ◽  
Kidney Disease ◽  
Glomerular Filtration ◽  
Muscle Mass ◽  
Filtration Rate ◽  
Bioelectrical Impedance ◽  
Diabetic Patients

Lack of effect of IGF-I on the glomerular filtration rate in non-diabetic patients with advanced chronic kidney disease

2009 ◽  
Vol 19 (3) ◽  
pp. 219-225 ◽  
Author(s):  
Ying Kuan ◽  
Joanne Surman ◽  
Jan Frystyk ◽  
A. Meguid El Nahas ◽  
Allan Flyvbjerg ◽  
...  
Keyword(s):  
Chronic Kidney Disease ◽  
Glomerular Filtration Rate ◽  
Kidney Disease ◽  
Glomerular Filtration ◽  
Filtration Rate ◽  
Diabetic Patients ◽  
Advanced Chronic Kidney Disease ◽  
Igf I

scholarly journals Estimation of Glomerular Filtration Rate and Predicting Diagnostic Accuracy of Cystatin C and Creatinine in Detection of Renal Function among Longstanding Type-2 Diabetics

2021 ◽  
Author(s):  
Ranakishor Pelluri ◽  
Kongara Srikanth ◽  
Jithendra Chimakurthy ◽  
Harika Paritala ◽  
Vijay K Yalamanchili ◽  
...  
Keyword(s):  
Chronic Kidney Disease ◽  
Glomerular Filtration Rate ◽  
Kidney Disease ◽  
Diagnostic Accuracy ◽  
Glomerular Filtration ◽  
Cystatin C ◽  
Filtration Rate ◽  
Roc Analysis ◽  
Diabetic Patients

Introduction: Estimation of Glomerular Filtration Rate (GFR) is dependent on Serum Creatinine (SCr). Though, a sudden decrease in GFR would not result in rapid rise in concentrations of SCr, as they are imprecise but it leads to the over diagnosis of Chronic Kidney Disease (CKD). Aim: To calculate GFR using Cystatin-C (Cys-C) based formulas to contrast its accuracy with SCr based formulas and to predict the diagnostic accuracy of Cys-C in patients with diabetes. Materials and Methods: A total 48 type-2 diabetic patients were diagnosed with CKD and their GFR was assessed using the Cys-C and SCr. GFR was measured and estimated using three equations (Cockcroft-Gault (CG), Modification of Diet in Renal Disease (MDRD) and Chronic Kidney Disease Epidemiology Collaboration (CDK-EPI), that are based on SCr and three equations (LeBricon, Grubb and Hoek) based on Cys-C among the 48 CKD patients. The filtration rate was measured using labelled diethylenetriaminepentaacetic acid (99mTc-DTPA) renal scan method as the standard for comparison. The Receiver Operating Characteristics (ROC) analysis was used to evaluate the diagnostic accuracy of the filtration rate. Results: A significant association was observed (p=0.0001) among both the estimates which were equivocal when compared with measured iGFR, SCr and Cys-C based GFR estimate. A greater difference of Area Under the Curve (AUC) was observed between SCr (0.765±0.07) and Cys-C (0.569±0.09) (p=0.04) in the ROC analysis at a creatinine clearance <60 mL/min/m2. conclusion: The SCr and Cys-C based formulae has equivocal performance in estimating GFR. SCr could be a better marker to estimate GFR among patients with Cr clearance <60 mL/min/m2.

scholarly journals Discordance in the diagnosis of chronic kidney disease between serum creatinine determination and glomerular filtration rate (calculated by Cockcroft-Gault) in hypertensive and / or diabetic patients in a spray of Araguari-MG

2020 ◽  
Vol 1 (6) ◽  
pp. 409-414
Author(s):  
Amanda Vieira Arruda ◽  
Gabriela Cristina de Alvarenga Araújo ◽  
Gustavo Prado Pouzas Guedes ◽  
Marilia Borges Carneiro ◽  
Samuel Ribeiro Dias
Keyword(s):  
Diabetes Mellitus ◽  
Chronic Kidney Disease ◽  
Glomerular Filtration Rate ◽  
Kidney Disease ◽  
Serum Creatinine ◽  
Glomerular Filtration ◽  
Filtration Rate ◽  
Diabetic Patients ◽  
De Medicina

A hipertensão arterial (HA) é um problema de saúde pública mundial e um dos principais fatores de risco para o desenvolvimento da doença renal crônica. A HA pode ser tanto a causa como a conseqüência de uma doença renal. A DRC pode ocorrer em mais de 75% dos hipertensos de qualquer idade (BASTOS, 2010) O Diabetes mellitus (DM) é uma condição que ocorre quando o corpo não fabrica insulina suficiente ou não consegue utilizar de forma adequada quantidades normais de insulina (hormônio que regula a quantidade de glicose no sangue).Os pacientes diabéticos apresentam risco aumentado para DRC e devem ser monitorizados frequentemente para a ocorrência da lesão renal. O acometimento renal pela DM representa a principal complicação microvascular da doença e a maior causa de insuficiência renal terminal em todo o mundo, cursando com morbidade e mortalidade elevadas. O risco de desenvolvimento de nefropatia é de cerca de 30% nos diabéticos tipo 1 e de 20% nos diabéticos tipo 2. (Junior, 2004) O DM é a principal causa de IRC em pacientes ingressando em hemodiálise (HD) nos países desenvolvidos, representando até quase 50% dos novos casos. (BURMEISTER, 2012) O presente trabalho tem por objetivo relatar as vivências no desenvolvimento do tema Metodologia Ativa por meio da utilização do Arco de Charles Maguerez em uma Unidade Básica de Saúde da Família (UBSF) do bairro Miranda em Araguari-MG, durante a disciplina Internato em Sistemas Municipais de Saúde da Unidade de Ensino do Curso de Medicina do Instituto Master de Ensino Presidente Antônio Carlos - IMEPAC. O Arco de Charles Maguerez é uma das estratégias de ensino-aprendizagem para o desenvolvimento da Problematização e partir da realidade social.  Durante o estudo e a observação da realidade local foram avaliados 487 prontuários, onde nos deparamos com 149 hipertensos, 68 diabéticos, 270 hipertensos e diabéticos. Identifica - se que não ocorreu a avaliação necessária a estes portadores já que de acordo com os protocolos oficiais de HAS e da Sociedade Brasileira de Nefrologia orientam, a investigação clínica e laboratorial anual com a dosagem da creatinina sérica e o cálculo da TFG com o uso da equação de Cockcroft-Gault. Propõe-se a investigação da não aplicabilidade dos protocolos oficiais Trata-se de um estudo transversal realizado em uma ESF de Araguari-MG. Houveram dois instrumentos de coleta, o primeiro foi a avaliação da Pressão Arterial (PA) realizada um uma reunião de Hipertensos, e o segundo deu-se com a análise do prontuário do grupo de pacientes estudado. Foi considerado como Hipertensão Arterial Sistêmica Controlada níveis menores que 140/90mmhg.

scholarly journals Soluble Fas affects erythropoiesis in vitro and acts as a potential predictor of erythropoiesis-stimulating agent therapy in patients with chronic kidney disease

2020 ◽  
Vol 318 (4) ◽  
pp. F861-F869
Author(s):  
Daniela Mendes Chiloff ◽  
Danilo Candido de Almeida ◽  
Maria A. Dalboni ◽  
Maria Eugênia Canziani ◽  
Sunil K. George ◽  
...  
Keyword(s):  
Chronic Kidney Disease ◽  
Glomerular Filtration Rate ◽  
Kidney Disease ◽  
Glomerular Filtration ◽  
Filtration Rate ◽  
Dependent Manner ◽  
Potential Predictor ◽  
Soluble Fas ◽  
Esa Therapy

Serum soluble Fas (sFas) levels are associated with erythropoietin (Epo) hyporesponsiveness in patients with chronic kidney disease (CKD). Whether sFas could predict the need for erythropoiesis-stimulating agent (ESA) usage and its influence in erythropoiesis remain unclear. We evaluated the relation between sFas and ESA therapy in patients with CKD with anemia and its effect on erythropoiesis in vitro. First, we performed a retrospective cohort study with 77 anemic patients with nondialysis CKD. We performed in vitro experiments to investigate whether sFas could interfere with the behavior of hematopoietic stem cells (HSCs). HSCs were isolated from umbilical cord blood and incubated with recombinant sFas protein in a dose-dependent manner. Serum sFas positively correlated with Epo levels ( r = 0.30, P = 0.001) but negatively with hemoglobin ( r = −0.55, P < 0.001) and glomerular filtration rate ( r = −0.58, P < 0.001) in patients with CKD at baseline. Elevated sFas serum levels (4,316 ± 897 vs. 2,776 ± 749, P < 0.001) with lower estimated glomerular filtration rate (26.2 ± 10.1 vs. 33.5 ± 14.3, P = 0.01) and reduced hemoglobin concentration (11.1 ± 0.9 vs. 12.5 ± 1.2, P < 0.001) were identified in patients who required ESA therapy compared with patients with non-ESA. Afterward, we detected that the sFas level was slight correlated with a necessity of ESA therapy in patients with nondialysis CKD and anemia. In vitro assays demonstrated that the erythroid progenitor cell frequency negatively correlated with sFas concentration ( r = −0.72, P < 0.001). There was decreased erythroid colony formation in vitro when CD34+ HSCs were incubated with a higher concentration of sFas protein (1.56 ± 0.29, 4.33 ± 0.53, P < 0.001). Our findings suggest that sFas is a potential predictor for ESA therapy in patients with nondialysis CKD and that elevated sFas could affect erythropoiesis in vitro.

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