FP831PROGNOSTIC ROLE OF SERUM PROCOLLAGEN LEVELS ON GRAFT SURVIVAL IN RENAL TRANSPLANT RECIPIENTS

Post-transplant diabetes mellitus (PTDM) is a frequent and relevant complication after renal transplantation: it affects 20–30% of renal transplant recipients and increases the risk for cardiovascular and infectious events. Thus, understanding pathogenesis of PTDM would help limiting its consequences. In this review, we analyse novel aspects of PTDM, based on studies of the last decade, such as the clinical evolution of PTDM, early and late, the reversibility rate, diagnostic criteria, risk factors, including pre-transplant metabolic syndrome and insulin resistance (IR) and the interaction between these factors and immunosuppressive medications. Also, we discuss novel pathogenic factors, in particular the role of β-cell function in an environment of IR and common pathways between pre-existing cell damage and tacrolimus-induced toxicity. The relevant role of prediabetes in the pathogenesis of PTDM and cardiovascular disease is also addressed. Finally, current evidence on PTDM treatment is discussed.

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The Impact of Aorto-iliac Calcifications on Patient and Graft Survival in Renal Transplant Recipients Using the TASCII Classification

Transplantation Journal ◽

10.1097/01.tp.0000543412.26879.a6 ◽

2018 ◽

Vol 102 ◽

pp. S553

Author(s):

A.A. Rijkse ◽

H.J.A.N. Kimenai ◽

M.A. van der Zijden ◽

J.I. Roodnat ◽

S. Ten Raa ◽

...

Keyword(s):

Renal Transplant ◽

Graft Survival ◽

Renal Transplant Recipients ◽

Transplant Recipients ◽

The Impact ◽

Patient And Graft Survival

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Evaluating The Economic Implications of Nonadherence And Antibody-Mediated Rejection In Renal Transplant Recipients: The Role of Once-Daily, Prolonged-Release Tacrolimus In The Uk Setting

Value in Health ◽

10.1016/j.jval.2015.03.1081 ◽

2015 ◽

Vol 18 (3) ◽

pp. A187 ◽

Cited By ~ 1

Author(s):

G. Muduma ◽

I.A. Odeyemi ◽

R.F. Pollock

Keyword(s):

Renal Transplant ◽

Prolonged Release ◽

Renal Transplant Recipients ◽

Transplant Recipients ◽

Economic Implications ◽

Once Daily ◽

Antibody Mediated Rejection ◽

The Uk

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MO998EARLY VERSUS LATE ACUTE GRAFT PYELONEPHRITIS: A RETROSPECTIVE ANALYSIS OF GRAFT AND PATIENT OUTCOMES

Nephrology Dialysis Transplantation ◽

10.1093/ndt/gfab111.0022 ◽

2021 ◽

Vol 36 (Supplement_1) ◽

Author(s):

Anupma Kaul ◽

Thomas Mathews

Keyword(s):

Renal Transplant ◽

Graft Survival ◽

Patient Survival ◽

Univariate Analysis ◽

Graft Loss ◽

Renal Transplant Recipients ◽

Transplant Recipients ◽

Kaplan Meier ◽

Baseline Characteristics ◽

Acute Graft

Abstract Background and Aims Acute graft pyelonephritis(AGPN) is thought to affect graft and patient survival among renal transplant recipients. Our objective was to compare these outcomes in those having early AGPN(<6 months from transplant) versus those having late AGPN(>6months from transplant) Method This retrospective study analyzed 150 patients who had AGPN over a period of 8 years from 2005 to 2013. They were divided into early AGPN group and late AGPN group. Their baseline characteristics were compared. Predictors of graft loss and mortality were compared using logistic regression analysis. Graft survival and patient survival were analyzed using Kaplan-Meyer survival plots Results A total of 150 patients with AGPN were analyzed. Of these 55.3% (n=83) had early AGPN and 44.7% (n=67) had late AGPN. These two groups were comparable regarding baseline characteristics and immunosuppression. In early AGPN group, 13.3% (n=11) patients had CMV disease during follow up compared to 3% (n=2) in late AGPN group(p<0.05). In the early AGPN group, 26.5% (n=22) had prolonged Foley’s catheterization (>5days) following transplant surgery compared to 7.5% (n=5) in late AGPN group (p<0.05). In the early AGPN group, 38.6% (n=32) had prolonged DJ stent in-situ (>2weeks) following transplant surgery compared to 19.4% (n=13) in the late AGPN group (p<0.05). Recurrent GPN was more common in the late AGPN group than the early AGPN group - 35.8% (n=24) versus 18.1% (n=15). Predictors for graft loss were assessed in patients with AGPN and the presence of renal abscess was predictive of graft loss in univariate analysis (HR-6.129, 95% CI 1.776–21.154, p-0.004). There were no significant predictors of mortality in univariate analysis. Kaplan Meier survival analysis showed decreased death censored graft survival in the early AGPN group (p-0.035). There was no Conclusion Occurrence of early AGPN had a significant impact on long term graft survival in renal transplant recipients with no significant effect on patient survival. This study underlines the paramount importance of the prevention of UTIs in renal transplant recipients.

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