MP121THE EFFECT OF CILNIDIPINE ON INTRADIALYTIC BLOOD PRESSURE IN INTRADIALYTIC HYPERTENSIVE PATIENTS: A MULTICENTER, PROSPECTIVE, RANDOMIZED, OPEN-LABEL STUDY

Background:Primary aim of this study was to evaluate the antihypertensive efficacy of the Cilnidipine and Chlorthalidone fixed dose combination in Indian hypertensive patients who are not controlled on traditionally used amlodipine and hydrochlorothiazide combination and also to evaluate the safety of this combination.Methods: A total of 70 eligible patients were enrolled in this prospective, open label study. The patients were given cilnidipine (10 mg) and chlorthalidone (12.5 mg) who had not achieved target blood pressure (140/90 mmHg) despite on amlodipine (5 mg) and hydrochlorothiazide (12.5mg) combination or are intolerant to the medication. The assessment was done at the end of 4 weeks and 8 weeks.Results: There were significant falls in the SBP (5.43±2.45 mmHg, P<0.05), and DBP (4.11±2.35 mmHg, P<0.05) at the end of 4 weeks as compared to those at the baseline. The trend was sustained at 8 weeks. No further significant fall in the SBP and DBP were noted after 4 weeks (5.43±2.45 and 5.22±2.38 mmHg at 4 weeks vs 4.11±2.35 and 4.01±2.23 mmHg at 8 weeks P=NS). The SBP target (140 mmHg) was achieved in 25 patients (35.71%). The DBP target (90 mmHg) was achieved in 18 patients (25.71%). The combined SBP and DBP target was achieved in 12 patients (17.14%). A similar fall in the SBP was observed in the subgroups which were analysed.Conclusions: The hypertensive patients who do not achieve the target blood pressures on amlodipine and hydrochlorothiazide can be switched to the cilnidipine and chlorthalidone combination. The combination is effective and well tolerated.

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A prospective observational open-label study to evaluate the effect of telmisartan on glycosylated hemoglobin and fasting plasma glucose levels in hypertensive patients with impaired fasting glycaemia

National Journal of Physiology Pharmacy and Pharmacology ◽

10.5455/njppp.2022.12.12434202105122021 ◽

2022 ◽

Vol 12 (7) ◽

pp. 1

Author(s):

Veena H ◽

Narendranath S ◽

Vinay Yeli

Keyword(s):

Plasma Glucose ◽

Fasting Plasma Glucose ◽

Glycosylated Hemoglobin ◽

Open Label ◽

Open Label Study ◽

Label Study ◽

Hypertensive Patients ◽

Impaired Fasting Glycaemia ◽

Glucose Levels ◽

Fasting Glycaemia

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A multicenter, open-label study of the efficacy and safety of telmisartan in mild to moderate hypertensive patients

Arquivos Brasileiros de Cardiologia ◽

10.1590/s0066-782x2002001300002 ◽

2002 ◽

Vol 79 (4) ◽

pp. 345-350 ◽

Cited By ~ 3

Author(s):

Frida Liane Plavnik ◽

Artur Beltrame Ribeiro

Keyword(s):

Efficacy And Safety ◽

Open Label ◽

Open Label Study ◽

Label Study ◽

Hypertensive Patients

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Evaluation of long-term efficacy and tolerability of irbesartan in elderly hypertensive patients with renal impairment in an open-label study

Current Therapeutic Research ◽

10.1016/s0011-393x(02)80027-3 ◽

2002 ◽

Vol 63 (3) ◽

pp. 201-215 ◽

Cited By ~ 2

Author(s):

Maria Leonarda De Rosa ◽

Piercarmine Cardace ◽

Massimiliano Rossi ◽

Antonio Baiano ◽

Alessandro de Cristofaro

Keyword(s):

Renal Impairment ◽

Open Label ◽

Open Label Study ◽

Label Study ◽

Hypertensive Patients ◽

Term Efficacy ◽

Elderly Hypertensive ◽

Elderly Hypertensive Patients

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Effectiveness, Safety and Obedience of Dienogest and Leuprolide Acetate in Postlaparoscopic Endometriosis Patients

Indonesian Journal of Obstetrics and Gynecology ◽

10.32771/inajog.v8i1.1110 ◽

2020 ◽

pp. 44-51

Author(s):

Joko P. Purwanto ◽

Yusuf Effendi ◽

Heriyadi Manan ◽

Theodorus

Keyword(s):

Blood Pressure ◽

Side Effects ◽

Safety Profile ◽

Pulse Frequency ◽

Leuprolide Acetate ◽

Therapeutic Effectiveness ◽

Open Label ◽

Open Label Study ◽

Label Study ◽

Vas Scores

Abstract Objective: Comparing therapeutic effectiveness, safety profile, and adherence between Dienogest and postoperative Leuprolide Acetate in women with endometriosis who underwent laparoscopy. Methods: This study was a randomized clinical trial comparing the open label study to compare the effectiveness of therapy, safety profile, and obedience between postoperative dienogest and leuprolide acetate in women with endometriosis who underwent laparoscopy. Result: From the statistical test it was found that there was effectiveness of dienogest after 4 weeks of therapy (p = 0.004), after 8 weeks of therapy (p = 0.004) and after 12 weeks of therapy (p = 0.004). In the leuprolide acetate group it was also found that there was effectiveness of administration after 4 weeks of therapy (p = 0.004), after 8 weeks of therapy (p = 0.004) and after 12 weeks of therapy (p = 0.003). There was no difference in systolic blood pressure (p = 0.481), diastolic blood pressure (p = 1,000) and pulse frequency (p = 0.125) breath frequency (p = 1,000) and temperature (p = 0.236) between patients who received dienogest and leuprolide acetate. From the statistical analysis it was found that there were no differences in side effects in patients who received dienogest and leuprolide acetate (p = 0.238). Conclusion: There was no difference in therapeutic effectiveness, and the safety profile assessed by side effects as well as obedience of postoperative Dienogest and Leuprolide Acetate in endometriosis women undergoing Laparoscopy because in both groups there was a decrease in VAS scores from week to week. Key Word: Dienogest, Leuprolide Acetate, Endometriosis, Post-Laparoscopy, Therapy Abstrak Tujuan: Membandingkan efektivitas terapi, profil keamanan, dan kepatuhan antara Dienogest dengan Leuprolid Asetat pascaoperatif pada wanita endometriosis yang menjalani Lapararoskopi. Metode: Penelitian ini merupakan uji klinik acak berpembanding dengan open label study untuk membandingkan efektivitas terapi, profil keamanan, dan kepatuhan antara dienogest dan leuprolid asetat pascaoperatif pada wanita endometriosis yang menjalani lapararoskopi. Hasil: Dari uji statistik didapatkan hasil terdapat efektivitas pemberian dienogest setelah 4 minggu terapi (p = 0,004), setelah 8 minggu terapi (p = 0,004) dan setelah 12 minggu terapi (p = 0,004). Pada kelompok leuprolid asetat juga didapatkan hasil terdapat efektivitas pemberian setelah 4 minggu terapi (p = 0,004), setelah 8 minggu terapi (p = 0,004) dan setelah 12 minggu terapi (p = 0,003). Tidak terdapat perbedaan tekanan darah sistolik (p = 0,481), tekanan darah diastolik (p = 1,000) dan frekuensi nadi (p = 0,125) frekuensi napas (p = 1,000) dan suhu (p = 0,236) antara pasien yang mendapatkan dienogest dan leuprolid asetat. Dari analisa statistik didapatkan hasil tidak terdapat perbedaan efek samping pada pasien yang mendapatkan dienogest dan leuprolid asetat (p = 0,238). Kesimpulan: Tidak terdapat perbedaan efektivitas terapi, dan profil keamanan yang dinilai dari efek samping serta kepatuhan Dienogest dan Leuprolid Asetat pascaoperatif pada wanita endometriosis yang menjalani Lapararoskopi karena pada kedua kelompok terdapat penurunan VAS skor dari minggu ke minggu.

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