P08.21 Discovery of CT-179--a small molecule inhibitor of the transcription factor OLIG2 with potent anti-tumour activity in high-grade glioma

High Grade ◽

Anti Tumour Activity ◽

Molecule Inhibitor ◽

Tumour Activity

EXTH-08. DISCOVERY OF CT-179: A SMALL MOLECULE INHIBITOR OF THE OLIG2 TRANSCRIPTION FACTOR WITH POTENT ANTI-TUMOUR ACTIVITY IN HIGH-GRADE GLIOMA

Neuro-Oncology ◽

10.1093/neuonc/nox168.304 ◽

2017 ◽

Vol 19 (suppl_6) ◽

pp. vi74-vi74

Author(s):

Terrance Johns

Keyword(s):

Transcription Factor ◽

Small Molecule ◽

High Grade Glioma ◽

High Grade ◽

Anti Tumour Activity ◽

Molecule Inhibitor ◽

Tumour Activity

RBIO-02. PERSONALIZED SCREENING OF RADIOSENSITIZATION BY A TGF-β SMALL MOLECULE INHIBITOR USING CULTURED EXPLANTS OF HIGH GRADE GLIOMA (HGG) PATIENT SPECIMENS

Neuro-Oncology ◽

10.1093/neuonc/now212.722 ◽

2016 ◽

Vol 18 (suppl_6) ◽

pp. vi172-vi173

Author(s):

Lin Ma ◽

N. Sumru Bayin ◽

Dimitris Placantonakis ◽

Mary Helen Barcellos-Hoff

Keyword(s):

Small Molecule ◽

High Grade Glioma ◽

High Grade ◽

Precision Medicine with TGF-β Inhibition Using Tumor Explants: Comment on “Patient-Specific Screening Using High-Grade Glioma Explants to Determine Potential Radiosensitization by a TGF-β Small Molecule Inhibitor” by N. Sumru Bayin et al.

Neoplasia ◽

10.1016/j.neo.2016.10.009 ◽

2016 ◽

Vol 18 (12) ◽

pp. 806-807

Author(s):

Haidong Huang ◽

Jennifer S. Yu

Keyword(s):

Precision Medicine ◽

Small Molecule ◽

High Grade Glioma ◽

Patient Specific ◽

High Grade ◽

Patient-Specific Screening Using High-Grade Glioma Explants to Determine Potential Radiosensitization by a TGF-β Small Molecule Inhibitor

Neoplasia ◽

10.1016/j.neo.2016.08.008 ◽

2016 ◽

Vol 18 (12) ◽

pp. 795-805 ◽

Cited By ~ 22

Author(s):

N. Sumru Bayin ◽

Lin Ma ◽

Cheddhi Thomas ◽

Rabaa Baitalmal ◽

Akhila Sure ◽

...

Keyword(s):

Small Molecule ◽

High Grade Glioma ◽

Patient Specific ◽

High Grade ◽

Corrigendum to: “Small Molecule Inhibitor of CBFβ-RUNX Binding for RUNX Transcription Factor Driven Cancers” [EBioMedicine 8 (2016) 117–131]

EBioMedicine ◽

10.1016/j.ebiom.2017.10.029 ◽

2017 ◽

Vol 25 ◽

pp. 188

Author(s):

Anuradha Illendula ◽

Jane Gilmour ◽

Jolanta Grembecka ◽

Venkata Sesha Srimath Tirumala ◽

Adam Boulton ◽

...

Keyword(s):

Transcription Factor ◽

Small Molecule ◽

1-Benzyl-indole-3-carbinol is a highly potent new small molecule inhibitor of Wnt/β-catenin signaling in melanoma cells that coordinately inhibits cell proliferation and disrupts expression of microphthalmia-associated transcription factor isoform-M

Carcinogenesis ◽

10.1093/carcin/bgx103 ◽

2017 ◽

Vol 38 (12) ◽

pp. 1207-1217 ◽

Cited By ~ 5

Author(s):

Aishwarya Kundu ◽

Michelle G Khouri ◽

Sheila Aryana ◽

Gary L Firestone

Keyword(s):

Cell Proliferation ◽

Transcription Factor ◽

Small Molecule ◽

Melanoma Cells ◽

Author response: R-propranolol is a small molecule inhibitor of the SOX18 transcription factor in a rare vascular syndrome and hemangioma

10.7554/elife.43026.017 ◽

2019 ◽

Cited By ~ 1

Author(s):

Jeroen Overman ◽

Frank Fontaine ◽

Jill Wylie-Sears ◽

Mehdi Moustaqil ◽

Lan Huang ◽

...

Keyword(s):

Transcription Factor ◽

Small Molecule ◽

Author Response ◽

Dasatinib, a small molecule inhibitor of the Src kinase, reduces the growth and activates apoptosis in pre-neoplastic Barrett's esophagus cell lines: Evidence for a noninvasive treatment of high-grade dysplasia

Journal of Thoracic and Cardiovascular Surgery ◽

10.1016/j.jtcvs.2012.10.041 ◽

2013 ◽

Vol 145 (2) ◽

pp. 531-538 ◽

Cited By ~ 5

Author(s):

Landon J. Inge ◽

Aaron J. Fowler ◽

Kimberly M. Paquette ◽

Amanda L. Richer ◽

Nhan Tran ◽

...

Keyword(s):

Barrett’S Esophagus ◽

Cell Lines ◽

Small Molecule ◽

Barrett's Esophagus ◽

Src Kinase ◽

High Grade Dysplasia ◽

High Grade ◽

Noninvasive Treatment ◽

Small Molecule Inhibitor of CBFβ-RUNX Binding for RUNX Transcription Factor Driven Cancers

EBioMedicine ◽

10.1016/j.ebiom.2016.04.032 ◽

2016 ◽

Vol 8 ◽

pp. 117-131 ◽

Cited By ~ 40

Author(s):

Anuradha Illendula ◽

Jane Gilmour ◽

Jolanta Grembecka ◽

Venkata Sesha Srimath Tirumala ◽

Adam Boulton ◽

...

Keyword(s):

Transcription Factor ◽

Small Molecule ◽

Disruption of NOTCH signaling by a small molecule inhibitor of the transcription factor RBPJ

Scientific Reports ◽

10.1038/s41598-019-46948-5 ◽

2019 ◽

Vol 9 (1) ◽

Cited By ~ 8

Author(s):

Cecilia Hurtado ◽

Alena Safarova ◽

Michael Smith ◽

Raeeun Chung ◽

Arne A. N. Bruyneel ◽

...

Keyword(s):

Transcription Factor ◽

Notch Signaling ◽

Small Molecule ◽