Introduction to Simulation and MCMC Methods

2011 ◽  
pp. 182-217 ◽  
Author(s):  
Siddhartha Chib
Keyword(s):  
Monte Carlo ◽  
Markov Chain ◽  
Markov Chain Monte Carlo ◽  
Marginal Likelihood ◽  
Mcmc Methods ◽  
Posterior Distributions ◽  
Extensive Discussion ◽  
Block Algorithm ◽  
Target Probability ◽  
Acceptance Condition

The purpose of this article is to provide an overview of Monte Carlo methods for generating variates from a target probability distribution that are based on Markov chains. These methods, called Markov chain Monte Carlo (MCMC) methods, are widely used to summarize complicated posterior distributions in Bayesian statistics and econometrics. This article begins with an intuitive explanation of the ideas and concepts that underlie popular algorithms such as the Metropolis-Hastings algorithm and multi-block algorithm. It provides the concept of a source or proposal density, which is used to supply a randomization step or an acceptance condition to determine if the candidate draw should be accepted. It is important to assess the performance of the sampling algorithm to determine the rate of mixing. Finally, this article offers an extensive discussion of marginal likelihood calculation using posterior simulator output.

scholarly journals Mapping-Linked Quantitative Trait Loci Using Bayesian Analysis and Markov Chain Monte Carlo Algorithms

Genetics ◽  
1997 ◽  
Vol 146 (2) ◽  
pp. 735-743 ◽  
Author(s):  
Pekka Uimari ◽  
Ina Hoeschele
Keyword(s):  
Monte Carlo ◽  
Markov Chain ◽  
Markov Chain Monte Carlo ◽  
Quantitative Trait Loci ◽  
Quantitative Trait ◽  
Allele Frequencies ◽  
Mcmc Methods ◽  
Substitution Effects ◽  
Indicator Variable ◽  
Trait Loci

A Bayesian method for mapping linked quantitative trait loci (QTL) using multiple linked genetic markers is presented. Parameter estimation and hypothesis testing was implemented via Markov chain Monte Carlo (MCMC) algorithms. Parameters included were allele frequencies and substitution effects for two biallelic QTL, map positions of the QTL and markers, allele frequencies of the markers, and polygenic and residual variances. Missing data were polygenic effects and multi-locus marker-QTL genotypes. Three different MCMC schemes for testing the presence of a single or two linked QTL on the chromosome were compared. The first approach includes a model indicator variable representing two unlinked QTL affecting the trait, one linked and one unlinked QTL, or both QTL linked with the markers. The second approach incorporates an indicator variable for each QTL into the model for phenotype, allowing or not allowing for a substitution effect of a QTL on phenotype, and the third approach is based on model determination by reversible jump MCMC. Methods were evaluated empirically by analyzing simulated granddaughter designs. All methods identified correctly a second, linked QTL and did not reject the one-QTL model when there was only a single QTL and no additional or an unlinked QTL.

scholarly journals Parallel Markov chain Monte Carlo for non-Gaussian posterior distributions

Stat ◽  
2015 ◽  
Vol 4 (1) ◽  
pp. 304-319 ◽  
Author(s):  
Alexey Miroshnikov ◽  
Zheng Wei ◽  
Erin Marie Conlon
Keyword(s):  
Monte Carlo ◽  
Markov Chain ◽  
Markov Chain Monte Carlo ◽  
Posterior Distributions ◽  
Non Gaussian

scholarly journals Bayesian Metric Multidimensional Scaling

2013 ◽  
Vol 21 (1) ◽  
pp. 125-140 ◽  
Author(s):  
Ryan Bakker ◽  
Keith T. Poole
Keyword(s):  
Monte Carlo ◽  
Markov Chain ◽  
Bayesian Methods ◽  
Optimal Solution ◽  
Full Rank ◽  
Mcmc Methods ◽  
Ratio Scale ◽  
Posterior Distributions ◽  
Point Estimates ◽  
Inflection Points

In this article, we show how to apply Bayesian methods to noisy ratio scale distances for both the classical similarities problem as well as the unfolding problem. Bayesian methods produce essentially the same point estimates as the classical methods, but are superior in that they provide more accurate measures of uncertainty in the data. Identification is nontrivial for this class of problems because a configuration of points that reproduces the distances is identified only up to a choice of origin, angles of rotation, and sign flips on the dimensions. We prove that fixing the origin and rotation is sufficient to identify a configuration in the sense that the corresponding maxima/minima are inflection points with full-rank Hessians. However, an unavoidable result is multiple posterior distributions that are mirror images of one another. This poses a problem for Markov chain Monte Carlo (MCMC) methods. The approach we take is to find the optimal solution using standard optimizers. The configuration of points from the optimizers is then used to isolate a single Bayesian posterior that can then be easily analyzed with standard MCMC methods.

scholarly journals Bayesian calibration of terrestrial ecosystem models: a study of advanced Markov chain Monte Carlo methods

2017 ◽  
Vol 14 (18) ◽  
pp. 4295-4314 ◽  
Author(s):  
Dan Lu ◽  
Daniel Ricciuto ◽  
Anthony Walker ◽  
Cosmin Safta ◽  
William Munger
Keyword(s):  
Monte Carlo ◽  
Markov Chain ◽  
Markov Chain Monte Carlo ◽  
Likelihood Function ◽  
Terrestrial Ecosystem ◽  
Error Model ◽  
Model Parameters ◽  
Posterior Distributions ◽  
Ecosystem Models ◽  
Bayesian Calibration

Abstract. Calibration of terrestrial ecosystem models is important but challenging. Bayesian inference implemented by Markov chain Monte Carlo (MCMC) sampling provides a comprehensive framework to estimate model parameters and associated uncertainties using their posterior distributions. The effectiveness and efficiency of the method strongly depend on the MCMC algorithm used. In this work, a differential evolution adaptive Metropolis (DREAM) algorithm is used to estimate posterior distributions of 21 parameters for the data assimilation linked ecosystem carbon (DALEC) model using 14 years of daily net ecosystem exchange data collected at the Harvard Forest Environmental Measurement Site eddy-flux tower. The calibration of DREAM results in a better model fit and predictive performance compared to the popular adaptive Metropolis (AM) scheme. Moreover, DREAM indicates that two parameters controlling autumn phenology have multiple modes in their posterior distributions while AM only identifies one mode. The application suggests that DREAM is very suitable to calibrate complex terrestrial ecosystem models, where the uncertain parameter size is usually large and existence of local optima is always a concern. In addition, this effort justifies the assumptions of the error model used in Bayesian calibration according to the residual analysis. The result indicates that a heteroscedastic, correlated, Gaussian error model is appropriate for the problem, and the consequent constructed likelihood function can alleviate the underestimation of parameter uncertainty that is usually caused by using uncorrelated error models.

scholarly journals A sequential Bayesian approach for the estimation of the age–depth relationship of Dome Fuji ice core

2015 ◽  
Vol 2 (3) ◽  
pp. 939-968
Author(s):  
S. Nakano ◽  
K. Suzuki ◽  
K. Kawamura ◽  
F. Parrenin ◽  
T. Higuchi
Keyword(s):  
Monte Carlo ◽  
Markov Chain ◽  
Markov Chain Monte Carlo ◽  
Sequential Monte Carlo ◽  
Ice Core ◽  
Posterior Distributions ◽  
Metropolis Method ◽  
Depth Relationship ◽  
Relationship Of ◽  
Thinning Process

Abstract. A technique for estimating the age–depth relationship in an ice core and evaluating its uncertainty is presented. The age–depth relationship is mainly determined by the accumulation of snow at the site of the ice core and the thinning process due to the horizontal stretching and vertical compression of ice layers. However, since neither the accumulation process nor the thinning process are fully understood, it is essential to incorporate observational information into a model that describes the accumulation and thinning processes. In the proposed technique, the age as a function of depth is estimated from age markers and δ18O data. The estimation is achieved using the particle Markov chain Monte Carlo (PMCMC) method, in which the sequential Monte Carlo (SMC) method is combined with the Markov chain Monte Carlo method. In this hybrid method, the posterior distributions for the parameters in the models for the accumulation and thinning processes are computed using the Metropolis method, in which the likelihood is obtained with the SMC method. Meanwhile, the posterior distribution for the age as a function of depth is obtained by collecting the samples generated by the SMC method with Metropolis iterations. The use of this PMCMC method enables us to estimate the age–depth relationship without assuming either linearity or Gaussianity. The performance of the proposed technique is demonstrated by applying it to ice core data from Dome Fuji in Antarctica.

scholarly journals Markov chain Monte Carlo inference for Markov jump processes via the linear noise approximation

2013 ◽  
Vol 371 (1984) ◽  
pp. 20110541 ◽  
Author(s):  
Vassilios Stathopoulos ◽  
Mark A. Girolami
Keyword(s):  
Monte Carlo ◽  
Markov Chain ◽  
Markov Chain Monte Carlo ◽  
Jump Processes ◽  
Mcmc Methods ◽  
Computationally Efficient ◽  
Markov Jump ◽  
Riemann Manifold ◽  
Exact Inference ◽  
Markov Jump Processes

Bayesian analysis for Markov jump processes (MJPs) is a non-trivial and challenging problem. Although exact inference is theoretically possible, it is computationally demanding, thus its applicability is limited to a small class of problems. In this paper, we describe the application of Riemann manifold Markov chain Monte Carlo (MCMC) methods using an approximation to the likelihood of the MJP that is valid when the system modelled is near its thermodynamic limit. The proposed approach is both statistically and computationally efficient whereas the convergence rate and mixing of the chains allow for fast MCMC inference. The methodology is evaluated using numerical simulations on two problems from chemical kinetics and one from systems biology.

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