Intracellular Redox State and Stimulation of Gluconeogenesis by Glucagon and Norepinephrine in the Perfused Rat Liver

1980 ◽  
Vol 87 (1) ◽  
pp. 153-166 ◽  
Author(s):  
Tsukasa SUGANO ◽  
Masakazu SHIOTA ◽  
Takashi TANAKA ◽  
Yhoichi MIYAMAE ◽  
Masakazu SHIMADA ◽  
...  
Keyword(s):  
Rat Liver ◽  
Redox State ◽  
Perfused Rat Liver ◽  
Stimulation Of ◽  
Intracellular Redox

The Metabolite Ratio as a Function of Chloral Hydrate Dose and Intracellular Redox State in the Perfused Rat Liver

1987 ◽  
Vol 60 (5) ◽  
pp. 325-329 ◽  
Author(s):  
Toshihiro Kawamoto ◽  
Tatsuya Hobara ◽  
Haruo Kobayashi ◽  
Susumu Iwamoto ◽  
Tsunemi Sakai ◽  
...  
Keyword(s):  
Rat Liver ◽  
Redox State ◽  
Chloral Hydrate ◽  
Perfused Rat Liver ◽  
Metabolite Ratio ◽  
Intracellular Redox

Nitroglycerin and isosorbide dinitrate stimulation of glutathione disulfide efflux from perfused rat liver

1989 ◽  
Vol 38 (21) ◽  
pp. 3807-3810 ◽  
Author(s):  
Kristina E. Hill ◽  
Daniel M. Ziegler ◽  
Karl-Heinz Konz ◽  
Michael Haap ◽  
Robert W. Hunt ◽  
...  
Keyword(s):  
Rat Liver ◽  
Isosorbide Dinitrate ◽  
Perfused Rat Liver ◽  
Glutathione Disulfide ◽  
Stimulation Of

Receptor-mediated stimulation of taurocholate efflux from the rat hepatocyte and the ex vivo perfused rat liver

1990 ◽  
Vol 175 (2) ◽  
pp. 117-128 ◽  
Author(s):  
Wendy F. Kuhn ◽  
Douglas M. Heuman ◽  
Z. Reno Vlahcevic ◽  
David A. Gewirtz
Keyword(s):  
Rat Liver ◽  
Ex Vivo ◽  
Perfused Rat Liver ◽  
Rat Hepatocyte ◽  
Stimulation Of

scholarly journals The Ca2+-mobilizing actions of vasopressin and angiotensin differ from those of the α-adrenergic agonist phenylephrine in the perfused rat liver

1985 ◽  
Vol 232 (3) ◽  
pp. 911-917 ◽  
Author(s):  
J G Altin ◽  
F L Bygrave
Keyword(s):  
Plasma Membrane ◽  
Rat Liver ◽  
Similar Amount ◽  
Perfused Rat Liver ◽  
Adrenergic Agonists ◽  
Adrenergic Agonist ◽  
Hormone Administration ◽  
Sensitive Electrode ◽  
Stimulation Of

A Ca2+-sensitive electrode was used to study net Ca2+-flux changes induced by the administration of phenylephrine, vasopressin and angiotensin to the perfused rat liver. The studies reveal that, although the Ca2+ responses induced by vasopressin and angiotensin are similar, they are quite different from the Ca2+ fluxes induced by phenylephrine. The administration of phenylephrine is accompanied by a stimulation of a net amount of Ca2+ efflux (140 nmol/g of liver). A re-uptake of a similar amount of Ca2+ occurs only after the hormone is removed. In contrast, the administration of vasopressin or angiotensin to livers perfused with 1.3 mM-Ca2+ induces the release of a relatively small amount of Ca2+ (approx. 40 nmol/g of liver) during the first 60 s. This is followed by a much larger amount of Ca2+ uptake (70-140 nmol/g of liver) after 1-2.5 min of hormone administration, and a slow efflux or loss of a similar amount of Ca2+ over a period of 6-8 min. At lower concentrations of perfusate Ca2+ (less than 600 microM) these hormones induce only a net efflux of the ion. These results suggest that at physiological concentrations of extracellular Ca2+ the mechanism by which alpha-adrenergic agonists mobilize cellular Ca2+ is different from that involving vasopressin and angiotensin. It seems that the hormones may have quite diverse effects on Ca2+ transport across the plasma membrane and perhaps organellar membranes in liver.

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