Purification and Some Properties of a Myofibrillar Protein-Degrading Protease, Cathepsin L, from Rabbit Skeletal Muscle1

1980 ◽  
Keyword(s):  
Skeletal Muscle ◽  
Cathepsin L ◽  
Myofibrillar Protein ◽  
Rabbit Skeletal Muscle

The immunohistochemical location of cathepsin L in rabbit skeletal muscle

1987 ◽  
Vol 86 (4) ◽  
pp. 379-383 ◽  
Author(s):  
M. A. J. Taylor ◽  
R. E. almond ◽  
D. J. Etherington
Keyword(s):  
Skeletal Muscle ◽  
Cathepsin L ◽  
Rabbit Skeletal Muscle

The ubiquitin–proteasome system and skeletal muscle wasting

2005 ◽  
Vol 41 ◽  
pp. 173-186 ◽  
Author(s):  
Didier Attaix ◽  
Sophie Ventadour ◽  
Audrey Codran ◽  
Daniel Béchet ◽  
Daniel Taillandier ◽  
...  
Keyword(s):  
Skeletal Muscle ◽  
Muscle Wasting ◽  
Proteolytic Enzymes ◽  
Cathepsin L ◽  
Ubiquitin Proteasome System ◽  
Complete Breakdown ◽  
Skeletal Muscle Proteins ◽  
Ubiquitin Proteasome ◽  
Tripeptidyl Peptidase Ii ◽  
F Box Protein

The ubiquitin–proteasome system (UPS) is believed to degrade the major contractile skeletal muscle proteins and plays a major role in muscle wasting. Different and multiple events in the ubiquitination, deubiquitination and proteolytic machineries are responsible for the activation of the system and subsequent muscle wasting. However, other proteolytic enzymes act upstream (possibly m-calpain, cathepsin L, and/or caspase 3) and downstream (tripeptidyl-peptidase II and aminopeptidases) of the UPS, for the complete breakdown of the myofibrillar proteins into free amino acids. Recent studies have identified a few critical proteins that seem necessary for muscle wasting {i.e. the MAFbx (muscle atrophy F-box protein, also called atrogin-1) and MuRF-1 [muscle-specific RING (really interesting new gene) finger 1] ubiquitin–protein ligases}. The characterization of their signalling pathways is leading to new pharmacological approaches that can be useful to block or partially prevent muscle wasting in human patients.

scholarly journals The Reduction in Vitro of 17α-Hydroxypregnenolone (3β,17α-Dihydroxy-Δ5-pregnen-20-one) by Rabbit Skeletal Muscle

1960 ◽  
Vol 235 (10) ◽  
pp. 2797-2800
Author(s):  
Patricia Z. Thomas ◽  
Enrico Forchielli ◽  
Ralph I. Dorfman
Keyword(s):  
Skeletal Muscle ◽  
Rabbit Skeletal Muscle

scholarly journals Characterization of rabbit skeletal muscle glycogenin. Tyrosine 194 is essential for function

1993 ◽  
Vol 268 (20) ◽  
pp. 14687-14693 ◽  
Author(s):  
Y. Cao ◽  
A.M. Mahrenholz ◽  
A.A. DePaoli-Roach ◽  
P.J. Roach
Keyword(s):  
Skeletal Muscle ◽  
Rabbit Skeletal Muscle
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