scholarly journals Prognosis of Hereditary Nonpolyposis Colorectal Cancer (HNPCC) and the Role of Japanese Criteria for HNPCC

1996 ◽  
Vol 26 (5) ◽  
pp. 351-355 ◽  
Author(s):  
S. Fujita ◽  
Y. Moriya ◽  
K. Sugihara ◽  
T. Akasu ◽  
K. Ushio
Keyword(s):  
Colorectal Cancer ◽  
Hereditary Nonpolyposis Colorectal Cancer ◽  
Hereditary Nonpolyposis

Hereditary Nonpolyposis Colorectal Cancer (Lynch Syndrome): Molecular Pathogenesis and Clinical Approaches to Diagnosis and Management for Nurses

2008 ◽  
Vol 9 (3) ◽  
pp. 185-199 ◽  
Author(s):  
Emma L. Kurnat-Thoma
Keyword(s):  
Colorectal Cancer ◽  
Lynch Syndrome ◽  
Hereditary Nonpolyposis Colorectal Cancer ◽  
Western Hemisphere ◽  
Diagnosis And Management ◽  
Hereditary Nonpolyposis ◽  
Clinical Detection ◽  
Hepatobiliary Tract ◽  
Risk Of Cancer

Hereditary nonpolyposis colorectal cancer (HNPCC), also referred to as Lynch syndrome, is the most common form of hereditary colorectal cancer and is responsible for 2% to 4% of all colorectal cancers in the Western hemisphere. Generally characterized by early-onset colorectal carcinoma with a mean age of presentation of 40 to 45 years, it can also manifest with extracolonic adenocarcinomas and cancers of the endometrium, ovaries, stomach, pancreas, small intestine, hepatobiliary tract, upper uroepithelial tract, brain, and skin. HNPCC is autosomal dominant and carries an 80% lifetime risk of cancer development. This review addresses the molecular underpinnings of HNPCC while providing a concise approach to clinical detection, diagnosis, and management of patients who may or may not test positive for an HNPCC-causing mutation. Although applicable to any patient-care setting in which cancer may be observed, this review specifically addresses the role of nurses in detecting, diagnosing, and clinically managing HNPCC.

scholarly journals The role of hereditary nonpolyposis colorectal cancer in the management of familial ovarian cancer

2006 ◽  
Vol 8 (10) ◽  
pp. 653-657 ◽  
Author(s):  
Carolyn Farrell ◽  
Mollie Lyman ◽  
Katherine Freitag ◽  
Cathy Fahey ◽  
M Steven Piver ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Ovarian Cancer ◽  
Hereditary Nonpolyposis Colorectal Cancer ◽  
Hereditary Nonpolyposis ◽  
Familial Ovarian Cancer
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