THE NATURAL HISTORY OF HOMOZYGOUS SICKLE-CELL ANAEMIA IN CENTRAL AFRICA

QJM ◽  
1957 ◽  
2008 ◽  
Vol 142 (1) ◽  
pp. 94-99 ◽  
Author(s):  
Jane S. Hankins ◽  
Gail L. Fortner ◽  
M. Beth McCarville ◽  
Matthew P. Smeltzer ◽  
Winfred C. Wang ◽  
...  

1998 ◽  
Vol 10 (1) ◽  
pp. 49-52 ◽  
Author(s):  
Carolyn Hoppe ◽  
Lori Styles ◽  
Elliott Vichinsky

2020 ◽  
Vol 1 (1) ◽  
pp. 10-19
Author(s):  
O. Agofure ◽  
M. A. Danzaria

The prevalence of sickle cell anaemia has been shown to be on the increase in Nigeria. Therefore, preventive measures such as premarital genotype screening have been proposed as one of the ways of reducing the scourge of the disease. Therefore, this study was designed to assess the knowledge and attitude of women of child bearing age in Kuma Akko Local Government Area of Gombe State towards premarital genotype screening. The study adopted a descriptive cross-sectional design. A total of 296 respondents were sampled through simple random sampling technique and the collected data were analyzed using Statistical Package for the Social Sciences (SPSS) version 20.0. Majority of the respondents 200(71.40%) were between the ages of 15-34 years old and 64(22.90%) of the respondents affirmed that they had a family history of sickle cell disease. In addition, 58.60% of the respondents demonstrated poor knowledge of premarital genotype screening while 57.10% exhibited negative perception towards premarital genotype screening and 63.20% exhibited poor attitude towards premarital genotype screening. There was a significant relationship between respondents with family history of sickle cell anaemia and their knowledge of premarital genotype screening. The study therefore recommends that efforts should be intensified by the governments and health workers in primary, secondary and tertiary level of healthcare deliveries, to raise awareness on the importance of premarital genotype screening in order to reduce the prevalence of Sickle cell anaemia in the locality. Agofure, O. | Department of Public and Community Health, Novena University, Ogume, Delta State, Nigeria.


Thorax ◽  
2019 ◽  
Vol 74 (6) ◽  
pp. 604-606 ◽  
Author(s):  
Michele Arigliani ◽  
Robert Kitenge ◽  
Luigi Castriotta ◽  
Pathy Ndjule ◽  
Vincenzo Barbato ◽  
...  

Lung function in patients with sickle cell anaemia (SCA) living in sub-Saharan Africa is largely unknown. Anthropometry and spirometry were cross-sectionally evaluated in patients with SCA (HbSS) aged 6–18 years and in schoolchildren from the Democratic Republic of the Congo. The Global Lung Initiative 2012 spirometry reference values were used. A total of 112 patients and 377 controls were included. Twenty-six per cent of patients with SCA had spirometry findings suggestive of a restrictive pattern and 41% had a FEV1 z-score <5th percentile. Wasting, increasing age and female sex were independently associated with increased risk of restrictive spirometry pattern in patients with SCA. Longitudinal studies could clarify the prognostic meaning of these findings.


2019 ◽  
Vol 41 (8) ◽  
pp. 606-611
Author(s):  
Vishnu Nagalapuram ◽  
Varsha Kulkarni ◽  
Justin Leach ◽  
Inmaculada Aban ◽  
Krishnaveni Sirigaddi ◽  
...  

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