scholarly journals Contribution of the flexible loop region to the function of staphylococcal enterotoxin B

2010 ◽  
Vol 23 (5) ◽  
pp. 415-421 ◽  
Author(s):  
Saeko Yanaka ◽  
Motonori Kudou ◽  
Yoshikazu Tanaka ◽  
Takumi Sasaki ◽  
Sumiyo Takemoto ◽  
...  
Keyword(s):  
Staphylococcal Enterotoxin ◽  
Staphylococcal Enterotoxin B ◽  
Flexible Loop ◽  
Loop Region ◽  
Enterotoxin B

scholarly journals Structure of the staphylococcal enterotoxin B vaccine candidate S19 showing eliminated superantigen activity

2017 ◽  
Vol 73 (11) ◽  
pp. 595-600
Author(s):  
Woo Hyeon Jeong ◽  
Dong Hyun Song ◽  
Gyeung Haeng Hur ◽  
Seong Tae Jeong
Keyword(s):  
Structural Change ◽  
Mhc Class Ii ◽  
Vaccine Candidate ◽  
Complex Structure ◽  
Cell Receptor ◽  
Staphylococcal Enterotoxin ◽  
Staphylococcal Enterotoxin B ◽  
Loop Region ◽  
T Cell Receptor Beta ◽  
Enterotoxin B

Four mutations (N23A, Y90A, R110A and F177A) were introduced into S19, a vaccine candidate for staphylococcal enterotoxin B (SEB), resulting in a lower binding affinity towards the T-cell receptor beta chain (TCB) and reducing its superantigen activity. The structure of S19 was solved and was superposed on the native or complex structure of SEB. In the superposition model, mutations that were introduced seemed to reduce the number of hydrogen bonds at the SEB–TCB interface. S19 also displayed an unexpected structural change around the flexible-loop region owing to the Y90A mutation. This local structural change provided evidence that the mutated form of S19 could have a lower affinity for major histocompatibility complex (MHC) class II than wild-type SEB.

scholarly journals Rapid and simultaneous detection of ricin, staphylococcal enterotoxin B and saxitoxin by chemiluminescence-based microarray immunoassay

The Analyst ◽  
2014 ◽  
Vol 139 (22) ◽  
pp. 5885-5892 ◽  
Author(s):  
A. Szkola ◽  
E. M. Linares ◽  
S. Worbs ◽  
B. G. Dorner ◽  
R. Dietrich ◽  
...  
Keyword(s):  
Simultaneous Detection ◽  
Staphylococcal Enterotoxin ◽  
Staphylococcal Enterotoxin B ◽  
Microarray Immunoassay ◽  
Enterotoxin B ◽  
Idiotypic Antibody

Simultaneous detection of proteotoxins, ricin and SEB, and small toxin, STX, on a chemiluminescence-based microarray using anti-idiotypic antibody for STX.

scholarly journals Anti-Vβ8 antibodies induce and maintain staphylococcal enterotoxin B-triggered Vβ8+ T cell anergy

1999 ◽  
Vol 29 (2) ◽  
pp. 437-445 ◽  
Author(s):  
Luiz Stark Aroeira ◽  
Concepción G. Mouton ◽  
José L. Toran ◽  
Elizabeth Sally Ward ◽  
Carlos Martínez-A.
Keyword(s):  
T Cell ◽  
Staphylococcal Enterotoxin ◽  
Staphylococcal Enterotoxin B ◽  
T Cell Anergy ◽  
Enterotoxin B ◽  
Cell Anergy

scholarly journals A monoclonal antibody against staphylococcal enterotoxin B superantigen inhibits SARS-CoV-2 entry in vitro

Structure ◽  
2021 ◽  
Author(s):  
Mary Hongying Cheng ◽  
Rebecca A. Porritt ◽  
Magali Noval Rivas ◽  
James M. Krieger ◽  
Asli Beyza Ozdemir ◽  
...  
Keyword(s):  
Monoclonal Antibody ◽  
Staphylococcal Enterotoxin ◽  
Staphylococcal Enterotoxin B ◽  
Enterotoxin B
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