scholarly journals Severe intestinal involvement in Wegener's granulomatosis: report of two cases and review of the literature

Rheumatology ◽  
1998 ◽  
Vol 37 (4) ◽  
pp. 387-390 ◽  
Author(s):  
B Storesund
2000 ◽  
Vol 14 (5) ◽  
pp. 449-451 ◽  
Author(s):  
Glen A Fallows ◽  
Sean F Hamilton ◽  
Douglas S Taylor ◽  
S Bharati Reddy

Wegener’s granulomatosis is characterized by a granulomatous arteritis involving the upper and lower respiratory tracts, progressive glomerulonephritis and systemic symptoms attributable to small vessel vasculitis. Although multisystemic manifestations are frequent, involvement of the gastrointestinal tract is uncommon. Cases have been reported of intestinal perforation, ulceration and hemorrhage. A patient whose initial presentation of Wegener’s granulomatosis was odynophagia secondary to esophageal vasculitis is described. Endoscopy revealed multiple punched out ulcerations in the esophagus, which resolved with standard therapy for systemic Wegener’s granulomatosis. There are only two previous reports of symptomatic esophageal vasculitis in patients with Wegener’s granulomatosis. These reports illustrate the need to consider odynophagia as a reflection of disease activity as opposed to complications of immunosuppressive therapy.


1988 ◽  
Vol 55 (2) ◽  
pp. 181-184 ◽  
Author(s):  
M. J. Norris ◽  
K. J. Tomecki ◽  
W. F. Bergfeld ◽  
W. S. Wilke

1994 ◽  
Vol 108 (2) ◽  
pp. 144-146 ◽  
Author(s):  
J. E. Fenton ◽  
T. J. O'Sullivan

AbstractThree cases of Wegener's granulomatosis are described in which the common presenting symptoms were those of aural discomfort and discharge. The otological manifestations of this disease process are discussed and a review of the literature is presented.


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