The otological manifestations of Wegener's granulomatosis

1994 ◽  
Vol 108 (2) ◽  
pp. 144-146 ◽  
Author(s):  
J. E. Fenton ◽  
T. J. O'Sullivan
Keyword(s):  
Wegener’S Granulomatosis ◽  
Disease Process ◽  
Wegener's Granulomatosis ◽  
Review Of The Literature ◽  
Presenting Symptoms ◽  
The Common

AbstractThree cases of Wegener's granulomatosis are described in which the common presenting symptoms were those of aural discomfort and discharge. The otological manifestations of this disease process are discussed and a review of the literature is presented.

scholarly journals Esophageal Involvement in Wegener’s Granulomatosis: A Case Report and Review of the Literature

2000 ◽  
Vol 14 (5) ◽  
pp. 449-451 ◽  
Author(s):  
Glen A Fallows ◽  
Sean F Hamilton ◽  
Douglas S Taylor ◽  
S Bharati Reddy
Keyword(s):  
Case Report ◽  
Gastrointestinal Tract ◽  
Disease Activity ◽  
Intestinal Perforation ◽  
Standard Therapy ◽  
Wegener’S Granulomatosis ◽  
Wegener's Granulomatosis ◽  
Small Vessel Vasculitis ◽  
Review Of The Literature ◽  
Systemic Symptoms

Wegener’s granulomatosis is characterized by a granulomatous arteritis involving the upper and lower respiratory tracts, progressive glomerulonephritis and systemic symptoms attributable to small vessel vasculitis. Although multisystemic manifestations are frequent, involvement of the gastrointestinal tract is uncommon. Cases have been reported of intestinal perforation, ulceration and hemorrhage. A patient whose initial presentation of Wegener’s granulomatosis was odynophagia secondary to esophageal vasculitis is described. Endoscopy revealed multiple punched out ulcerations in the esophagus, which resolved with standard therapy for systemic Wegener’s granulomatosis. There are only two previous reports of symptomatic esophageal vasculitis in patients with Wegener’s granulomatosis. These reports illustrate the need to consider odynophagia as a reflection of disease activity as opposed to complications of immunosuppressive therapy.

Computed Tomography Findings in Sinonasal Wegener's Granulomatosis

2009 ◽  
Vol 23 (5) ◽  
pp. 497-501 ◽  
Author(s):  
David Grindler ◽  
Steven Cannady ◽  
Pete S. Batra
Keyword(s):  
Computed Tomography ◽  
Wegener’S Granulomatosis ◽  
Tertiary Care ◽  
Disease Process ◽  
Wegener's Granulomatosis ◽  
Sinus Surgery ◽  
Female Ratio ◽  
Bony Destruction ◽  
The Impact ◽  
Bony Erosion

Background Wegener's granulomatosis (WG), an autoimmune disease, is intimately associated with the sinonasal tract, with involvement reported in 85% of patients during the course of the disease process. The objective of this study was (1) to describe Lund-Mackay (L-M) scores, (2) to delineate patterns of neo-osteogenesis and bony erosion, and (3) to analyze the impact of surgery on the computed tomography (CT) findings of WG patients. Methods A retrospective review was performed on 74 patients with WG presenting to a tertiary care referral center. CT analysis was performed and graded by two independent reviewers. Results The mean age was 53 years with a male/female ratio of 0.6:1. The average L-M score was 10.0. Neo-osteogenesis was evident in 78% of the patients with overall average neo-osteogenesis score of 4.2 (range, 0–16). Bony erosion was noted on imaging in 62% of patients with overall average score for bony erosion of 2.0 (range, 0–8). Patients having undergone previous sinus surgery compared with no previous surgery had statistically significant elevation of overall L-M, bony erosion, and neo-osteogenesis scores (p = 0.024, 0.0009, and 0.0015, respectively). Conclusion CT imaging in WG patients shows elevated L-M scores and evidence of bony erosion and neo-osteogenesis. Furthermore, surgical manipulation in WG patients is associated with increased bony abnormalities and greater elevations of L-M scores, possibly because of worsening vasculitis and/or inflammation. The presence of concurrent neo-osteogenesis and bony destruction of the paranasal sinuses should raise clinical suspicion of WG in patients presenting with symptoms of chronic rhinosinusitis.

Cutaneous Wegener's granulomatosis: Report of a case and review of the literature

1988 ◽  
Vol 55 (2) ◽  
pp. 181-184 ◽  
Author(s):  
M. J. Norris ◽  
K. J. Tomecki ◽  
W. F. Bergfeld ◽  
W. S. Wilke
Keyword(s):  
Wegener’S Granulomatosis ◽  
Wegener's Granulomatosis ◽  
Review Of The Literature
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