scholarly journals Disease-modifying anti-rheumatic drug use according to the `sawtooth' treatment strategy improves the functional outcome in rheumatoid arthritis: results of a long-term follow-up study with review of the literature

Rheumatology ◽  
2000 ◽  
Vol 39 (1) ◽  
pp. 34-42 ◽  
Author(s):  
T. Sokka ◽  
T. Möttönen ◽  
P. Hannonen
2019 ◽  
Vol 30 (1) ◽  
pp. 56-63
Author(s):  
Hugo C van der Veen ◽  
Inge HF Reininga ◽  
Wierd P Zijlstra ◽  
Martijn F Boomsma ◽  
Sjoerd K Bulstra ◽  
...  

Background: Metal-on-metal total hip arthroplasty (MoM THA) is associated with the formation of pseudotumours. Studies mainly concern pseudotumour formation in large head MoM THA. We performed a long-term follow-up study, comparing pseudotumour incidence in small head metal-on-metal (SHMoM) THA with conventional metal-on-polyethylene (MoP) THA. Predisposing factors to pseudotumour formation were assessed. Methods: From a previous randomised controlled trial comparing SHMoM (28 mm) cemented THA with conventional MoP cemented THA, patients were screened using a standardised CT protocol for the presence of pseudotumours. Serum cobalt levels and functional outcome were assessed. Results: 56 patients (33 MoP and 23 MoM) were recruited after mean follow-up of 13.4 years (SD 0.5). The incidence of pseudotumours was 1 (5%) in the SHMoM THA cohort and 3 (9%) in the MoP THA cohort. Prosthesis survival was 96% for both SHMoM and MoP THAs. Serum cobalt levels did not exceed acceptable clinical values (<5 µg/L) whereas no differences in cobalt levels were detected at follow-up between both groups. Oxford and Harris Hip Scores were good and did not differ between SHMoM and MoP THA. Conclusions: This long-term follow-up study shows a low incidence of pseudotumour formation and good functional outcome in cemented head-taper matched SHMoM and MoP THA.


2016 ◽  
Vol 2016 ◽  
pp. 1-8 ◽  
Author(s):  
Bengt Wahlin ◽  
Thomas Meedt ◽  
Fredrik Jonsson ◽  
Michael Y. Henein ◽  
Solveig Wållberg-Jonsson

Objective. A long-term follow-up of patients with rheumatoid arthritis (RA) to evaluate factors related to coronary artery calcification (CAC).Methods. All 22 eligible patients (4 males/18 females, mean age 65 years, and RA-duration 30–36 years) from the original (baseline;n=39) study of atherosclerosis were included. Inflammation, cardiovascular risk factors, and biomarkers were measured at baseline. At follow-up 13 years later, CAC was assessed by computed tomography (CT) and the grade of inflammation was measured. Multivariate analysis of differences between patients with low (0–10) and high CAC (>10) was done by orthogonal projection to latent structures (OPLS).Results. Ten patients had CAC 0–10 and 12 had >10 (range 18–1700). Patients with high CAC had significantly higher ESR (24.3 versus 9.9 mm/h) and swollen joint count (2 versus 0). The OPLS models discriminated between patients having high or low CAC. With only baseline variables, the sensitivity was 73% and the specificity 82%. The model that also included inflammatory variables from follow-up had a sensitivity of 89% and a specificity of 85%. Exclusion of baseline intima media thickness and plaque from the latter model modestly reduced the accuracy (sensitivity 80% and specificity 83%).Conclusions. CAC is related to inflammation in patients with RA.


2000 ◽  
Vol 13 (6) ◽  
pp. 519-526 ◽  
Author(s):  
Keiju Fujiwara ◽  
Hajime Owaki ◽  
Masahiro Fujimoto ◽  
Kazuo Yonenobu ◽  
Takahiro Ochi

2010 ◽  
Vol 121 (1-2) ◽  
pp. 156-160 ◽  
Author(s):  
C.M. Bonnín ◽  
A. Martínez-Arán ◽  
C. Torrent ◽  
I. Pacchiarotti ◽  
A.R. Rosa ◽  
...  

Foot & Ankle ◽  
1988 ◽  
Vol 8 (4) ◽  
pp. 173-179 ◽  
Author(s):  
Anthony S. Unger ◽  
Allan E. Inglis ◽  
Christopher S. Mow ◽  
Harry E. Figgie

Patients with rheumatoid arthritis who had undergone total ankle arthroplasty and had a minimum of 2 yr follow-up were studied. Of the original 21 patients 17 were available for review. Twenty-three ankle replacements with an average follow-up of 5.6 yr were studied. On follow-up 2 ankles were rated excellent, 13 were rated good, 4 were rated fair, and 4 were rated poor. Thus, 83% were satisfactory on follow-up. Radiographic analysis revealed migration and settling of the talar component in 14 of 15 cases. Bone cement radiolucencies were found in 14 of 15 cases. Bone cement radiolucencies were found in 14 of 15 tibial components with tilting in 12 of these components. The postoperative position of the implant did not correlate with the development of radiolucencies or migration of the implant.


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