Validity of the Saint George's Respiratory Questionnaire in the evaluation of the health-related quality of life in patients with interstitial lung disease secondary to systemic sclerosis

IntroductionIdiopathic pulmonary fibrosis (IPF) and systemic sclerosis-associated interstitial lung disease (SSc-ILD) are fibrotic ILDs with divergent disease populations. Little is known about health-related quality of life (HRQL) in SSc-ILD relative to IPF.MethodsWe used the Kings Brief Interstitial Lung Disease Questionnaire (K-BILD) to compare HRQL in a cross-sectional study of 57 patients with IPF and 29 patients with SSc-ILD. Analysis of covariance was used to adjust for age, gender and lung function.ResultsThe unadjusted mean K-BILD score was 63.1 (95% CI 57.1 to 69.1) among patients with SSc-ILD, as compared with 54.7 (51.8–57.5) among those with IPF (p=0.005). However, this difference in HRQL was attenuated after adjustment for age, gender and lung function. In a multivariable model, only forced vital capacity was associated with K-BILD scores. K-BILD scores were correlated with both forced vital capacity and with other relevant HRQL measures, regardless of ILD diagnosis.DiscussionPatients with SSc-ILD may have better ILD-specific quality of life than patients with IPF, but this difference appears to be driven primarily by better lung function. These results underscore the impact of lung function on HRQL in fibrotic ILD and the utility of K-BILD to assess HRQL in SSc-ILD.

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Determinants of Health-Related Quality of Life Decline in Interstitial Lung Disease

10.21203/rs.3.rs-21633/v1 ◽

2020 ◽

Author(s):

Phillen Nozibuyiso Maqhuzu ◽

Boglárka Lilla Szentes ◽

Michael Kreuter ◽

Thomas Bahmer ◽

Nicolas Kahn ◽

...

Keyword(s):

Quality Of Life ◽

Interstitial Lung Disease ◽

Lung Disease ◽

Psychological Impact ◽

Sociodemographic Factors ◽

Health Related Quality ◽

Lower Baseline ◽

Related Quality ◽

Health Related

Abstract Background: Health-related quality of life (HRQL) in interstitial lung disease (ILD) patients is impaired. We aimed to identify baseline predictors for HRQL decline within a 12-month observation period. Methods: We analyzed 194 ILD patients from two German ILD-centers in the observational HILDA study. We employed the disease-specific King’s Brief Interstitial Lung Disease questionnaire (K-BILD) with the subdomains ‘psychological impact’, ‘chest symptoms’ and ‘breathlessness and activities’, and the generic EQ-5D Visual Analog Scale (VAS). We evaluated how many patients experienced a clinically meaningful decline in HRQL. Subsequently, we investigated medical and sociodemographic factors as potential predictors of HRQL deterioration. Results: Within the study population (34.0% male, Ø age 61.7) mean HRQL scores hardly changed between baseline and follow up (K-BILD: 52.8 vs. 52.5 | VAS: 60.0 vs. 57.3). On the intra-individual level, 30.4% (n = 59) experienced a clinically relevant deterioration in K-BILD total score and 35.4% (n = 68) in VAS. Lower baseline forced vital capacity % predicted determined HRQL decline in K-BILD total score (ß– coefficient -0.02, p = 0.007), VAS (ß–coefficient -0.03, p < 0.0001), and in the subdomain ‘psychological impact’ (ß– coefficient -0.02, p = 0.014). Lower baseline diffusing capacity of carbon monoxide % predicted determined deterioration in ‘breathlessness and activities’ (ß– coefficient -0.04, p = 0.003) and ‘chest symptoms’ (ß– coefficient -0.04, p = 0.002). Additionally, increasing age predicted decline in ‘psychological impact’ (ß–coefficient 0.06, p < 0.007). Conclusion: A third of ILD patients experience a clinically relevant HRQL deterioration within 12 months, which is mainly predicted by lung function baseline value.

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PRS62 PREDICTORS OF HEALTH-RELATED QUALITY OF LIFE DECLINE IN INTERSTITIAL LUNG DISEASE USING THE K-BILD QUESTIONNAIRE

Value in Health ◽

10.1016/j.jval.2020.04.1381 ◽

2020 ◽

Vol 23 ◽

pp. S360

Author(s):

P.N. Maqhuzu ◽

B. Szentes ◽

M. Kreuter ◽

T. Bahmer ◽

N.C. Kahn ◽

...

Keyword(s):

Quality Of Life ◽

Interstitial Lung Disease ◽

Lung Disease ◽

Health Related Quality ◽

Related Quality ◽

Health Related

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Determinants of health-related quality of life decline in interstitial lung disease

Health and Quality of Life Outcomes ◽

10.1186/s12955-020-01570-2 ◽

2020 ◽

Vol 18 (1) ◽

Author(s):

Phillen Nozibuyiso Maqhuzu ◽

Boglarka L. Szentes ◽

Michael Kreuter ◽

Thomas Bahmer ◽

Nicolas Kahn ◽

...

Keyword(s):

Quality Of Life ◽

Interstitial Lung Disease ◽

Lung Function ◽

Lung Disease ◽

Psychological Impact ◽

Health Related Quality ◽

Lower Baseline ◽

Related Quality ◽

Health Related

Abstract Background Health-related quality of life (HRQL) in interstitial lung disease (ILD) patients is impaired. We aimed to identify baseline predictors for HRQL decline within a 12-month observation period. Methods We analyzed 194 ILD patients from two German ILD-centers in the observational HILDA study. We employed the disease-specific King’s Brief Interstitial Lung Disease questionnaire (K-BILD) with the subdomains ‘psychological impact’, ‘chest symptoms’ and ‘breathlessness and activities’, and the generic EQ-5D Visual Analog Scale (VAS). We evaluated how many patients experienced a clinically meaningful decline in HRQL. Subsequently, we investigated medical and sociodemographic factors as potential predictors of HRQL deterioration. Results Within the study population (34.0% male, Ø age 61.7) mean HRQL scores hardly changed between baseline and follow up (K-BILD: 52.8 vs. 52.5 | VAS: 60.0 vs. 57.3). On the intra-individual level, 30.4% (n = 59) experienced a clinically relevant deterioration in K-BILD total score and 35.4% (n = 68) in VAS. Lower baseline forced vital capacity (FVC) % predicted determined HRQL decline in K-BILD total score (ß-coefficient: − 0.02, p = 0.007), VAS (ß-coefficient: − 0.03, p < 0.0001), and in the subdomain ‘psychological impact’ (ß-coefficient: − 0.02, p = 0.014). Lower baseline diffusing capacity of carbon monoxide (DLCO) % predicted determined deterioration in ‘breathlessness and activities’ (ß-coefficient: − 0.04, p = 0.003) and ‘chest symptoms’ (ß-coefficient: − 0.04, p = 0.002). Additionally, increasing age predicted decline in ‘psychological impact’ (ß-coefficient: 0.06, p < 0.007). Conclusion Around a third of ILD patients experienced a clinically relevant HRQL deterioration in a 12-month period, which was associated with baseline lung function values in all K-BILD domains. As lung function values are time-dependent variables with possible improvements, in contrast to age and ILD subtype, it, thus, seems important to improve lung function and prevent its decline in order to maintain HRQL on the possibly highest level.

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Relationship Between Lung Function Impairment and Health-Related Quality of Life in COPD and Interstitial Lung Disease

CHEST Journal ◽

10.1378/chest.11-1332 ◽

2012 ◽

Vol 142 (3) ◽

pp. 704-711 ◽

Cited By ~ 18

Author(s):

Cristine E. Berry ◽

M. Bradley Drummond ◽

MeiLan K. Han ◽

Daner Li ◽

Cathy Fuller ◽

...

Keyword(s):

Quality Of Life ◽

Interstitial Lung Disease ◽

Lung Function ◽

Lung Disease ◽

Health Related Quality ◽

Function Impairment ◽

Related Quality ◽

Health Related ◽

Lung Function Impairment

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Determinants of health-related quality of life decline in interstitial lung disease

10.21203/rs.3.rs-21633/v2 ◽

2020 ◽

Author(s):

Phillen Nozibuyiso Maqhuzu ◽

Boglárka Lilla Szentes ◽

Michael Kreuter ◽

Thomas Bahmer ◽

Nicolas Kahn ◽

...

Keyword(s):

Quality Of Life ◽

Interstitial Lung Disease ◽

Lung Function ◽

Lung Disease ◽

Psychological Impact ◽

Health Related Quality ◽

Lower Baseline ◽

Related Quality ◽

Health Related

Abstract Background: Health-related quality of life (HRQL) in interstitial lung disease (ILD) patients is impaired. We aimed to identify baseline predictors for HRQL decline within a 12-month observation period. Methods: We analyzed 194 ILD patients from two German ILD-centers in the observational HILDA study. We employed the disease-specific King’s Brief Interstitial Lung Disease questionnaire (K-BILD) with the subdomains ‘psychological impact’, ‘chest symptoms’ and ‘breathlessness and activities’, and the generic EQ-5D Visual Analog Scale (VAS). We evaluated how many patients experienced a clinically meaningful decline in HRQL. Subsequently, we investigated medical and sociodemographic factors as potential predictors of HRQL deterioration. Results: Within the study population (34.0% male, Ø age 61.7) mean HRQL scores hardly changed between baseline and follow up (K-BILD: 52.8 vs. 52.5 | VAS: 60.0 vs. 57.3). On the intra-individual level, 30.4% (n = 59) experienced a clinically relevant deterioration in K-BILD total score and 35.4% (n = 68) in VAS. Lower baseline forced vital capacity % predicted determined HRQL decline in K-BILD total score (ß– coefficient -0.02, p = 0.007), VAS (ß–coefficient -0.03, p < 0.0001), and in the subdomain ‘psychological impact’ (ß– coefficient -0.02, p = 0.014). Lower baseline diffusing capacity of carbon monoxide % predicted determined deterioration in ‘breathlessness and activities’ (ß– coefficient -0.04, p = 0.003) and ‘chest symptoms’ (ß– coefficient -0.04, p = 0.002). Additionally, increasing age predicted decline in ‘psychological impact’ (ß–coefficient 0.06, p < 0.007). Conclusion: Around a third of ILD patients experienced a clinically relevant HRQL deterioration in a 12-month period, which is consistently associated with baseline lung function values. As lung function values are time-dependent variables with possible improvements, it, thus, seems important to diagnose ILD early in order to maintain HRQL on the possibly highest level.

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