scholarly journals Expression of Metallothionein Isoform 3 (MT-3) Determines the Choice between Apoptotic or Necrotic Cell Death in Cd+2-Exposed Human Proximal Tubule Cells

2004 ◽  
Vol 80 (2) ◽  
pp. 358-366 ◽  
Author(s):  
S. Somji
Keyword(s):  
Cell Death ◽  
Proximal Tubule ◽  
Necrotic Cell Death ◽  
Necrotic Cell ◽  
Proximal Tubule Cells ◽  
Tubule Cells ◽  
Human Proximal Tubule ◽  
Metallothionein Isoform 3

scholarly journals Crystals cause acute necrotic cell death in renal proximal tubule cells, but not in collecting tubule cells

2005 ◽  
Vol 68 (4) ◽  
pp. 1543-1553 ◽  
Author(s):  
Marieke S.J. Schepers ◽  
Eddy S. Van Ballegooijen ◽  
Chris H. Bangma ◽  
Carl F. Verkoelen
Keyword(s):  
Cell Death ◽  
Proximal Tubule ◽  
Renal Proximal Tubule ◽  
Necrotic Cell Death ◽  
Necrotic Cell ◽  
Proximal Tubule Cells ◽  
Collecting Tubule ◽  
Tubule Cells ◽  
Renal Proximal Tubule Cells

Anti-inflammatory and antinecrotic effects of the volatile anesthetic sevoflurane in kidney proximal tubule cells

2006 ◽  
Vol 291 (1) ◽  
pp. F67-F78 ◽  
Author(s):  
H. Thomas Lee ◽  
Mihwa Kim ◽  
Michael Jan ◽  
Charles W. Emala
Keyword(s):  
Cell Death ◽  
Proximal Tubule ◽  
Volatile Anesthetics ◽  
Necrotic Cell Death ◽  
Necrotic Cell ◽  
Proximal Tubule Cells ◽  
Kidney Proximal Tubule ◽  
Tnf Α ◽  
Tubule Cells ◽  
Anti Inflammatory

Renal ischemia-reperfusion (IR) injury is a major clinical problem without effective therapy. We recently reported that volatile anesthetics protect against renal IR injury, in part, via their anti-inflammatory properties. In this study, we demonstrate the anti-inflammatory and antinecrotic effects of sevoflurane in cultured kidney proximal tubule cells and probed the mechanisms of sevoflurane-induced renal cellular protection. To mimic inflammation, human kidney proximal tubule (HK-2) cells were treated with tumor necrosis factor-α (TNF-α; 25 ng/ml) in the presence or absence of sevoflurane. In addition, we studied the effects of sevoflurane pretreatment on hydrogen peroxide (H2O2)-induced necrotic cell death in HK-2 or porcine proximal tubule (LLC-PK1) cells. We demonstrate that sevoflurane suppressed proinflammatory effects of TNF-α evidenced by attenuated upregulation of proinflammatory cytokine mRNA (TNF-α, MCP-1) and ICAM-1 protein and reduced nuclear translocation of the proinflammatory transcription factors NF-κB and AP-1. Sevoflurane reduced necrotic cell death induced with H2O2 in HK-2 cells as well as in LLC-PK1 cells. Sevoflurane treatment resulted in phosphorylation of prosurvival kinases, ERK and Akt, and increased de novo HSP-70 protein synthesis without affecting the synthesis of HSP-27 or HSP-32. We conclude that sevoflurane has direct anti-inflammatory and antinecrotic effects in vitro in a renal cell type particularly sensitive to injury following IR injury. These mechanisms may, in part, account for volatile anesthetics' protective effects against renal IR injury.

Mesna or cysteine prevents chloroacetaldehyde-induced cell death of human proximal tubule cells

2007 ◽  
Vol 22 (6) ◽  
pp. 798-803 ◽  
Author(s):  
Gerald Schwerdt ◽  
Antje Kirchhoff ◽  
Ruth Freudinger ◽  
Brigitte Wollny ◽  
Andreas Benesic ◽  
...  
Keyword(s):  
Cell Death ◽  
Proximal Tubule ◽  
Proximal Tubule Cells ◽  
Tubule Cells ◽  
Human Proximal Tubule

Heterogeneity in the amount of ionic cadmium necessary to elicit cell death in independent cultures of human proximal tubule cells

1994 ◽  
Vol 70 (2) ◽  
pp. 185-191 ◽  
Author(s):  
Mary Ann Sens ◽  
Debra J. Hazen-Martin ◽  
John E. Bylander ◽  
Donald A. Sens
Keyword(s):  
Cell Death ◽  
Proximal Tubule ◽  
Proximal Tubule Cells ◽  
Tubule Cells ◽  
Human Proximal Tubule

Transient induction of metallothionein isoform 3 (MT-3), c-fos, c-jun and c-myc in human proximal tubule cells exposed to cadmium

2002 ◽  
Vol 126 (1) ◽  
pp. 69-80 ◽  
Author(s):  
Scott H Garrett ◽  
Veronica Phillips ◽  
Seema Somji ◽  
Mary Ann Sens ◽  
Rana Dutta ◽  
...  
Keyword(s):  
Proximal Tubule ◽  
Proximal Tubule Cells ◽  
Tubule Cells ◽  
Human Proximal Tubule ◽  
Metallothionein Isoform 3

scholarly journals Cadherin Expression, Vectorial Active Transport, and Metallothionein Isoform 3 Mediated EMT/MET Responses in Cultured Primary and Immortalized Human Proximal Tubule Cells

PLoS ONE ◽  
2015 ◽  
Vol 10 (3) ◽  
pp. e0120132 ◽  
Author(s):  
Andrea Slusser ◽  
Chandra S. Bathula ◽  
Donald A. Sens ◽  
Seema Somji ◽  
Mary Ann Sens ◽  
...  
Keyword(s):  
Proximal Tubule ◽  
Active Transport ◽  
Proximal Tubule Cells ◽  
Tubule Cells ◽  
Human Proximal Tubule ◽  
Metallothionein Isoform 3

scholarly journals Electrophysiology and ultrastructure of cultured human proximal tubule cells

1988 ◽  
Vol 33 (2) ◽  
pp. 508-516 ◽  
Author(s):  
John G. Blackburn ◽  
Debra J. Hazen-Martin ◽  
Carol J. Detrisac ◽  
Donald A. Sens
Keyword(s):  
Proximal Tubule ◽  
Proximal Tubule Cells ◽  
Tubule Cells ◽  
Human Proximal Tubule

scholarly journals Uremic Toxins Induce ET-1 Release by Human Proximal Tubule Cells, which Regulates Organic Cation Uptake Time-Dependently

Cells ◽  
2015 ◽  
Vol 4 (3) ◽  
pp. 234-252 ◽  
Author(s):  
Carolien Schophuizen ◽  
Joost Hoenderop ◽  
Rosalinde Masereeuw ◽  
Lambert Heuvel
Keyword(s):  
Proximal Tubule ◽  
Organic Cation ◽  
Uremic Toxins ◽  
Proximal Tubule Cells ◽  
Cation Uptake ◽  
Tubule Cells ◽  
Human Proximal Tubule
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