Quantitative Risk Analysis for N-Methyl Pyrrolidone Using Physiologically Based Pharmacokinetic and Benchmark Dose Modeling

Toxicological Sciences ◽

10.1093/toxsci/kfp264 ◽

2009 ◽

Vol 113 (2) ◽

pp. 468-482 ◽

Author(s):

Torka S. Poet ◽

Chris R. Kirman ◽

Michael Bader ◽

Christoph van Thriel ◽

Michael L. Gargas ◽

...

Keyword(s):

Risk Analysis ◽

Benchmark Dose ◽

Quantitative Risk Analysis ◽

Physiologically Based Pharmacokinetic ◽

Physiologically Based ◽

Methyl Pyrrolidone

Download Full-text

Using physiologically based pharmacokinetic modeling and benchmark dose methods to derive an occupational exposure limit for N-methylpyrrolidone

Regulatory Toxicology and Pharmacology ◽

10.1016/j.yrtph.2015.12.020 ◽

2016 ◽

Vol 76 ◽

pp. 102-112 ◽

Author(s):

T.S. Poet ◽

P.M. Schlosser ◽

C.E. Rodriguez ◽

R.J. Parod ◽

D.E. Rodwell ◽

...

Keyword(s):

Occupational Exposure ◽

Pharmacokinetic Modeling ◽

Benchmark Dose ◽

Occupational Exposure Limit ◽

Physiologically Based Pharmacokinetic Modeling ◽

Physiologically Based Pharmacokinetic ◽

Exposure Limit ◽

Physiologically Based

Download Full-text

Impact of Physiologically Based Pharmacokinetic Modeling on Benchmark Dose Calculations for TCDD-Induced Biochemical Responses

Regulatory Toxicology and Pharmacology ◽

10.1006/rtph.2002.1590 ◽

2002 ◽

Vol 36 (3) ◽

pp. 287-296 ◽

Author(s):

Amy H. Kim ◽

Michael C. Kohn ◽

Christopher J. Portier ◽

Nigel J. Walker

Keyword(s):

Pharmacokinetic Modeling ◽

Benchmark Dose ◽

Dose Calculations ◽

Physiologically Based Pharmacokinetic Modeling ◽

Biochemical Responses ◽

Physiologically Based Pharmacokinetic ◽

Physiologically Based

Download Full-text

Estimation of Lead Elimination Rates for Liver and Kidney Using a Physiologically- Based Pharmacokinetic Model for Improved Human Risk Analysis

Human and Ecological Risk Assessment An International Journal ◽

10.1080/10807039.2012.672899 ◽

2012 ◽

Vol 18 (3) ◽

pp. 627-648 ◽

Author(s):

Mukesh Sharma ◽

Sangam Uma Reddy

Keyword(s):

Risk Analysis ◽

Pharmacokinetic Model ◽

Physiologically Based Pharmacokinetic Model ◽

Physiologically Based Pharmacokinetic ◽

Physiologically Based ◽

Liver And Kidney

Download Full-text

16 Using physiologically based pharmacokinetic (PBPK) modelling and SCHOLZ databank’s MDDI calculator (SDB-MDDI) to predict potential drug-drug interactions (DDI) of psychopharmaceuticals

10.1055/s-0040-1710124 ◽

2020 ◽

Author(s):

UR Lücht ◽

AK Geiben ◽

S Brune ◽

WU Scholz ◽

G Hempel

Keyword(s):

Drug Interactions ◽

Potential Drug ◽

Pbpk Modelling ◽

Physiologically Based Pharmacokinetic ◽

Physiologically Based

Download Full-text

49. A Physiologically Based Pharmacokinetic/Pharmacodynamic (PBPK/PD) Model for Chlorpyrifos Utilizing Neonatal Rats as Surrogates for Children

10.3320/1.2766399 ◽

2002 ◽

Author(s):

C. Timchalk ◽

A. Kousba ◽

T. Poet

Keyword(s):

Neonatal Rats ◽

Physiologically Based Pharmacokinetic ◽

Physiologically Based

Download Full-text

Physiologically-based pharmacokinetic modeling of different size polyethylene glycol-coated gold nanoparticles in mice

10.1615/ihtc16.nmt.023362 ◽

2018 ◽

Author(s):

Linjing Deng ◽

Jinping Zhao ◽

Yufeng Miao ◽

Xu Hu ◽

Qihong Deng

Keyword(s):

Gold Nanoparticles ◽

Polyethylene Glycol ◽

Pharmacokinetic Modeling ◽

Physiologically Based Pharmacokinetic Modeling ◽

Physiologically Based Pharmacokinetic ◽

Physiologically Based

Download Full-text

Physiologically-Based Pharmacokinetic Modeling to Predict Changes in Drug Exposure during Pregnancy Using the Simcyp Simulator

10.26226/morressier.57d6b2b7d462b8028d88e945 ◽

2016 ◽

Author(s):

Suvarchala Kiranmai Avvari

Keyword(s):

Drug Exposure ◽

Pharmacokinetic Modeling ◽

Physiologically Based Pharmacokinetic Modeling ◽

Physiologically Based Pharmacokinetic ◽

Physiologically Based ◽

Exposure During Pregnancy

Download Full-text

Using Physiologically Based Pharmacokinetic (PBPK) Modeling as a Supportive Tool for Risk Assessment on the Critical Quality Attribute of a Generic Drug Product

10.26226/morressier.57d6b2bcd462b8028d88e03d ◽

2016 ◽

Author(s):

Fang Wu

Keyword(s):

Risk Assessment ◽

Generic Drug ◽

Drug Product ◽

Pbpk Modeling ◽

Quality Attribute ◽

Critical Quality Attribute ◽

Physiologically Based Pharmacokinetic ◽

Generic Drug Product ◽

Physiologically Based

Download Full-text

Physiologically based pharmacokinetic model development for trazodone: application to paediatric dose projection

10.26226/morressier.5971be87d462b80290b534f2 ◽

2017 ◽

Author(s):

F. Calisti

Keyword(s):

Pharmacokinetic Model ◽

Model Development ◽

Physiologically Based Pharmacokinetic Model ◽

Physiologically Based Pharmacokinetic ◽

Physiologically Based ◽

Paediatric Dose

Download Full-text

Physiologically‐Based Pharmacokinetic Modeling of Atorvastatin Incorporating Delayed Gastric Emptying and Acid‐to‐Lactone Conversion

CPT Pharmacometrics & Systems Pharmacology ◽

10.1002/psp4.12447 ◽

2019 ◽

Vol 8 (9) ◽

pp. 664-675 ◽

Author(s):

Bridget L. Morse ◽

Jeffrey J. Alberts ◽

Maria M. Posada ◽

Jessica Rehmel ◽

Anil Kolur ◽

...

Keyword(s):

Gastric Emptying ◽

Delayed Gastric Emptying ◽

Pharmacokinetic Modeling ◽

Physiologically Based Pharmacokinetic Modeling ◽

Physiologically Based Pharmacokinetic ◽

Physiologically Based

Download Full-text