16 Using physiologically based pharmacokinetic (PBPK) modelling and SCHOLZ databank’s MDDI calculator (SDB-MDDI) to predict potential drug-drug interactions (DDI) of psychopharmaceuticals

Mapping Intimacies ◽

10.1055/s-0040-1710124 ◽

2020 ◽

Author(s):

UR Lücht ◽

AK Geiben ◽

S Brune ◽

WU Scholz ◽

G Hempel

Keyword(s):

Drug Interactions ◽

Potential Drug ◽

Pbpk Modelling ◽

Physiologically Based Pharmacokinetic ◽

Physiologically Based

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Implementation of a Physiologically Based Pharmacokinetic Modeling Approach to Guide Optimal Dosing Regimens for Imatinib and Potential Drug Interactions in Paediatrics

Frontiers in Pharmacology ◽

10.3389/fphar.2019.01672 ◽

2020 ◽

Vol 10 ◽

Author(s):

Jeffry Adiwidjaja ◽

Alan V. Boddy ◽

Andrew J. McLachlan

Keyword(s):

Drug Interactions ◽

Pharmacokinetic Modeling ◽

Potential Drug ◽

Physiologically Based Pharmacokinetic Modeling ◽

Modeling Approach ◽

Physiologically Based Pharmacokinetic ◽

Optimal Dosing ◽

Physiologically Based ◽

Dosing Regimens

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A Physiologically Based Pharmacokinetic Model to Predict Potential Drug–Drug Interactions and Inform Dosing of Acumapimod, an Oral p38 MAPK Inhibitor

CPT Pharmacometrics & Systems Pharmacology ◽

10.1002/psp4.12565 ◽

2020 ◽

Author(s):

Alex Agyemang ◽

Colm Farrell ◽

William Moore ◽

Jacqueline Parkin

Keyword(s):

Drug Interactions ◽

P38 Mapk ◽

Pharmacokinetic Model ◽

Physiologically Based Pharmacokinetic Model ◽

Potential Drug ◽

Physiologically Based Pharmacokinetic ◽

Physiologically Based ◽

P38 Mapk Inhibitor ◽

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Application of Physiologically Based Pharmacokinetic Modeling to Predict Drug Exposure and Support Dosing Recommendations for Potential Drug‐Drug Interactions or in Special Populations: An Example Using Tofacitinib

The Journal of Clinical Pharmacology ◽

10.1002/jcph.1679 ◽

2020 ◽

Vol 60 (12) ◽

pp. 1617-1628

Author(s):

Susanna Tse ◽

Martin E. Dowty ◽

Sujatha Menon ◽

Pankaj Gupta ◽

Sriram Krishnaswami

Keyword(s):

Drug Interactions ◽

Drug Exposure ◽

Pharmacokinetic Modeling ◽

Special Populations ◽

Potential Drug ◽

Physiologically Based Pharmacokinetic Modeling ◽

Physiologically Based Pharmacokinetic ◽

Physiologically Based

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Assessing Potential Drug-Drug Interactions Between Dabigatran Etexilate and a P-Glycoprotein Inhibitor in Renal Impairment Populations Using Physiologically Based Pharmacokinetic Modeling

CPT Pharmacometrics & Systems Pharmacology ◽

10.1002/psp4.12382 ◽

2019 ◽

Vol 8 (2) ◽

pp. 118-126 ◽

Author(s):

Kosuke Doki ◽

Sibylle Neuhoff ◽

Amin Rostami-Hodjegan ◽

Masato Homma

Keyword(s):

Renal Impairment ◽

Drug Interactions ◽

Dabigatran Etexilate ◽

Pharmacokinetic Modeling ◽

Potential Drug ◽

Physiologically Based Pharmacokinetic Modeling ◽

Physiologically Based Pharmacokinetic ◽

P Glycoprotein ◽

Physiologically Based

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Physiologically based pharmacokinetic modelling to support the clinical management of drug‐drug interactions with bictegravir

Clinical Pharmacology & Therapeutics ◽

10.1002/cpt.2221 ◽

2021 ◽

Author(s):

Felix Stader ◽

Manuel Battegay ◽

Catia Marzolini

Keyword(s):

Drug Interactions ◽

Clinical Management ◽

Pharmacokinetic Modelling ◽

Physiologically Based Pharmacokinetic ◽

Physiologically Based Pharmacokinetic Modelling ◽

Physiologically Based

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A repository of protein abundance data of drug metabolizing enzymes and transporters for applications in physiologically based pharmacokinetic (PBPK) modelling and simulation

Scientific Reports ◽

10.1038/s41598-019-45778-9 ◽

2019 ◽

Vol 9 (1) ◽

Author(s):

Mayur K. Ladumor ◽

Aarzoo Thakur ◽

Sheena Sharma ◽

Aravind Rachapally ◽

Sarang Mishra ◽

...

Keyword(s):

Modelling And Simulation ◽

Drug Metabolizing Enzymes ◽

Protein Abundance ◽

Pbpk Modelling ◽

Metabolizing Enzymes ◽

Abundance Data ◽

Physiologically Based Pharmacokinetic ◽

Physiologically Based

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Physiologically Based Pharmacokinetic Modeling Approach to Predict Drug‐Drug Interactions With Ethionamide Involving Impact of Genetic Polymorphism on FMO3

The Journal of Clinical Pharmacology ◽

10.1002/jcph.1378 ◽

2019 ◽

Vol 59 (6) ◽

pp. 880-889 ◽

Author(s):

Phuong Thi Thu Nguyen ◽

Md Masud Parvez ◽

Min Jung Kim ◽

Sung Eun Yoo ◽

Sangzin Ahn ◽

...

Keyword(s):

Genetic Polymorphism ◽

Drug Interactions ◽

Pharmacokinetic Modeling ◽

Physiologically Based Pharmacokinetic Modeling ◽

Modeling Approach ◽

Physiologically Based Pharmacokinetic ◽

Physiologically Based

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A Physiologically Based Pharmacokinetic Model of Voriconazole Integrating Time-Dependent Inhibition of CYP3A4, Genetic Polymorphisms of CYP2C19 and Predictions of Drug–Drug Interactions

Clinical Pharmacokinetics ◽

10.1007/s40262-019-00856-z ◽

2019 ◽

Vol 59 (6) ◽

pp. 781-808 ◽

Author(s):

Xia Li ◽

Sebastian Frechen ◽

Daniel Moj ◽

Thorsten Lehr ◽

Max Taubert ◽

...

Keyword(s):

Drug Interactions ◽

Genetic Polymorphisms ◽

Pharmacokinetic Model ◽

Time Dependent ◽

Physiologically Based Pharmacokinetic Model ◽

Physiologically Based Pharmacokinetic ◽

Physiologically Based ◽

Dependent Inhibition ◽

Time Dependent Inhibition

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Physiologically Based Pharmacokinetic Model Predictions of Panobinostat (LBH589) as a Victim and Perpetrator of Drug-Drug Interactions

Drug Metabolism and Disposition ◽

10.1124/dmd.117.076851 ◽

2017 ◽

Vol 45 (12) ◽

pp. 1304-1316 ◽

Author(s):

Heidi J. Einolf ◽

Wen Lin ◽

Christina S. Won ◽

Lai Wang ◽

Helen Gu ◽

...

Keyword(s):

Drug Interactions ◽

Pharmacokinetic Model ◽

Physiologically Based Pharmacokinetic Model ◽

Physiologically Based Pharmacokinetic ◽

Model Predictions ◽

Physiologically Based

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Physiologically based pharmacokinetic modeling to predict complex drug-drug interactions: a case study of AZD2327 and its metabolite, competitive and time-dependent CYP3A inhibitors

Biopharmaceutics & Drug Disposition ◽

10.1002/bdd.1962 ◽

2015 ◽

Vol 36 (8) ◽

pp. 507-519 ◽

Author(s):

Jian Guo ◽

Diansong Zhou ◽

Yan Li ◽

Bui H. Khanh

Keyword(s):

Drug Interactions ◽

Pharmacokinetic Modeling ◽

Time Dependent ◽

Physiologically Based Pharmacokinetic Modeling ◽

Physiologically Based Pharmacokinetic ◽

Physiologically Based ◽

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